Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice

Autor: Patrick W. B. Derksen, Tanya M. Braumuller, Eline van der Burg, Marten Hornsveld, Elly Mesman, Jelle Wesseling, Paul Krimpenfort, Jos Jonkers

Publikováno v: Disease Models & Mechanisms, Vol 4, Iss 3, Pp 347-358 (2011)

SUMMARY Breast cancer is the most common malignancy in women of the Western world. Even though a large percentage of breast cancer patients show pathological complete remission after standard treatment regimes, approximately 30–40% are non-responsi

Externí odkaz: https://doaj.org/article/8512f67f5a4f43cdbd394077728fdf09

Figure S2 from FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression

Autor: Tobias B. Dansen, Boudewijn M.T. Burgering, Patrick W.B. Derksen, Frank C.P. Holstege, David E.A. Kloet, Dik van Leenen, Marian J.A. Groot Koerkamp, Miranda van Amersfoort, Maaike Meerlo, Lydia M.M. Smits, Marten Hornsveld

Foxo1, Foxo3 and Foxo4 expression levels and depletion in mILC1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486df4821b0612a86041d79572dff22a
https://doi.org/10.1158/0008-5472.22418277.v1

Data from FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression

Autor: Tobias B. Dansen, Boudewijn M.T. Burgering, Patrick W.B. Derksen, Frank C.P. Holstege, David E.A. Kloet, Dik van Leenen, Marian J.A. Groot Koerkamp, Miranda van Amersfoort, Maaike Meerlo, Lydia M.M. Smits, Marten Hornsveld

FOXO transcription factors are regulators of cellular homeostasis and putative tumor suppressors, yet the role of FOXO in cancer progression remains to be determined. The data on FOXO function, particularly for epithelial cancers, are fragmentary and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db8b3011558dc8b797465c7493abf2b0
https://doi.org/10.1158/0008-5472.c.6510081.v1

Supplemental Figures from FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression

Autor: Tobias B. Dansen, Boudewijn M.T. Burgering, Patrick W.B. Derksen, Frank C.P. Holstege, David E.A. Kloet, Dik van Leenen, Marian J.A. Groot Koerkamp, Miranda van Amersfoort, Maaike Meerlo, Lydia M.M. Smits, Marten Hornsveld

Figure S1. Immunohistochemistry analysis of mILC1-iFOXO3.A3 tumors & primary tumor size upon detection of metastasis. Figure S2. Foxo1, Foxo3 and Foxo4 expression levels and depletion in mILC1. Figure S3. Immunohistochemistry analysis of mILC1-shFOXO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f843f8eeb46fd9a7eb9cc76f0bcb08e
https://doi.org/10.1158/0008-5472.22418244.v1

SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells

Autor: Lilian M. Sluimer, Esme Bullock, Max A. K. Rätze, Lotte Enserink, Celine Overbeeke, Marten Hornsveld, Valerie G. Brunton, Patrick W. B. Derksen, Sandra Tavares

Publikováno v: Sluimer, L, Bullock, E, Ratze, M, Enserink, L, Overbeeke, C, Hornsveld, M, Brunton, V G, Derksen, P W B & Tavares, S 2023, ' SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells ', Journal of Cell Science, vol. 136, no. 3, jcs260243 . https://doi.org/10.1242/jcs.260243

High expression of the tyrosine kinase FER is an independent prognostic factor that correlates with poor survival in breast cancer patients. To investigate whether the kinase activity is essential for FER oncogenic properties, we developed an ATP ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a50db47529209457c83fae573feae8
https://www.pure.ed.ac.uk/ws/files/320926987/SKOR1_mediates_FER_kinase_dependent_invasive_growth_of_breast_cancer_cells_AAM.pdf