Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Marta W Szulik"'
Autor:
Enrique Balderas, David R. Eberhardt, Sandra Lee, John M. Pleinis, Salah Sommakia, Anthony M. Balynas, Xue Yin, Mitchell C. Parker, Colin T. Maguire, Scott Cho, Marta W. Szulik, Anna Bakhtina, Ryan D. Bia, Marisa W. Friederich, Timothy M. Locke, Johan L. K. Van Hove, Stavros G. Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R. Rodan, Dipayan Chaudhuri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Mitochondrial complex I deficiency is frequent in congenital, neurologic and cardiovascular disease. Here the authors demonstrate that Complex I stimulates the turnover of a mitochondrial calcium channel, which becomes stabilized during Complex I def
Externí odkaz:
https://doaj.org/article/c2ef9f77a9ef4d22aad9d8b4d27239a7
Autor:
Enrique Balderas, David R. Eberhardt, Sandra Lee, John M. Pleinis, Salah Sommakia, Anthony M. Balynas, Xue Yin, Mitchell C. Parker, Colin T. Maguire, Scott Cho, Marta W. Szulik, Anna Bakhtina, Ryan D. Bia, Marisa W. Friederich, Timothy M. Locke, Johan L. K. Van Hove, Stavros G. Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R. Rodan, Dipayan Chaudhuri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/375509dbb57e4c128813f2aea63a1296
Autor:
Marta W. Szulik, Steven Valdez, Maureen Walsh, Kathryn Davis, Ryan Bia, Emilee Horiuchi, Sean O’Very, Anil K. Laxman, Linda Sandaklie-Nicolova, David R. Eberhardt, Jessica R. Durrant, Hanin Sheikh, Samuel Hickenlooper, Magnus Creed, Cameron Brady, Mickey Miller, Li Wang, June Garcia-Llana, Christopher Tracy, Stavros G. Drakos, Katsuhiko Funai, Dipayan Chaudhuri, Sihem Boudina, Sarah Franklin
Publikováno v:
Basic Research in Cardiology. 118
SMYD1, a striated muscle-specific lysine methyltransferase, was originally shown to play a key role in embryonic cardiac development but more recently we demonstrated that loss of Smyd1 in the murine adult heart leads to cardiac hypertrophy and failu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::734bfb8a4c8bfb31aca6f3cd4ae62421
https://doi.org/10.1007/s00395-023-00991-6
https://doi.org/10.1007/s00395-023-00991-6
Autor:
Marta W. Szulik, Miguel Reyes-Múgica, Daniel F. Marker, Ana M. Gomez, Matthew D. Zinn, Leslie K. Walsh, Juan Pablo Ochoa, Sarah Franklin, Lina Ghaloul-Gonzalez
Publikováno v:
Genes; Volume 14; Issue 3; Pages: 659
Mutations in cardiac genes are one of the primary causes of infantile cardiomyopathy. In this study, we report the genetic findings of two siblings carrying variations in the MYBPC3 and SMYD1 genes. The first patient is a female proband exhibiting hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da033753914bffca09275741fc1d279c
Autor:
Marta W Szulik, Steven Valdez, Maureen Walsh, Kathryn Davis, Ryan Bia, Emilee Horiuchi, Sean O'Very, Anil Laxman, Linda Nicolova, Hanin Sheikh, Samuel Hickenlooper, Mickey R Miller, Li Wang, June Garcia-Llano, Christopher Tracy, Stavros G Drakos, Katsuhiko Funai, Dipayan Chaudhuri, Sihem Boudina, Sarah Franklin
Publikováno v:
Circulation Research. 131
The histone lysine methyltransferase SMYD1 has been shown to be critical for embryonic cardiac development and in maintaining cardiomyocyte homeostasis in adult mice. Subsequently, we reported that loss of Smyd1 in the adult mouse myocardium leads to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0241e7b5d812c1c512af9ab85bebb83
https://doi.org/10.1161/res.131.suppl_1.p3088
https://doi.org/10.1161/res.131.suppl_1.p3088
Autor:
Samuel M. Hickenlooper, Kathryn Davis, Marta W. Szulik, Hanin Sheikh, Mickey Miller, Steven Valdez, Ryan Bia, Sarah Franklin
Publikováno v:
ACS Omega. 8:6124-6125
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::503ad74ebf4178ebaa770361e876644f
https://doi.org/10.1021/acsomega.3c00112
https://doi.org/10.1021/acsomega.3c00112
Autor:
Samuel M. Hickenlooper, Kathryn Davis, Hanin Sheikh, Mickey Miller, Ryan Bia, Steven Valdez, Marta W. Szulik, Sarah Franklin
Publikováno v:
ACS omega. 7(35)
Heart disease is the leading cause of death in the developed world, and its comorbidities such as hypertension, diabetes, and heart failure are accompanied by major transcriptomic changes in the heart. During cardiac dysfunction, which leads to heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80456c056b17257dc2f94622a36b526d
https://pubmed.ncbi.nlm.nih.gov/36092581
https://pubmed.ncbi.nlm.nih.gov/36092581
Publikováno v:
Circulation Research. 129
It has been well established that many cardiac pathologies result from dynamic changes in gene expression and conversely that modulating key epigenetic factors in murine models is capable of preventing or abrogating ischemic injury and pathological r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bede862d490f398b2d1fad56c897b704
https://doi.org/10.1161/res.129.suppl_1.p499
https://doi.org/10.1161/res.129.suppl_1.p499
Publikováno v:
Circulation Research. 129
Among the metabolic shifts in chronic heart failure is a dysregulation of purine metabolism, which has been shown to negatively impact patient outcomes, especially in individuals affected by hypertension, diabetes, and congestive heart failure, via i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0e1340189a291ffbf37a0dae770290
https://doi.org/10.1161/res.129.suppl_1.p513
https://doi.org/10.1161/res.129.suppl_1.p513
Autor:
Maureen Walsh, Sarah Franklin, Katsuhiko Funai, Garcia-Llano June, Marta W. Szulik, Ryan Bia, Anil Laxman, Dipayan Chaudhuri, Mickey R. Miller, Emilee Horiuchi, Christopher M. Tracy, Sihem Boudina, Steven Valdez, Sean A. O’Very, Li Wang, Kathryn Davis, Stavros G. Drakos
Publikováno v:
Circulation Research. 129
SMYD1a, a myosin-specific histone lysine methyltransferase, plays a major role in regulating disease-induced remodeling in the adult heart. Previously, we demonstrated that the inducible loss of this chromatin-bound enzyme is sufficient to induce car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceba04ceb5b3cb44d98bd74e06b21150
https://doi.org/10.1161/res.129.suppl_1.p340
https://doi.org/10.1161/res.129.suppl_1.p340