Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

Autor: Betancourt, Martha C. Castaño, Cailotto, Frederic, Kerkhof, Hanneke J., Cornelis, Frederique M. F., Doherty, Sally A., Hart, Deborah J., Hofman, Albert, Luyten, Frank P., Maciewicz, Rose A., Mangino, Massimo, Metrustry, Sarah, Muir, Kenneth, Peters, Marjolein J., Rivadeneira, Fernando, Wheeler, Maggie, Zhang, Weiya, Arden, Nigel, Spector, Tim D., Uitterlinden, Andre G., Doherty, Michael, Lories, Rik J. U., Valdes, Ana M., van Meurs, Joyce B. J.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2012 May . 109(21), 8218-8223.

Externí odkaz: https://www.jstor.org/stable/41602968

Novel genetic variants for cartilage thickness and hip osteoarthritis

Autor: Weiya Zhang, Michael C. Nevitt, Fernando Rivadeneira, Martha C. Castaño-Betancourt, Elizabeth Barrett-Connor, Yolande F. M. Ramos, Margreet Kloppenburg, Jeroen van Rooij, Deborah J. Hart, Ingrid Meulenbelt, Sarah Metrustry, Michelle S. Yau, Joanne M. Jordan, Evangelos Evangelou, André G. Uitterlinden, Rose A. Maciewicz, Sally Doherty, Unnur Styrkarsdottir, Youfang Liu, Michael Doherty, Robert Kraaij, Ana M. Valdes, Daniel S. Evans, Virginia B. Kraus, Tim D. Spector, Wouter den Hollander, Braxton D. Mitchell, Kenneth Muir, Albert Hofman, Eleftheria Zeggini, Cindy G. Boer, Rob G H H Nelissen, Eline Slagboom, Nigel K Arden, Floris P J G Lafeber, Nancy E Lane, Joyce B. J. van Meurs

Publikováno v: PLoS Genetics, 12(10). Public Library of Science
PLoS genetics, vol 12, iss 10
Castaño-Betancourt, MC; Evans, DS; Ramos, YFM; Boer, CG; Metrustry, S; Liu, Y; et al.(2016). Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis. PLoS Genetics, 12(10), e1006260. doi: 10.1371/journal.pgen.1006260. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/89m303gq
Castaño-Betancourt, M C, Evans, D S, Ramos, Y F M, Boer, C G, Metrustry, S, Liu, Y, den Hollander, W, van Rooij, J, Kraus, V B, Yau, M S, Mitchell, B D, Muir, K, Hofman, A, Doherty, M, Doherty, S, Zhang, W, Kraaij, R, Rivadeneira, F, Barrett-Connor, E, Maciewicz, R A, Arden, N, Nelissen, R G H H, Kloppenburg, M, Jordan, J M, Nevitt, M C, Slagboom, E P, Hart, D J, Lafeber, F, Styrkarsdottir, U, Zeggini, E, Evangelou, E, Spector, T D, Uitterlinden, A G, Lane, N E, Meulenbelt, I, Valdes, A M & van Meurs, J B J 2016, ' Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis ', PL o S Genetics, vol. 12, no. 10, e1006260 . https://doi.org/10.1371/journal.pgen.1006260
PLoS Genetics
PLoS Genetics, Vol 12, Iss 10, p e1006260 (2016)
PLoS Genetics (online), 12(10):e1006260. Public Library of Science
PLoS Genetics, 12(10)

Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, we here examined carti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421d735bbcfdbb2608d30e36a9dc4b98
http://ora.ox.ac.uk/objects/uuid:

The contribution of hip geometry to the prediction of hip osteoarthritis

Autor: Jan H. Waarsing, J.B. van Meurs, A. Hofman, Martha C. Castaño-Betancourt, A.G. Uitterlinden, Fernando Rivadeneira, Harrie Weinans, S.M.A. Bierma-Zeinstra

Publikováno v: Osteoarthritis and Cartilage, 21(10), 1530-1536. W.B. Saunders

Summary Objective To determine how well measures of hip geometry can predict radiological incident hip osteoarthritis (HOA) compared to well known clinical risk factors. Design The study population is part of the Rotterdam Study, a prospective popula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de291af41a0c4a21480e3ee72179265a
https://doi.org/10.1016/j.joca.2013.06.012

Bone parameters across different types of hip osteoarthritis and their relationship to osteoporotic fracture risk

Autor: André G. Uitterlinden, Hanneke J. M. Kerkhof, Sita M A Bierma-Zeinstra, Martha C. Castaño-Betancourt, Joyce B. J. van Meurs, Albert Hofman, Fernando Rivadeneira

Publikováno v: Arthritis & Rheumatism, 65(3), 693-700. John Wiley & Sons Ltd.

Objective The atrophic type of hip osteoarthritis (OA) is characterized by cartilage degradation without the formation of osteophytes. Individuals with atrophic OA have been less well studied, and it is unknown whether this OA type differs from the o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7b4ba974715102f80307c00246dd8d
https://hdl.handle.net/1765/54316

[Educating health workers is key in congenital syphilis elimination in Colombia]

Autor: Elizabeth Benavides, Martha C. Castaño, Adriana R. Cruz, Juan Pablo Garcés, Yenifer Orobio, Luisa Rubiano

Publikováno v: Biomédica, Volume: 37, Issue: 3, Pages: 416-424, Published: SEP 2017
Biomédica: revista del Instituto Nacional de Salud, Vol 37, Iss 3, Pp 416-424 (2017)

Resumen Introducción. Para la prevención de la transmisión materno-infantil de la sífilis en Colombia, se promueve el diagnóstico y el tratamiento en una sola consulta mediante el uso de pruebas de diagnóstico rápido, así como programas de el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae10bd3697c57e27290bb63fe90a00b9
https://pubmed.ncbi.nlm.nih.gov/28968019