Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Martha Konieczkowski"'
Autor:
Sethu M. Madhavan, Martha Konieczkowski, Leslie A. Bruggeman, Megan DeWalt, Jane K. Nguyen, John F. O’Toole, John R. Sedor
Publikováno v:
American Journal of Physiology-Renal Physiology. 323:F272-F287
Wilms' tumor interacting protein (Wtip) has been implicated in cell junction assembly and cell differentiation and interacts with proteins in the podocyte slit diaphragm, where it regulates podocyte phenotype. To define Wtip expression and function i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c9e4dff3915486f5f5358be909a54a
https://doi.org/10.1152/ajprenal.00051.2022
https://doi.org/10.1152/ajprenal.00051.2022
Autor:
Martha Konieczkowski, Yaping Gu, Leslie A. Bruggeman, William P. Schilling, John F. O’Toole, Sethu M. Madhavan, John R. Sedor, Diana L. Kunze, Zhenzhen Wu, Liping Luo
Coding variants in the APOL1 gene are associated with kidney diseases in African ancestral populations; yet, the underlying biologic mechanisms remain uncertain. Variant-dependent autophagic and cytotoxic cell death have been proposed as pathogenic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b73a0dc07703e86e5320bc2d6a61195
https://europepmc.org/articles/PMC5827587/
https://europepmc.org/articles/PMC5827587/
Autor:
Santhi Ganesan, Leslie A. Bruggeman, Laura Barisoni, Sethu M. Madhavan, John F. O'Toole, David B. Thomas, Martha Konieczkowski, John R. Sedor, Matthias Buck
APOL1 variants in African populations mediate resistance to trypanosomal infection but increase risk for kidney diseases through unknown mechanisms. APOL1 is expressed in glomerular podocytes and does not vary with underlying kidney disease diagnoses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67122c98285dd08d25a790fe41414f4d
https://europepmc.org/articles/PMC5518555/
https://europepmc.org/articles/PMC5518555/
Autor:
David B. Thomas, Martha Konieczkowski, Zhenzhen Wu, John F. O'Toole, Sethu M. Madhavan, Laura Barisoni, Leslie A. Bruggeman, Liping Luo, John R. Sedor, Paul E. Drawz
APOL1 risk variants are associated with kidney disease in blacks, but the mechanisms of renal injury associated with APOL1 risk variants are unknown. Because APOL1 is unique to humans and some primates, we created transgenic (Tg) mice using the promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f71812f4aa5add5c137a3a92fa193e7
https://europepmc.org/articles/PMC5118487/
https://europepmc.org/articles/PMC5118487/
Autor:
Martha Konieczkowski, Santhi Ganesan, John F. O'Toole, John R. Sedor, Leslie A. Bruggeman, Sethu M. Madhavan
Publikováno v:
Journal of the American Society of Nephrology. 22:2119-2128
In patients of African ancestry, genetic variants in APOL1, which encodes apolipoprotein L1, associate with the nondiabetic kidney diseases, focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy (HIVAN), and hypertensive nephropathy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f4964be498d9dca6979706de35fe16
https://doi.org/10.1681/asn.2011010069
https://doi.org/10.1681/asn.2011010069
Autor:
Martha Konieczkowski, Amy L. Wilson-Delfosse, Xiaofeng Tong, Payal N. Gandhi, Yoshimi Takai, John R. Sedor, Richard M. Gibson, Jun Miyoshi
Publikováno v:
Experimental Cell Research. 301:211-222
Cdc42 is a member of the Rho family of GTPases and plays an important role in the regulation of actin cytoskeletal organization. Activation of Cdc42 and associated signal transduction cascades are dependent upon proper localization of this GTPase. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056cad1e654468d1268b04503f6a7fca
https://doi.org/10.1016/j.yexcr.2004.07.033
https://doi.org/10.1016/j.yexcr.2004.07.033
Autor:
George Jarad, Martha Konieczkowski, Carlos A. Obejero-Paz, Amitava Mukherjee, Sujata Lakhe-Reddy, Jeffrey R. Schelling, Karen L. Wu, Shenaz Khan, John R. Sedor
Publikováno v:
Journal of Biological Chemistry. 279:26280-26286
Apoptosis results in cell shrinkage and intracellular acidification, processes opposed by the ubiquitously expressed NHE1 Na(+)/H(+) exchanger. In addition to mediating Na(+)/H(+) transport, NHE1 interacts with ezrin/radixin/moesin (ERM), which tethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207be46420fc9d425f970020b3d8941c
https://doi.org/10.1074/jbc.m400814200
https://doi.org/10.1074/jbc.m400814200
Autor:
John R. Sedor, Sujata Lakhe-Reddy, R. Tyler Miller, Liming Wang, Arthur M. Brown, Jeffrey R. Schelling, Shenaz Khan, Martha Konieczkowski, Karen L. Wu, George Jarad
Publikováno v:
American Journal of Physiology-Renal Physiology. 284:F829-F839
Renal tubular epithelial cell (RTC) apoptosis causes tubular atrophy, a hallmark of renal disease progression. Apoptosis is generally characterized by reduced cell volume and cytosolic pH, but epithelial cells are relatively resistant to shrinkage du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b95775b0718afe26153851d58e43918
https://doi.org/10.1152/ajprenal.00314.2002
https://doi.org/10.1152/ajprenal.00314.2002
Autor:
Jeffrey R. Schelling, George Jarad, Hui Miao, John R. Sedor, Jay DeVore, Barbara A. Wible, Karen Wu, Martha Konieczkowski, Bingcheng Wang, Stephen L. Nishimura, Shenaz Khan
Publikováno v:
Journal of Biological Chemistry. 277:47826-47833
Cell fate following Fas (CD95) ligand or agonistic anti-Fas antibody stimulation is determined by multiple factors, including Fas expression level, microdomain localization, and modulating cytokines. Highly expressed Fas clusters and activates a cano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5733f0033117f2c2089f684857d700a6
https://doi.org/10.1074/jbc.m204901200
https://doi.org/10.1074/jbc.m204901200
Autor:
S. Kamat, S. Khan, John R. Sedor, Jeffrey R. Schelling, R. Singh, Bingcheng Wang, A. Shirvaikar, Martha Konieczkowski
Publikováno v:
Journal of Clinical Investigation. 103:1561-1570
IL-1–stimulated mesenchymal cells model molecular mechanisms of inflammation. Binding of IL-1 to the type I IL-1 receptor (IL-1R) clusters a multi-subunit signaling complex at focal adhesion complexes. Since Rho family GTPases coordinately organize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2616bce86a959db1df145e7a67ebbd5
https://doi.org/10.1172/jci5754
https://doi.org/10.1172/jci5754