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Autor:
Stephen Todd, Irwin D. Kuntz, Robert J. Fletterick, Charles S. Craik, Rilva G. Pinho, Martha C.A. Laboissière, Malin M. Young
Publikováno v:
Journal of Biological Chemistry. 277:26623-26631
Inhibitors of urokinase-type plasminogen activator (uPA) were selected in vitro from two ecotin phage-display libraries to study the effect on binding of amino acid substitutions at critical positions 108, 110, 112, and 113 within the 100s loop (RNKL