Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Martha E. Gadd"'
Autor:
Yaqing Qie, Martha E. Gadd, Qing Shao, Tommy To, Andrew Liu, Shuhua Li, Rocio Rivera‐Valentin, Farah Yassine, Hemant S. Murthy, Roxana Dronca, Mohamed A. Kharfan‐Dabaja, Hong Qin, Yan Luo
Publikováno v:
MedComm, Vol 5, Iss 9, Pp n/a-n/a (2024)
Abstract The challenge of disease relapsed/refractory (R/R) remains a therapeutic hurdle in chimeric antigen receptor (CAR) T‐cell therapy, especially for hematological diseases, with chronic lymphocytic leukemia (CLL) being particularly resistant
Externí odkaz:
https://doaj.org/article/2f29030e86d846d6bad6c794841fdd0f
Autor:
Yan Luo, Martha E. Gadd, Yaqing Qie, Andrea Otamendi-Lopez, Jesus E. Sanchez-Garavito, Mieu M. Brooks, Maria J. Ulloa Navas, Tanya Hundal, Shuhua Li, Vanessa K. Jones, Yanyan Lou, Tushar Patel, Roxana Dronca, Mohamed A. Kharfan-Dabaja, Haidong Dong, Alfredo Quinones-Hinojosa, Hong Qin
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 4, Pp 200891- (2024)
Chimeric antigen receptor (CAR) T cell therapy has encountered limited success in solid tumors. The lack of dependable antigens and the immunosuppressive tumor microenvironment (TME) are major challenges. Within the TME, tumor cells along with immuno
Externí odkaz:
https://doaj.org/article/eba59695e4f1498cac886149059c76a1
Publikováno v:
Expert opinion on investigational drugs. 31(2)
Long-term outcome of patients with acute myeloid leukemia (AML) remains dismal, especially for those with high-risk disease or who are refractory to conventional therapy. CAR T-cell therapy provides unique opportunity to improve outcome by specifical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77b84cb08f8c37c6b2377aba992e456
https://pubmed.ncbi.nlm.nih.gov/35051347
https://pubmed.ncbi.nlm.nih.gov/35051347
Autor:
Yenny M, Vanegas, Razan, Mohty, Martha E, Gadd, Yan, Luo, Mahmoud, Aljurf, Hong, Qin, Mohamed A, Kharfan-Dabaja
Publikováno v:
Hematology/Oncology and Stem Cell Therapy. 15
Chimeric antigen receptors (CARs) are synthetic engineered receptors with an antigen recognition domain derived from a high-specificity monoclonal antibody that can target surface molecules on tumor cells. T cells are genetically engineered to expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa1138219c3a9e9cf735adaa7f78cbc
https://doi.org/10.56875/2589-0646.1026
https://doi.org/10.56875/2589-0646.1026
Publikováno v:
Transplantation and cellular therapy. 28(1)
Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in the Western hemisphere. The recent availability of novel targeted therapies, namely Bruton's tyrosine kinase, phosphoinositide-3 kinase, and BCL-2 inhibitors, have revolutionized th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9888bed23b6ce8fb82bf79f6e1cd39c
https://pubmed.ncbi.nlm.nih.gov/34656807
https://pubmed.ncbi.nlm.nih.gov/34656807
Autor:
Yan Luo, Kaihin Lui, Tommy T. To, Andrew liu, Farah Yassine, Mohamed A. Kharfan Dabaja, Martha E. Gadd, Hong Qin
Publikováno v:
Cancer Research. 82:2855-2855
B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in adults with CD19-targeting CAR T-cell therapy showing an excellent initial curative response. However, 10-20% of patients who receive anti-C19 CAR T-cell treatment experience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47140ae114a1eb59eb8e2d5ec0637e04
https://doi.org/10.1158/1538-7445.am2022-2855
https://doi.org/10.1158/1538-7445.am2022-2855
Autor:
Michael A. Kapin, Martha E. Gadd, Mark E. Sanders, James E. Chastain, Nagendra V. Chemuturi, Kerry L. Markwardt, D.C. Dahlin, M. Curtis
Publikováno v:
Experimental Eye Research. 145:58-67
Nepafenac ophthalmic suspensions, 0.1% (NEVANAC®) and 0.3% (ILEVRO™), are topical nonsteroidal anti-inflammatory drug (NSAID) products approved in the United States, Europe and various other countries to treat pain and inflammation associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8524539161addd9c43d00a3f33fbf21
https://doi.org/10.1016/j.exer.2015.10.009
https://doi.org/10.1016/j.exer.2015.10.009
Autor:
Mandar S. Joshi, Mark D. Wewers, John Anthony Bauer, Jennifer E. Huff, Martha E. Gadd, Elliott D. Crouser, Douglas R. Pfeiffer, Mark W. Julian
Publikováno v:
Critical Care Medicine. 32:478-488
Objective This study was designed to determine the role played by the mitochondrial permeability transition in the pathogenesis of mitochondrial damage and dysfunction in a representative systemic organ during the acute phase of endotoxemia. Design A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f0805a18ed0059d45a9fe59d9f907e
https://doi.org/10.1097/01.ccm.0000109449.99160.81
https://doi.org/10.1097/01.ccm.0000109449.99160.81
Autor:
Martha E. Gadd, Gustav Graff, Jitendra Kumar, Nirupama Lal, Warren E. Erdahl, Douglas R. Pfeiffer, John M. Yanni
Publikováno v:
Archives of biochemistry and biophysics. 490(1)
We investigated the effects of several non-steroidal anti-inflammatory drugs on swelling related properties of mitochondria, with an emphasis on compounds that are marketed and utilized topically in the eye (nepafenac, ketorolac, diclofenac, bromfena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9056c36111c71ecd67b79e1441015c
https://pubmed.ncbi.nlm.nih.gov/19810214
https://pubmed.ncbi.nlm.nih.gov/19810214
Autor:
Douglas R. Pfeiffer, Jitendra Kumar, Martha E. Gadd, Elliott D. Crouser, Kimberly M. Broekemeier, Gustav Graff
Publikováno v:
The Journal of biological chemistry. 281(11)
The mitochondrial Ca(2+)-independent phospholipase A(2) is activated during energy-dependent Ca(2+) accumulation under conditions where there is a sustained depression of the membrane potential. This activation is not dependent on induction of the mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064fc0a828aee25993bb6e5551bdb109
https://pubmed.ncbi.nlm.nih.gov/16407316
https://pubmed.ncbi.nlm.nih.gov/16407316