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Pancreatic stone protein predicts positive sputum bacteriology in exacerbations of copd

Autor: Daiana Stolz, Andreas Scherr, Beat Müller, Michael Tamm, Mirjam Christ-Crain, Rolf Graf, Martha Bain

Publikováno v: Chest

BACKGROUND: Pancreatic Stone Protein/regenerating protein (PSP/reg) is supposed to be increased in bacterial inflammation. PSP/reg might therefore be also useful as a predictor of bacterial infection in COPD. METHODS: 200 consecutive patients present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4675e6ab40bc08a6e639999d7d7638bf

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Inflammation-dependent expression of SPARC during development of chronic pancreatitis in WBN/Kob rats and a microarray gene expression analysis

Autor: S Y Kim, Theresia Reding, U Wagner, Rolf Graf, Li-Kang Sun, Martha Bain, Daniel Bimmler, Alberto B. Silva

Publikováno v: Physiological Genomics. 38:196-204

The pathophysiology of human chronic pancreatitis is not well understood and difficult to follow on a molecular basis. Therefore, we used a rat model [Wistar-Bonn/Kobori (WBN/Kob)] that exhibits spontaneous chronic inflammation and fibrosis in the pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90ce640c1031d10d15c8712aa333a2f
https://doi.org/10.1152/physiolgenomics.00028.2009

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Pancreatic stone protein as an early biomarker predicting mortality in a prospective cohort of patients with sepsis requiring ICU management

Autor: Thierry Calandra, Frederik Delodder, Yok-Ai Que, Idris Guessous, Martha Bain, Rolf Graf, Lucas Liaudet, Philippe Eggimann

Publikováno v: Critical Care, Vol. 16, No 4 (2012) P. R114
Critical care (London England)
Critical Care
Critical Care, vol. 16, no. 4, pp. R114

INTRODUCTION: Biomarkers, such as C-reactive protein [CRP] and procalcitonin [PCT], are insufficiently sensitive or specific to stratify patients with sepsis. We investigate the prognostic value of pancreatic stone protein/regenerating protein (PSP/r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9075220b626b25d78dab2b0abe01c087
https://archive-ouverte.unige.ch/unige:31872

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COX-2 is not required for the development of murine chronic pancreatitis

Autor: Martha Bain, Theresia Reding, Alberto B. Silva, Achim Weber, Sabrina Sonda, Rolf Graf, Mathias Heikenwalder

Publikováno v: Am. J. Physiol. Gastrointest. Liver Physiol. 300, G968-G975 (2011)

Chronic pancreatitis is a severe inflammation of the pancreas associated with destruction of the parenchyma, fibrosis, and persistent abdominal pain. Cyclooxygenase-2 (COX-2) and COX-2-derived prostaglandins, key mediators of the inflammatory respons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00c981d818e2c50d07bf18f15113d06
https://pubmed.ncbi.nlm.nih.gov/21372163

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Distribution of macrophages and T cells in syngrafts and allografts after experimental rat lung transplantation

Autor: Wolfgang Jungraithmayr, Walter Weder, Stephan Korom, Sven Hillinger, Ilhan Inci, Martha Bain

Publikováno v: Immunobiology. 215(3)

Macrophages and T cells have a pivotal role in orchestrating the acute lung allograft rejection response. We investigated the spatial and temporal distribution of these immune cells and the synthesis patterns of the T(h)1- and T(h)2-cytokine IL-12 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a7237e402d26aa538126fd4853e664
https://pubmed.ncbi.nlm.nih.gov/19457578

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Prostaglandin E2 modulates TNF-alpha-induced MCP-1 synthesis in pancreatic acinar cells in a PKA-dependent manner

Autor: Rolf Graf, Theresia Reding, Martha Bain, Li-Kang Sun, Mathias Heikenwalder, Daniel Bimmler

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology. 293(6)

Cyclooxygenase (COX)-2 is increased in human chronic pancreatitis. We recently demonstrated in a model of chronic pancreatitis (WBN/Kob rat) that inhibition of COX-2 activity reduces and delays pancreatic inflammation and fibrosis. Monocyte chemoattr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3677a86fdda7f307bf81c14c3f6070
https://pubmed.ncbi.nlm.nih.gov/17916652

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