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pro vyhledávání: '"Martha Heine"'
Publikováno v:
The Journal of Experimental Medicine
TWO STRAINS OF RAT HAVE BEEN DEVELOPED BY SELECTIVE BREEDING: one strain (R rats) is resistant to salt hypertension, the other strain (S rats) is highly susceptible. The inheritance of these traits has been explored in the first (F(1)) and second (F(
Publikováno v:
Journal of Experimental Medicine. 129:507-522
The effects of several renal manipulations including uninephrectomy, unilateral renal artery constriction, and a combination of these two (Goldblatt procedure) were studied in two strains of rats with opposite constitutional predispositions to experi
Publikováno v:
The Journal of Experimental Medicine
Parabiosis has been found to modify the expected blood pressure response of rats from two strains with opposite genetic propensities for experimental hypertension. When a member from one strain was united in parabiosis with a member from the other an
Publikováno v:
Journal of Clinical Investigation. 39:420-425
Publikováno v:
Journal of Experimental Medicine. 130:1353-1365
Rats from two strains with opposite constitutional predisposition to hypertension were joined in parabiosis and one partner was nephrectomized. The influence of genetic factors and of diet on the blood pressures of the two classes of parabionts, oper
Autor:
Martha Heine, Lewis K. Dahl
Publikováno v:
Journal of Experimental Medicine. 113:1067-1076
Female rats were fed diets containing either excess sea salt or excess sodium chloride for periods up to 14 months. The hypertension produced by sea salt was more pronounced than that caused by sodium chloride alone, although the average amount of so
Publikováno v:
The Journal of Experimental Medicine
By selective inbreeding, two strains of rats were developed previously that differed markedly in their susceptibility to the development of experimental hypertension from excess salt ingestion (1, 2). The present report indicates that with animals de
Publikováno v:
Experimental Biology and Medicine. 133:1405-1408
SummarySome processed baby foods were lethal to hypertension-prone rats. Among 25 rats from a genetically hypertension-prone strain fed solely on such baby foods, all developed significant hypertension (averaging 180–190 mm Hg in the last 3 months
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 158(3)
In Dahl hypertension-resistant (R) and hypertension-sensitive (S) lines of rats, an ip cadmium injection exacerbated two-kidney Goldblatt hypertension and mortality in S but not in R rats. Renal and hepatic cadmium concentrations of S rats were marke
Autor:
Martha Heine, Lewis K. Dahl
Publikováno v:
Circulation research. 36(6)
The genotype of homograft kidneys plays the primary role in determining chronic blood pressure levels in two strains of rats with opposite genetically controlled propensities for hyptertension. In hypertensive rats from the hypertension-prone (S) str