Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells

Autor: Marten A. Fischer, Al-Hassan M. Mustafa, Kristin Hausmann, Ramy Ashry, Anita G. Kansy, Magdalena C. Liebl, Christina Brachetti, Andrea Piée-Staffa, Matthes Zessin, Hany S. Ibrahim, Thomas G. Hofmann, Mike Schutkowski, Wolfgang Sippl, Oliver H. Krämer

Publikováno v: Journal of Advanced Research, Vol 60, Iss , Pp 201-214 (2024)

Introduction: Posttranslational modification of proteins by reversible acetylation regulates key biological processes. Histone deacetylases (HDACs) catalyze protein deacetylation and are frequently dysregulated in tumors. This has spurred the develop

Externí odkaz: https://doaj.org/article/0bdd50c9fd09429e928b1f2b75be1138

Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity

Autor: Hany S. Ibrahim, Mohamed Abdelsalam, Yanira Zeyn, Matthes Zessin, Al-Hassan M. Mustafa, Marten A. Fischer, Patrik Zeyen, Ping Sun, Emre F. Bülbül, Anita Vecchio, Frank Erdmann, Matthias Schmidt, Dina Robaa, Cyril Barinka, Christophe Romier, Mike Schutkowski, Oliver H. Krämer, Wolfgang Sippl

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 23 (1), pp.369. ⟨10.3390/ijms23010369⟩
International Journal of Molecular Sciences, Vol 23, Iss 369, p 369 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 369

Class I histone deacetylases (HDACs) are key regulators of cell proliferation and they are frequently dysregulated in cancer cells. We report here the synthesis of a novel series of class-I selective HDAC inhibitors (HDACi) containing a 2-aminobenzam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5223ab0a6c7f524d71ccd174413edaa1
https://hal.science/hal-03821847/document