Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation

Autor: Matthew Y. Tang, Marta Vranas, Andrea I. Krahn, Shayal Pundlik, Jean- François Trempe, Edward A. Fon

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Parkin and PINK1 are involved in damaged mitochondria clearance; however the sequence of events of Parkin activation is not clear. Here, the authors show that binding to phospho-ubiquitin on mitochondria enables Parkin phosphorylation, which allows R

Externí odkaz: https://doaj.org/article/b55f87d3a9934780bd5addb22763e47c

Author response for 'Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria'

Autor: null Marta Vranas, null Yang Lu, null Shafqat Rasool, null Nathalie Croteau, null Jonathan D. Krett, null Véronique Sauvé, null Kalle Gehring, null Edward A. Fon, null Thomas M. Durcan, null Jean-François Trempe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3caa8a530387006eec62962d8247e942
https://doi.org/10.1098/rsob.210255/v2/response1

Selective localization of Mfn2 near PINK1 enable its preferential ubiquitination by Parkin on mitochondria

Autor: Nathalie Croteau, Marta Vranas, Thomas M. Durcan, Jean-François Trempe, Yang Lu, Shafqat Rasool, Kalle Gehring, Edward A. Fon, Véronique Sauvé, Jonathan D. Krett

Publikováno v: Open Biology, Vol 12, Iss 1 (2022)
Open Biology

Mutations in Parkin and PINK1 cause an early-onset familial Parkinson’s disease. Parkin is a RING-In-Between-RING (RBR) E3 ligase that transfers ubiquitin from an E2 enzyme to a substrate in two steps: 1) thioester intermediate formation on Parkin,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406592d827eb6d6ee358619a9ded031f
https://doi.org/10.1101/2021.08.25.457684

A Ubl/ubiquitin switch in the activation of Parkin

Autor: Jimin Wang, Tara Sprules, Marta Vranas, Asparouh Lilov, Kalle Gehring, Marjan Seirafi, Shafqat Rasool, Véronique Sauvé, Guennadi Kozlov, Jean-François Trempe

Publikováno v: The EMBO Journal. 34:2492-2505

Mutations in Parkin and PINK1 cause an inherited early-onset form of Parkinson's disease. The two proteins function together in a mitochondrial quality control pathway whereby PINK1 accumulates on damaged mitochondria and activates Parkin to induce m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c3191056155d13418be6244d6440398
https://doi.org/10.15252/embj.201592237

Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death

Autor: Paula L. Hedley, Elijah R. Behr, Göran Wettrell, Mads Toft Søndergaard, Marta Vranas, Jacob Lund, Lasse Hildebrandt, A. John Camm, Anders D. Børglum, Mette Nyegaard, Michael Toft Overgaard, Michael Christiansen, Inger Fosdal

Publikováno v: Nyegaard, M, Overgaard, M T, Sondergaard, M T, Vranas, M, Behr, E R, Hildebrandt, L L, Lund, J, Hedley, P L, Camm, A J, Wettrell, G, Fosdal, I, Christiansen, M & Borglum, A D 2012, ' Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death ', American Journal of Human Genetics, vol. 91, no. 4, pp. 703-712 . https://doi.org/10.1016/j.ajhg.2012.08.015
Nyegaard, M, Overgaard, M T, Søndergaard, M, Vranas, M, Behr, E R, Hildebrandt, L, Lund, J, Hedley, P L, Camm, A J, Wettrell, G, Fosdal, I, Christiansen, M & Børglum, A D 2012, ' Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death ', American Journal of Human Genetics, vol. 91, no. 4, pp. 703-12 . https://doi.org/10.1016/j.ajhg.2012.08.015

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a devastating inherited disorder characterized by episodic syncope and/or sudden cardiac arrest during exercise or acute emotion in individuals without structural cardiac abnormalities.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8ce6c5ae7b05c1dab76b2685fb8593
https://vbn.aau.dk/da/publications/ff068879-fc21-466e-b9d7-89f137b13d24