Výsledky vyhledávání - "Marten F Snel"

Akademický článek

FAST-IT: Find A Simple Test — In TIA (transient ischaemic attack): a prospective cohort study to develop a multivariable prediction model for diagnosis of TIA through proteomic discovery and candidate lipid mass spectrometry, neuroimaging and machine learning—study protocol

Autor: Timothy Kleinig, Suzanne Edwards, Monica Anne Hamilton-Bruce, Sushma R Rao, Marten F Snel, Paul J Trim, Simon A Koblar, Mark Jenkinson, Austin G Milton, Stephan Lau, Karlea L Kremer, Emilie Mas, Deeksha Sharma, Erik Noschka

Publikováno v: BMJ Open, Vol 12, Iss 4 (2022)

Introduction Transient ischaemic attack (TIA) may be a warning sign of stroke and difficult to differentiate from minor stroke and TIA-mimics. Urgent evaluation and diagnosis is important as treating TIA early can prevent subsequent strokes. Recent i

Externí odkaz: https://doaj.org/article/78a7eae8819d46eaaba51e0f04fe929b

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Akademický článek

Developing a multivariable prediction model for functional outcome after reperfusion therapy for acute ischaemic stroke: study protocol for the Targeting Optimal Thrombolysis Outcomes (TOTO) multicentre cohort study

Autor: Elizabeth Holliday, Timothy Kleinig, Thomas Lillicrap, Philip M C Choi, Jane Maguire, Andrew Bivard, Lisa F Lincz, Monica Anne Hamilton-Bruce, Sushma R Rao, Marten F Snel, Paul J Trim, Longting Lin, Mark W Parsons, Bradford B Worrall, Simon Koblar, Chris Levi

Publikováno v: BMJ Open, Vol 10, Iss 4 (2020)

Introduction Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) is the only approved pharmacological reperfusion therapy for acute ischaemic stroke. Despite population benefit, IVT is not equally effective in all pat

Externí odkaz: https://doaj.org/article/52c12dd6078c40b0b864537c9c00a0d6

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Akademický článek

Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)

Abstract We implicated the X-chromosome THOC2 gene, which encodes the largest subunit of the highly-conserved TREX (Transcription-Export) complex, in a clinically complex neurodevelopmental disorder with intellectual disability as the core phenotype.

Externí odkaz: https://doaj.org/article/f655e25df84a4da1addb5bf08b495565

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Akademický článek

The role of oxidised self-lipids and alveolar macrophage CD1b expression in COPD

Autor: Miranda P. Ween, Jake B. White, Hai B. Tran, Violet Mukaro, Charles Jones, Matthew Macowan, Gregory Hodge, Paul J. Trim, Marten F. Snel, Sandra J. Hodge

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract In chronic obstructive pulmonary disease (COPD) apoptotic bronchial epithelial cells are increased, and their phagocytosis by alveolar macrophages (AM) is decreased alongside bacterial phagocytosis. Epithelial cellular lipids, including thos

Externí odkaz: https://doaj.org/article/78d884c250684b168035f4d76956f5ac

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Akademický článek

AAVrh10 Vector Corrects Disease Pathology in MPS IIIA Mice and Achieves Widespread Distribution of SGSH in Large Animal Brains

Autor: Michaël Hocquemiller, Kim M. Hemsley, Meghan L. Douglass, Sarah J. Tamang, Daniel Neumann, Barbara M. King, Helen Beard, Paul J. Trim, Leanne K. Winner, Adeline A. Lau, Marten F. Snel, Cathy Gomila, Jérôme Ausseil, Xin Mei, Laura Giersch, Mark Plavsic, Ralph Laufer

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 174-187 (2020)

Patients with mucopolysaccharidosis type IIIA (MPS IIIA) lack the lysosomal enzyme sulfamidase (SGSH), which is responsible for the degradation of heparan sulfate (HS). Build-up of undegraded HS results in severe progressive neurodegeneration for whi

Externí odkaz: https://doaj.org/article/dc201b70e27746bcae02d970deb12fca

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Akademický článek

Increased Alveolar Heparan Sulphate and Reduced Pulmonary Surfactant Amount and Function in the Mucopolysaccharidosis IIIA Mouse

Autor: Tamara L. Paget, Emma J. Parkinson-Lawrence, Paul J. Trim, Chiara Autilio, Madhuriben H. Panchal, Grielof Koster, Mercedes Echaide, Marten F. Snel, Anthony D. Postle, Janna L. Morrison, Jésus Pérez-Gil, Sandra Orgeig

Publikováno v: Cells, Vol 10, Iss 4, p 849 (2021)

Mucopolysaccharidosis IIIA (MPS IIIA) is a lysosomal storage disease with significant neurological and skeletal pathologies. Respiratory dysfunction is a secondary pathology contributing to mortality in MPS IIIA patients. Pulmonary surfactant is cruc

Externí odkaz: https://doaj.org/article/303771f4fc134b0c98d59b93b6277ab1

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Equivalent Carbon Number and Interclass Retention Time Conversion Enhance Lipid Identification in Untargeted Clinical Lipidomics

Autor: Jake B. White, Paul J. Trim, Thalia Salagaras, Aaron Long, Peter J. Psaltis, Johan W. Verjans, Marten F. Snel

Publikováno v: Analytical Chemistry. 94:3476-3484

Chromatography is often used as a method for reducing sample complexity prior to analysis by mass spectrometry, and the use of retention time (RT) is becoming increasingly popular to add valuable supporting information in lipid identification. The RT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c6522bba12674ebb03aa732d7b3a46
https://doi.org/10.1021/acs.analchem.1c03770

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