Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Martha C. Cone"'
Publikováno v:
ChemBioChem. 4:821-828
Blasticidin S is a potent antifungal and cytotoxic peptidyl nucleoside antibiotic from Streptomyces griseochromogenes. The mixed biosynthesis of the compound is evident from the three distinct structural components: a cytosine base, an amino deoxyglu
Publikováno v:
Tetrahedron. 56:693-701
The final steps in the biosynthesis of the antifungal peptidyl-nucleoside blasticidin S ( 3 ) have been revised to include a novel self-resistance mechanism wherein the previously proposed final precursor, demethylblasticidin S ( 7 ), is modified wit
Publikováno v:
The Journal of Antibiotics. 51:570-578
Two small chromosomal DNA fragments (2.6 and 4.8 kb) from the blasticidin S producer Streptomyces griseochromogenes were cloned in the high copy number vector pIJ702 and shown to confer increased resistance to blasticidin S upon S. lividans TK24. The
Publikováno v:
Tetrahedron. 51:3095-3102
Two new colored metabolites of Streptomyces murayamaensis have been isolated and characterized as 4-hydroxy-3-nitrosobenzamide and its ferrous chelate. These structures have been confirmed by synthesis via a modified Baudisch reaction. A sample of 3-
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:191-194
An X-ray crystallographic analysis revealed that a new metabolite of Streptomyces murayamaensis , murayaanthraquinone, contains a 5-azo-16-oxo-dibenzo[ b , k ]chrysene ring system. This hexacyclic structure has been shown to be a hybrid derived from
Publikováno v:
Journal of Natural Products. 56:1239-1245
Organic extracts of Streptomyces lusitanus, the producer of the anticancer antibiotic naphthyridinomycin [1], were found to contain two additional compounds active in an antibiotic screen. As with 1, these reacted with NaCN added at the end of the fe
Kinafluorenone, a benzo[b]fluorenone isolated from the kinamycin producer Streptomyces murayamaensis
Publikováno v:
The Journal of Organic Chemistry. 58:1058-1061
A strain of Streptomyces murayamaensis blocked in the biosynthesis of the kinamycin antibiotics was obtained by nitrosoguanidine mutagenesis. The major colored metabolite of the mutant strain was characterized by NMR spectroscopy and X-ray crystallog
Publikováno v:
ChemInform. 28
Publikováno v:
ChemInform. 25
Publikováno v:
ChemInform. 26