Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Marta Westwood"'
Autor:
Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D Taylor, Tim Norman, John Porter, Lorna C Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H Sullivan, David Fox, Mark D Carr, Alistair Henry, Richard Taylor, Beat H Meier, Hartmut Oschkinat, Alastair D Lawson
Publikováno v:
PLoS Biology, Vol 16, Iss 5, p e2006192 (2018)
Aiming at the design of an allosteric modulator of the neonatal Fc receptor (FcRn)-Immunoglobulin G (IgG) interaction, we developed a new methodology including NMR fragment screening, X-ray crystallography, and magic-angle-spinning (MAS) NMR at 100 k
Externí odkaz:
https://doaj.org/article/8aa07cda1edf4eacba469577557c2556
Autor:
Marta Westwood, Christian Ottmann, M.A. Redhead, Lorenzo Soini, Seppe Leysen, Jeremy Martin Davis
Publikováno v:
RSC Medicinal Chemistry, 12(9), 1555-1564. Royal Society of Chemistry
RSC Medicinal Chemistry
RSC Medicinal Chemistry
The stabilisation of protein–protein interactions (PPIs) through molecular glues is a novel and promising approach in drug discovery. In stark contrast to research in protein–protein inhibition the field of stabilisation remains underdeveloped wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911b7804707c9a84f8af126ef7e535cb
https://doi.org/10.1039/d1md00172h
https://doi.org/10.1039/d1md00172h
Autor:
Marta Westwood, Alastair D. G. Lawson
Publikováno v:
Antibodies, Vol 4, Iss 3, Pp 170-196 (2015)
Assembly of misfolded proteins into fibrillar deposits is a common feature of many neurodegenerative diseases. Developing effective therapies to these complex, and not yet fully understood diseases is currently one of the greatest medical challenges
Externí odkaz:
https://doaj.org/article/cf4b8aef622a4f0aabef945cb862658a
Autor:
Kaushik, Sarkar, Lisa, Joedicke, Marta, Westwood, Rebecca, Burnley, Michael, Wright, David, McMillan, Bernadette, Byrne
Publikováno v:
Vitamins and hormones. 120
Parathyroid hormone receptor 1 (PTH1R) is a class B G-protein coupled receptor with key roles in bone development. The receptor signals through both the G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::34897ee55cc65f968c534cac4feb71e7
https://pubmed.ncbi.nlm.nih.gov/35953107
https://pubmed.ncbi.nlm.nih.gov/35953107
Autor:
Kaushik Sarkar, Lisa Joedicke, Marta Westwood, Rebecca Burnley, Michael Wright, David McMillan, Bernadette Byrne
Publikováno v:
Vitamins and Hormones ISBN: 9780323992251
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::501ded9b0835148e30dd2c6177fcf9be
https://doi.org/10.1016/bs.vh.2022.04.002
https://doi.org/10.1016/bs.vh.2022.04.002
Autor:
Kamal Ivory, Andrew M Wilson, Prasanna Sankaran, Marta Westwood, Justin McCarville, Claire Brockwell, Allan Clark, Jack R Dainty, Laurian Zuidmeer-Jongejan, Claudio Nicoletti
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78650 (2013)
To determine effects of probiotic consumption on clinical and immunological parameters of seasonal allergic rhinitis (SAR) in an out-of-season single nasal allergen challenge.In a study registered at ClinicalTrials.Gov (NCT01123252), a 16-week dietar
Externí odkaz:
https://doaj.org/article/4f1a26f1f01c4f24ab0cba30f430d25a
Autor:
Berni Sweeney, Marta Westwood, Kerry Louise Tyson, David McMillan, Geofrey Odede, Gillian Burgess, Terry Baker, Daniel John Lightwood, Patrick Downey, Georges Mairet-Coello, Rebecca Munro, Martin Citron, Robert G. Griffin, Dale Starkie, Marie-Laetitia Mushikiwabo, Nathalie Pacico, Ruodan Nan, Sophie Jung, Rachel Angers, Jean-Philippe Courade, Andrew George Popplewell
Publikováno v:
Acta Neuropathologica
In Alzheimer’s disease (AD) and other tauopathies, the cytosolic protein Tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration. Clinical progression is tightly linked to the progressive sprea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67c24541a714f957c1f3282bf1205ce
https://doi.org/10.1007/s00401-018-1911-2
https://doi.org/10.1007/s00401-018-1911-2
Autor:
Lisa Joedicke, David McMillan, Rebecca J. Burnley, Bernadette Byrne, Marta Westwood, Kaushik Sarkar, Michael John Wright
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Parathyroid hormone receptor 1 (PTH1R) belongs to the secretin class of G protein coupled receptors (GPCRs) and natively binds parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP). Ligand binding to PTH1R involves binding to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab29a5fb6d133f89674926079ef393b
https://pubmed.ncbi.nlm.nih.gov/31594997
https://pubmed.ncbi.nlm.nih.gov/31594997
Publikováno v:
Carbohydrate Polymers. 89:1222-1231
A quartz crystal microbalance with dissipation monitoring (QCMD) has been used to monitor the adsorption and structure of lysozyme monolayers and multilayers, and poly-L-lysine (PLL)-polygalacturonic acid (PGalA) multilayers at a solid-liquid interfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da649ca357a016e2ebd5e74ffb24cea
https://doi.org/10.1016/j.carbpol.2012.03.097
https://doi.org/10.1016/j.carbpol.2012.03.097
Publikováno v:
Carbohydrate Polymers. 84:960-969
The action of polygalacturonase on layer-by-layer deposited multilayer films composed of poly- l -lysine and polygalacturonic acid was examined using a quartz crystal microbalance with dissipation monitoring (QCMD), dual polarisation interferometry (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b862735d3789296092e3054d4bf0656b
https://doi.org/10.1016/j.carbpol.2010.12.051
https://doi.org/10.1016/j.carbpol.2010.12.051