Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Martha Campbell-Thompson"'
Autor:
Juan Francisco Morales, Marian Klose, Yannick Hoffert, Jagdeep T. Podichetty, Jackson Burton, Stephan Schmidt, Klaus Romero, Inish O'Doherty, Frank Martin, Martha Campbell‐Thompson, Michael J. Haller, Mark A. Atkinson, Sarah Kim
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1309-1316 (2024)
Abstract Clinical trials seeking to delay or prevent the onset of type 1 diabetes (T1D) face a series of pragmatic challenges. Despite more than 100 years since the discovery of insulin, teplizumab remains the only FDA‐approved therapy to delay pro
Externí odkaz:
https://doaj.org/article/8b4ca31b57414e94973b9675f895a590
Autor:
Sanghoon Kang, Jesus D. Penaloza Aponte, Omar Elashkar, Juan Francisco Morales, Nicholas Waddington, Damon G. Lamb, Huiwen Ju, Martha Campbell-Thompson, Sarah Kim
Publikováno v:
Journal of Pathology Informatics, Vol 16, Iss , Pp 100406- (2025)
Human islets display a high degree of heterogeneity in terms of size, number, architecture, and endocrine cell-type compositions. An ever-increasing number of immunohistochemistry-stained whole slide images (WSIs) are available through the online pat
Externí odkaz:
https://doaj.org/article/660ad83bad1f4876826152406bc1b8ef
Autor:
Brittany Sorensen Bruggeman, Savanna Gornisiewicz, Rhonda Bacher, Kieran McGrail, Martha Campbell-Thompson, Clive Wasserfall, Laura M. Jacobsen, Mark Atkinson, Michael J. Haller, Desmond A. Schatz
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionThe immune-mediated destruction of insulin-producing β-cells characterizes type 1 diabetes. Nevertheless, exocrine pancreatic enzymes, including amylase, lipase, and trypsin, are also significantly reduced in type 1 diabetes. With an imm
Externí odkaz:
https://doaj.org/article/37dc74c374bb4a699cf8e4f23a3cdf92
Autor:
Juan Francisco Morales, Rhoda Muse, Jagdeep T. Podichetty, Jackson Burton, Sarah David, Patrick Lang, Stephan Schmidt, Klaus Romero, Inish O'Doherty, Frank Martin, Martha Campbell‐Thompson, Michael J. Haller, Mark A. Atkinson, Sarah Kim
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 7, Pp 1016-1028 (2023)
Abstract Clinical trials seeking type 1 diabetes prevention are challenging in terms of identifying patient populations likely to progress to type 1 diabetes within limited (i.e., short‐term) trial durations. Hence, we sought to improve such effort
Externí odkaz:
https://doaj.org/article/f29e4953b25f4d88b03fbbb1b32d2233
Autor:
Daniel J. Perry, Melanie R. Shapiro, Sonya W. Chamberlain, Irina Kusmartseva, Srikar Chamala, Leandro Balzano-Nogueira, Mingder Yang, Jason O. Brant, Maigan Brusko, MacKenzie D. Williams, Kieran M. McGrail, James McNichols, Leeana D. Peters, Amanda L. Posgai, John S. Kaddis, Clayton E. Mathews, Clive H. Wasserfall, Bobbie-Jo M. Webb-Robertson, Martha Campbell-Thompson, Desmond Schatz, Carmella Evans-Molina, Alberto Pugliese, Patrick Concannon, Mark S. Anderson, Michael S. German, Chester E. Chamberlain, Mark A. Atkinson, Todd M. Brusko
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-16 (2023)
Abstract The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest biorepository of human pancreata and associated immune organs from donors with type 1 diabetes (T1D), maturity-onset diabetes of the young (MODY), cystic fibrosis-re
Externí odkaz:
https://doaj.org/article/0ad4cb66140840c5abd02c69201bad7b
Autor:
Jinmai Jiang, Hesamedin Hakimjavadi, Julie K. Bray, Corey Perkins, Alyssa Gosling, Lais daSilva, Gamze Bulut, Jamel Ali, V. Wendy Setiawan, Martha Campbell-Thompson, Srikar Chamala, Thomas D. Schmittgen
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 4, Pp 532-543 (2023)
Background and Aims: Aberrant acinar to ductal metaplasia (ADM), one of the earliest events involved in exocrine pancreatic cancer development, is typically studied using pancreata from genetically engineered mouse models. Methods: We used primary, h
Externí odkaz:
https://doaj.org/article/e719570951944b93bfcff08dd212e1c9
Autor:
Lais da Silva, Jinmai Jiang, Corey Perkins, Kalina Rosenova Atanasova, Julie K. Bray, Gamze Bulut, Ana Azevedo-Pouly, Martha Campbell-Thompson, Xiaozhi Yang, Hesamedin Hakimjavadi, Srikar Chamala, Ranjala Ratnayake, Raad Z. Gharaibeh, Chenglong Li, Hendrik Luesch, Thomas D. Schmittgen
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Pancreatic acinar cells display a remarkable degree of plasticity and can dedifferentiate into ductal-like progenitor cells by a process known as acinar ductal metaplasia (ADM). ADM is believed to be one of the earliest precursor lesions tow
Externí odkaz:
https://doaj.org/article/7f68709dca8b439d9401f8575221c64b
Autor:
Martha Campbell-Thompson, Elizabeth A. Butterworth, J. Lucas Boatwright, Malavika A. Nair, Lith H. Nasif, Kamal Nasif, Andy Y. Revell, Alberto Riva, Clayton E. Mathews, Ivan C. Gerling, Desmond A. Schatz, Mark A. Atkinson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Dysregulation of glucagon secretion in type 1 diabetes (T1D) involves hypersecretion during postprandial states, but insufficient secretion during hypoglycemia. The sympathetic nervous system regulates glucagon secretion. To investigate isle
Externí odkaz:
https://doaj.org/article/06c0546e7343448f81538ebc42c845a0
Autor:
Pascal de Boer, Nicole M. Pirozzi, Anouk H. G. Wolters, Jeroen Kuipers, Irina Kusmartseva, Mark A. Atkinson, Martha Campbell-Thompson, Ben N. G. Giepmans
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Type 1 diabetes is associated with autoimmune destruction of pancreatic beta-cells. Here the authors compose a large-scale electron microscopy image data base of pancreatic organ donor tissue to enable data mining and further understanding of the dis
Externí odkaz:
https://doaj.org/article/b384446e156a477db4af65825afe3aac
Autor:
Klaus H. Kaestner, Martha Campbell–Thompson, Yuval Dor, Ronald G. Gill, Benjamin Glaser, Seung K. Kim, Maike Sander, Cherie Stabler, Andrew F. Stewart, Alvin C. Powers
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101323- (2021)
Background: The pancreatic β cell, as the sole source of the vital hormone insulin, has been under intensive study for more than a century. Given the potential of newly created insulin-producing cells as a treatment or even cure of type 1 diabetes (
Externí odkaz:
https://doaj.org/article/176e01f999a345899f3c242dc7786c64