Integrated Single-cell and Plasma Proteomic Modeling to Predict Surgical Site Complications: A Prospective Cohort Study

Autor: Kristen K. Rumer, Julien Hedou, Amy Tsai, Jakob Einhaus, Franck Verdonk, Natalie Stanley, Benjamin Choisy, Edward Ganio, Adam Bonham, Danielle Jacobsen, Beata Warrington, Xiaoxiao Gao, Martha Tingle, Tiffany N. McAllister, Ramin Fallahzadeh, Dorien Feyaerts, Ina Stelzer, Dyani Gaudilliere, Kazuo Ando, Andrew Shelton, Arden Morris, Electron Kebebew, Nima Aghaeepour, Cindy Kin, Martin S. Angst, Brice Gaudilliere

Publikováno v: Ann Surg

OBJECTIVE: To determine whether single-cell and plasma proteomic elements of the host’s immune response to surgery accurately identifies patients who develop a Surgical Site Complication (SSC) after major abdominal surgery. SUMMARY BACKGROUND DATA:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ccb9abe9fa6f062878a93d77873a53
https://doi.org/10.1097/sla.0000000000005348

Multiomics Characterization of Preterm Birth in Low- and Middle-Income Countries

Autor: Tarik Hasan, Stephen R. Quake, Ivana Maric, Abdul Quaiyum, Jennifer Winston, Anisur Rahman, Nabidul H. Chowdhury, Gary L. Darmstadt, Kévin Contrepois, Alexander Manu, Patrick Musonda, Said M. Ali, Ramin Fallahzadeh, Jeffrey S. A. Stringer, Paul H. Wise, James A Litch, Eileen S. Tsai, Dipak Kumar Mitra, Mira N. Moufarrej, Edward A. Ganio, Candace Liu, Waqasuddin Khan, Ghaith Bany Hammad, Martin S. Angst, Fyezah Jehan, Aneeta Hotwani, Usma Mehmood, Rajiv Bahl, Alan L. Chang, Mohammad Sajjad Ghaemi, Arup Dutta, Sayedur Rahman, Michael Snyder, Salahuddin Ahmed, Ronald S. Gibbs, Syed Jafar Raza Rizvi, Stillbirth, Maurice L. Druzin, Natalie Stanley, Arif Mahmud, Rasheda Khanam, Sunil Sazawal, Furqan Kabir, Ronald J. Wong, Gary M. Shaw, Martha Tingle, Fahad Aftab, Aishwarya Chauhan, Usha Dhingra, Maria Xenochristou, Jeffrey C. Murray, David K. Stevenson, Shaali M. Ame, Amy S. Tsai, Cecele C. Quaintance, Jesmin Pervin, Muhammad Imran Nisar, Mohammed Hamad Juma, Songjie Chen, Muhammad Ilyas, Martin Becker, Sajid Muhammad, Sayan Das, Saikat Deb, Dyani Gaudilliere, Brice Gaudilliere, Anthony Culos, Ambreen Nizar, Nima Aghaeepour, Ina A. Stelzer, Alliance for Maternal, Sachiyo Yoshida, Camilo Espinosa, Mamun Ibne Moin, Nazma Begum, Javairia Khalid, Kazuo Ando, Virginia D. Winn, Xiaoyuan Han, Abdullah H Baqui

Publikováno v: JAMA Network Open

This diagnostic/prognostic study describes the use of cell-free transcriptomics, urine metabolomics, and plasma proteomics for identifying the biological measurements associated with preterm birth.
Key Points Question What maternal biological mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab2bad6e546c83df1dc19dd903b8a47
http://europepmc.org/articles/PMC7749442

Systemic Immunologic Consequences of Chronic Periodontitis

Autor: Brice Gaudilliere, Anthony Culos, Basile Bertrand, Jill A. Helms, Benjamin Choisy, Martin S. Angst, Ramin Fallahzadeh, Jakob Einhaus, Edward A. Ganio, Kazuo Ando, Quentin Baca, Athena Tanada, Natalie Stanley, T. Alpagot, William Choi, Nima Aghaeepour, Xiaoyuan Han, Dyani Gaudilliere, Mohammad Sajjad Ghaemi, Karim Djebali, Martha Tingle, Amy S. Tsai, Robin Okada, A. Maghaireh, Julien Hedou

Publikováno v: J Dent Res

Chronic periodontitis (ChP) is a prevalent inflammatory disease affecting 46% of the US population. ChP produces a profound local inflammatory response to dysbiotic oral microbiota that leads to destruction of alveolar bone and tooth loss. ChP is als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a8d3373304d0032eaa90ef80ee350b
https://pubmed.ncbi.nlm.nih.gov/31226001

Implementing Mass Cytometry at the Bedside to Study the Immunological Basis of Human Diseases: Distinctive Immune Features in Patients with a History of Term or Preterm Birth

Autor: Quentin Baca, David K. Stevenson, Martin S. Angst, Gary M. Shaw, Martha Tingle, Nima Aghaeepour, Edward A. Ganio, Yasser Y. El-Sayed, Brice Gaudilliere, Garry P. Nolan, Gabriela K. Fragiadakis, Cele Quaintance, David B. Lewis, Ronald J. Wong, Hope L. Lancero

Publikováno v: Cytometry Part A. 87:817-829

Single-cell technologies have immense potential to shed light on molecular and biological processes that drive human diseases. Mass cytometry (or Cytometry by Time Of Flight mass spectrometry, CyTOF) has already been employed in clinical studies to c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4092dbfc1c8e56dd1011d75eb93681e
https://doi.org/10.1002/cyto.a.22720

An immune clock of human pregnancy

Autor: Maurice L. Druzin, Gary L. Darmstadt, Sofie Van Gassen, Martha Tingle, Virginia D. Winn, David K. Stevenson, Quentin Baca, Robin Okada, Nima Aghaeepour, Garry P. Nolan, Leslie McNeil, David B. Lewis, Ronald J. Wong, David Furman, Yaser Y. El-Sayed, Amy S. Tsai, Martin S. Angst, Mohammad Sajjad Ghaemi, Robert Tibshirani, Edward A. Ganio, Ronald S. Gibbs, Gary M. Shaw, Brice Gaudilliere, David R. McIlwain, Dyani Gaudilliere, Cecele C. Quaintance

Publikováno v: SCIENCE IMMUNOLOGY

The maintenance of pregnancy relies on finely tuned immune adaptations. We demonstrate that these adaptations are precisely timed, reflecting an immune clock of pregnancy in women delivering at term. Using mass cytometry, the abundance and functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d447b459eb55f56f4b6fc4741e35bc
https://biblio.ugent.be/publication/8550731