Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Martha E. Floy"'
Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts
Autor:
Charles M. Kerr, Sophia E. Silver, Yi Sun Choi, Martha E. Floy, Amy D. Bradshaw, Seung-Woo Cho, Sean P. Palecek, Ying Mei
Publikováno v:
Bioactive Materials, Vol 31, Iss , Pp 463-474 (2024)
Human induced pluripotent stem cell derived cardiac fibroblasts (hiPSC-CFs) play a critical role in modeling human cardiovascular diseases in vitro. However, current culture substrates used for hiPSC-CF differentiation and expansion, such as Matrigel
Externí odkaz:
https://doaj.org/article/085242f56f0e407293727c5ae5c5b1f0
Autor:
Martha E. Floy, Fathima Shabnam, Sophie E. Givens, Vaidehi A. Patil, Yunfeng Ding, Grace Li, Sushmita Roy, Amish N. Raval, Eric G. Schmuck, Kristyn S. Masters, Brenda M. Ogle, Sean P. Palecek
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Introduction: Fibroblasts are mesenchymal cells that predominantly produce and maintain the extracellular matrix (ECM) and are critical mediators of injury response. In the heart, valve interstitial cells (VICs) are a population of fibroblasts respon
Externí odkaz:
https://doaj.org/article/a537963323944b3b94074d536215d926
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101275- (2022)
Summary: Cardiac fibroblasts (CFBs) are a key therapeutic target due to their supportive roles during heart development and response to injury and disease. Here, we describe a robust protocol to differentiate human pluripotent stem cells (hPSCs) into
Externí odkaz:
https://doaj.org/article/86aa9a32ad564bcc93a8797541293fc3
Publikováno v:
Stem Cell Research, Vol 45, Iss , Pp - (2020)
Coronary heart disease is one of the leading causes of death in the United States. Recent advances in stem cell biology have led to the development and engineering of human pluripotent stem cell (hPSC)-derived cardiac cells and tissues for applicatio
Externí odkaz:
https://doaj.org/article/c37806d945bb4b7a923fd7e0e961e9e0
Autor:
Martha E. Floy, Fathima Shabnam, Aaron D. Simmons, Vijesh J. Bhute, Gyuhyung Jin, Will A. Friedrich, Alexandra B. Steinberg, Sean P. Palecek
Publikováno v:
Annu Rev Chem Biomol Eng
The emergence of human pluripotent stem cell (hPSC) technology over the past two decades has provided a source of normal and diseased human cells for a wide variety of in vitro and in vivo applications. Notably, hPSC-derived cardiomyocytes (hPSC-CMs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a58073eebc97aaaf3a764ef59919bbf
https://doi.org/10.1146/annurev-chembioeng-092120-033922
https://doi.org/10.1146/annurev-chembioeng-092120-033922
Autor:
Alexandra B. Steinberg, Martha E. Floy, Isabella M. Reichardt, Sean P. Palecek, Kaitlin K. Dunn, Taylor D. Mateyka
Publikováno v:
J Mol Cell Cardiol
Epicardial cells (EpiCs) are necessary for myocardium formation, yet little is known about crosstalk between EpiCs and cardiomyocytes (CMs) during development and the potential impact of EpiCs on CM maturation. To investigate the effects of EpiCs on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b64fcce434052b78c905ba176745954
https://europepmc.org/articles/PMC8766908/
https://europepmc.org/articles/PMC8766908/
Publikováno v:
Adv Healthc Mater
Spatiotemporally controlled presentation of morphogens and elaborate modulation of signaling pathways elicit pattern formation during development. Though this process is critical for proper organogenesis, unraveling mechanisms of human developmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e332f9ba4f0239fac7ba4a8cc01fcfd8
https://europepmc.org/articles/PMC8568665/
https://europepmc.org/articles/PMC8568665/
Autor:
Charles M. Kerr, Timothy J. Kamp, Brenda M. Ogle, Martha E. Floy, Alexandra B. Steinberg, Sophie E. Givens, Ana C. Silva, Jianhua Zhang, Ying Mei, Oriane B. Matthys, Sean P. Palecek, Taylor D. Mateyka, Todd C. McDevitt
Publikováno v:
FASEB J
Cardiac fibroblasts (CFBs) support heart function by secreting extracellular matrix (ECM) and paracrine factors, respond to stress associated with injury and disease, and therefore are an increasingly important therapeutic target. We describe how dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720c260a929ef417fe065f264c28359e
https://doi.org/10.1096/fj.202100523r
https://doi.org/10.1096/fj.202100523r
Autor:
J. Zach Hilt, Shuo Tang, Manjula Sunkara, Andrew J. Morris, Rohit Bhandari, Martha E. Floy, Thomas D. Dziubla
Publikováno v:
ACS Omega, Vol 2, Iss 12, Pp 8723-8729 (2017)
ACS Omega
ACS Omega
A novel crosslinker [4,4′-dihydroxybiphenyl diacrylate (44BDA)] was developed, and a series of temperature-responsive hydrogels were synthesized through free radical polymerization of N-isopropylacrylamide (NIPAAm) with 44BDA. The temperature-respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c85aae7ff5273fb64c96abf2944a4f2
https://doi.org/10.1021/acsomega.7b01247
https://doi.org/10.1021/acsomega.7b01247
Autor:
Nathanael P. Gifford, Brian F. Pfleger, Costas D. Maranas, Rung-Yi Lai, James B. Thoden, Daniel Mendez-Perez, Matthew J. Grisewood, Matthew F. Allan, Martha E. Floy, Néstor J. Hernández-Lozada, Haley Schoenberger, Hazel M. Holden
Publikováno v:
ACS Catalysis. 7:3837-3849
Enzyme and metabolic engineering offer the potential to develop biocatalysts for converting natural resources into a wide range of chemicals. To broaden the scope of potential products beyond natural metabolites, methods of engineering enzymes to acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ab995208941d109f72b66445b36ca9
https://doi.org/10.1021/acscatal.7b00408
https://doi.org/10.1021/acscatal.7b00408