Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Martha K. Pastuszka"'
Publikováno v:
Protein Science. 26:1785-1795
Elastin-Like Polypeptides (ELPs) reversibly phase separate in response to changes in temperature, pressure, concentration, pH, and ionic species. While powerful triggers, biological microenvironments present a multitude of more specific biological cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c36cd84d750c6c894184e80c87ec3ac
https://doi.org/10.1002/pro.3215
https://doi.org/10.1002/pro.3215
Publikováno v:
Pharmaceutics
Volume 11
Issue 5
Pharmaceutics, Vol 11, Iss 5, p 221 (2019)
Volume 11
Issue 5
Pharmaceutics, Vol 11, Iss 5, p 221 (2019)
Contact lenses are widely prescribed for vision correction, and as such they are an attractive platform for drug delivery to the anterior segment of the eye. This manuscript explores a novel strategy to drive the reversible adsorption of peptide-base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48313e8aa94cd3f24e1d572e1b1c4274
https://pubmed.ncbi.nlm.nih.gov/31067782
https://pubmed.ncbi.nlm.nih.gov/31067782
Autor:
J. Andrew MacKay, Martha K. Pastuszka
Publikováno v:
WIREs Nanomedicine and Nanobiotechnology. 8:123-138
Self-assembly enables exquisite control at the smallest scale and generates order amongst macromolecular building blocks that remain too small to be manipulated individually. Environmental cues, such as heating, can trigger the organization of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4d457f9c7d31d4c7935cec4ec55f4f
https://doi.org/10.1002/wnan.1350
https://doi.org/10.1002/wnan.1350
Publikováno v:
Protein science : a publication of the Protein Society. 26(9)
Elastin‐Like Polypeptides (ELPs) reversibly phase separate in response to changes in temperature, pressure, concentration, pH, and ionic species. While powerful triggers, biological microenvironments present a multitude of more specific biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4dfcbb89f26f33ec1e9d2aefe138bce6
https://pubmed.ncbi.nlm.nih.gov/28639381
https://pubmed.ncbi.nlm.nih.gov/28639381
Autor:
Siti M. Janib, Martha K. Pastuszka, J. Andrew MacKay, Lye Lin Lock, Honggang Cui, Xiangdong Wang, Laurie D. DeLeve
Publikováno v:
Journal of Controlled Release. 191:15-23
L4F, an alpha helical peptide inspired by the lipid-binding domain of the ApoA1 protein, has potential applications in the reduction of inflammation involved with cardiovascular disease as well as an antioxidant effect that inhibits liver fibrosis. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9083070e7223fba96ae53e4e19807d3
https://doi.org/10.1016/j.jconrel.2014.07.003
https://doi.org/10.1016/j.jconrel.2014.07.003
Autor:
Steve Swenson, Martha K. Pastuszka, Frank Markland, Peter S. Conti, Zibo Li, Siti M. Janib, Radu O. Minea, Shuanglong Liu, J. Andrew MacKay
Publikováno v:
Advanced Materials Research. 1024:287-291
The goal of our study is to develop genetically engineered polypeptides that self-assemble into nanoparticulates, which can present functional moieties on their exterior and sequester drugs and/or imaging agents within their interior. These particula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38ff44a012734baf93451f215d68a41b
https://doi.org/10.4028/www.scientific.net/amr.1024.287
https://doi.org/10.4028/www.scientific.net/amr.1024.287
Autor:
Honggang Cui, Francis S. Markland, Martha K. Pastuszka, Stephen Swenson, J. Andrew MacKay, Siti M. Janib, Peter S. Conti, Radu O. Minea, Lye Lin Lock, Zibo Li, Joshua A. Gustafson, Shuanglong Liu
Publikováno v:
Biomacromolecules
Recombinant protein therapeutics have increased in number and frequency since the introduction of human insulin, 25 years ago. Presently, proteins and peptides are commonly used in the clinic. However, the incorporation of peptides into clinically ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d336bb227eb87536f71c084b9eb6ac4
http://europepmc.org/articles/PMC4098058
http://europepmc.org/articles/PMC4098058
Publikováno v:
Advanced Materials. 26:449-454
The various highly compartmentalized, membrane-bound organelles are essential for cellular metabolism in eukaryotic cells.[1,2] The specialized composition of proteins and lipids in different organelles enables them to accomplish specialized processe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9c05cd63a59dcf23b87e849f915f53
https://doi.org/10.1002/adma.201303356
https://doi.org/10.1002/adma.201303356
Autor:
R. Park, Peter S. Conti, Ara S. Moses, Yi-An Lin, Siti M. Janib, Manuel M. Orosco, Martha K. Pastuszka, Zibo Li, Honggang Cui, John Andrew MacKay, Pu Shi, Shuanglong Liu
Publikováno v:
Integrative Biology. 5:183-194
Protein polymers are repetitive amino acid sequences that can assemble monodisperse nanoparticles with potential applications as cancer nanomedicines. Of the currently available molecular imaging methods, positron emission tomography (PET) is the mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af9196cfc61feadfbdca6dc61f1836e
https://doi.org/10.1039/c2ib20169k
https://doi.org/10.1039/c2ib20169k
Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains
Publikováno v:
Advanced functional materials. 24(34)
A ubiquitous approach to study protein function is to knock down activity (gene deletions, siRNA, small molecule inhibitors, etc) and study the cellular effects. Using a new methodology, this manuscript describes how to rapidly and specifically switc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dea7f4c8fb134981052b7bc5e2ba18b
https://pubmed.ncbi.nlm.nih.gov/25419208
https://pubmed.ncbi.nlm.nih.gov/25419208