ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling

Autor: Maximilian Hirschenberger, Alice Lepelley, Ulrich Rupp, Susanne Klute, Victoria Hunszinger, Lennart Koepke, Veronika Merold, Blaise Didry-Barca, Fanny Wondany, Tim Bergner, Tatiana Moreau, Mathieu P. Rodero, Reinhild Rösler, Sebastian Wiese, Stefano Volpi, Marco Gattorno, Riccardo Papa, Sally-Ann Lynch, Marte G. Haug, Gunnar Houge, Kristen M. Wigby, Jessica Sprague, Jerica Lenberg, Clarissa Read, Paul Walther, Jens Michaelis, Frank Kirchhoff, Carina C. de Oliveira Mann, Yanick J. Crow, Konstantin M. J. Sparrer

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Abstract Type I interferon (IFN) signalling is tightly controlled. Upon recognition of DNA by cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the endoplasmic reticulum (ER)-Golgi axis to induce IFN signalling

Externí odkaz: https://doaj.org/article/b099f69003f848078aba66c1696bcd67

Gut microbiota is associated with dietary intake and metabolic markers in healthy individuals

Autor: Line Gaundal, Mari C. W. Myhrstad, Ida Rud, Terje Gjøvaag, Marte G. Byfuglien, Kjetil Retterstøl, Kirsten B. Holven, Stine M. Ulven, Vibeke H. Telle-Hansen

Publikováno v: Food & Nutrition Research, Vol 66, Pp 1-14 (2022)

Background: Metabolic diseases have been related to gut microbiota, and new knowledge indicates that diet impacts host metabolism through the gut microbiota. Identifying specific gut bacteria associated with both diet and metabolic risk markers may b

Externí odkaz: https://doaj.org/article/8260f716c25749998cc86306acb6e3a7

Postprandial changes in gene expression of cholesterol influx and efflux mediators after intake of SFA compared with n-6 PUFA in subjects with and without familial hypercholesterolaemia: secondary outcomes of a randomised controlled trial

Autor: Linn K. L. Øyri, Ingunn Narverud, Martin P. Bogsrud, Patrik Hansson, Lena Leder, Marte G. Byfuglien, Marit B. Veierød, Magne Thoresen, Stine M. Ulven, Kirsten B. Holven

Publikováno v: Journal of Nutritional Science, Vol 8 (2019)

The long-term cholesterol-lowering effect of replacing intake of SFA with PUFA is well established, but has not been fully explained mechanistically. We examined the postprandial response of meals with different fat quality on expression of lipid gen

Externí odkaz: https://doaj.org/article/242bccb3bec64ce0816a7b6e2598aaf6

Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study

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Publikováno v: In The Lancet Oncology November 2021 22(11):1507-1517

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