Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Martha Grabos"'
Autor:
Farsam Eliat, Rebecca Sohn, Henrik Renner, Theresa Kagermeier, Stefan Volkery, Heike Brinkmann, Nils Kirschnick, Friedemann Kiefer, Martha Grabos, Katharina Becker, Ivan Bedzhov, Hans R. Schöler, Jan M. Bruder
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract In recent years, 3D cell culture has been gaining a more widespread following across many fields of biology. Tissue clearing enables optical analysis of intact 3D samples and investigation of molecular and structural mechanisms by homogenizi
Externí odkaz:
https://doaj.org/article/73f74211564f4e0996b0fbd8dae25874
Autor:
Henrik Renner, Katharina J. Becker, Theresa E. Kagermeier, Martha Grabos, Farsam Eliat, Patrick Günther, Hans R. Schöler, Jan M. Bruder
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Toxicity testing is a crucial step in the development and approval of chemical compounds for human contact and consumption. However, existing model systems often fall short in their prediction of human toxicity in vivo because they may not sufficient
Externí odkaz:
https://doaj.org/article/3fafc522595e473c9de7213b4e759c51
Publikováno v:
Bio-Protocol, Vol 11, Iss 11 (2021)
Three-dimensional cell cultures (“organoids”) promise to better recapitulate native tissue physiology than traditional 2D cultures and are becoming increasingly interesting for disease modeling and compound screening efforts. While a number of pr
Externí odkaz:
https://doaj.org/article/f00fb6a6bba9473594f7951a5e9024e2
Publikováno v:
Bio-Protocol, Vol 11, Iss 12 (2021)
Three-dimensional (3D) cell culture, especially in the form of organ-like microtissues (“organoids”), has emerged as a novel tool potentially mimicking human tissue biology more closely than standard two-dimensional culture. Typically, tissue sec
Externí odkaz:
https://doaj.org/article/034893d320c941ba94cc71c6acf9055b
Autor:
Henrik Renner, Martha Grabos, Katharina J Becker, Theresa E Kagermeier, Jie Wu, Mandy Otto, Stefan Peischard, Dagmar Zeuschner, Yaroslav TsyTsyura, Paul Disse, Jürgen Klingauf, Sebastian A Leidel, Guiscard Seebohm, Hans R Schöler, Jan M Bruder
Publikováno v:
eLife, Vol 9 (2020)
Three-dimensional (3D) culture systems have fueled hopes to bring about the next generation of more physiologically relevant high-throughput screens (HTS). However, current protocols yield either complex but highly heterogeneous aggregates (‘organo
Externí odkaz:
https://doaj.org/article/2662a280e32941548c73b45f5456f1b6
Autor:
George E. Iliakis, Dian Wang, Richard L. Piekarz, Beverly A. Teicher, C. Norman Coleman, Mansoor Ahmed, Mohammad Sharif Mortoga Hasan, Shipra Chaudhary, Lisa Marie Krieger, Martha Grabos, You Wang, Fanghua Li, Aashish Soni
Table S1: Dose Modification Factor at 10% survival in different cell lines. Table S2: List of primary and secondary antibodies. Table S3: Cytotoxicity of different inhibitors in un-irradiated CHO cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b06a0cdca138f63a8bd84c47fc55eab
https://doi.org/10.1158/1535-7163.22505127.v1
https://doi.org/10.1158/1535-7163.22505127.v1
Autor:
George E. Iliakis, Dian Wang, Richard L. Piekarz, Beverly A. Teicher, C. Norman Coleman, Mansoor Ahmed, Mohammad Sharif Mortoga Hasan, Shipra Chaudhary, Lisa Marie Krieger, Martha Grabos, You Wang, Fanghua Li, Aashish Soni
(A) The DR-GFP reporter assay fails to detect an effect of BMN673. (B) BMN673 impairs DSB repair in human sarcoma and rhabdoid cell liines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e45d1852ad4fecaa160ddad26fa3352
https://doi.org/10.1158/1535-7163.22505130.v1
https://doi.org/10.1158/1535-7163.22505130.v1
Autor:
George E. Iliakis, Dian Wang, Richard L. Piekarz, Beverly A. Teicher, C. Norman Coleman, Mansoor Ahmed, Mohammad Sharif Mortoga Hasan, Shipra Chaudhary, Lisa Marie Krieger, Martha Grabos, You Wang, Fanghua Li, Aashish Soni
Parp inhibitors (Parpi) are commonly used as single agents for the management of tumors with homologous recombination repair (HRR) deficiencies, but combination with radiotherapy (RT) is not widely considered due to the modest radiosensitization typi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c9e1192da83a04e62b5b3a9ad80489c
https://doi.org/10.1158/1535-7163.c.6537963.v1
https://doi.org/10.1158/1535-7163.c.6537963.v1
Autor:
Hans R. Schöler, Henrik Renner, Jan M. Bruder, Theresa E Kagermeier, Katharina J Becker, Patrick Günther, Martha Grabos, Farsam Eliat
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Toxicity testing is a crucial step in the development and approval of chemical compounds for human contact and consumption. However, existing model systems often fall short in their prediction of human toxicity in vivo because they may not sufficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3180a922ec425bd8d6ee4e341c3052b
https://doi.org/10.3389/fnmol.2021.715054
https://doi.org/10.3389/fnmol.2021.715054
Publikováno v:
Bio Protoc
Three-dimensional cell cultures (“organoids”) promise to better recapitulate native tissue physiology than traditional 2D cultures and are becoming increasingly interesting for disease modeling and compound screening efforts. While a number of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e244e6c32c45494037af42f1a4ac3f9
https://doi.org/10.21769/bioprotoc.4049
https://doi.org/10.21769/bioprotoc.4049