FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

Autor: Teresa, Brevini, Mailis, Maes, Gwilym J, Webb, Binu V, John, Claudia D, Fuchs, Gustav, Buescher, Lu, Wang, Chelsea, Griffiths, Marnie L, Brown, William E, Scott, Pehuén, Pereyra-Gerber, William T H, Gelson, Stephanie, Brown, Scott, Dillon, Daniele, Muraro, Jo, Sharp, Megan, Neary, Helen, Box, Lee, Tatham, James, Stewart, Paul, Curley, Henry, Pertinez, Sally, Forrest, Petra, Mlcochova, Sagar S, Varankar, Mahnaz, Darvish-Damavandi, Victoria L, Mulcahy, Rhoda E, Kuc, Thomas L, Williams, James A, Heslop, Davide, Rossetti, Olivia C, Tysoe, Vasileios, Galanakis, Marta, Vila-Gonzalez, Thomas W M, Crozier, Johannes, Bargehr, Sanjay, Sinha, Sara S, Upponi, Corrina, Fear, Lisa, Swift, Kourosh, Saeb-Parsy, Susan E, Davies, Axel, Wester, Hannes, Hagström, Espen, Melum, Darran, Clements, Peter, Humphreys, Jo, Herriott, Edyta, Kijak, Helen, Cox, Chloe, Bramwell, Anthony, Valentijn, Christopher J R, Illingworth, Bassam, Dahman, Dustin R, Bastaich, Raphaella D, Ferreira, Thomas, Marjot, Eleanor, Barnes, Andrew M, Moon, Alfred S, Barritt, Ravindra K, Gupta, Stephen, Baker, Anthony P, Davenport, Gareth, Corbett, Vassilis G, Gorgoulis, Simon J A, Buczacki, Joo-Hyeon, Lee, Nicholas J, Matheson, Michael, Trauner, Andrew J, Fisher, Paul, Gibbs, Andrew J, Butler, Christopher J E, Watson, George F, Mells, Gordon, Dougan, Andrew, Owen, Ansgar W, Lohse, Ludovic, Vallier, Fotios, Sampaziotis

Publikováno v: Nature. 615:134-142

Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting enzyme 2 (ACE2)1, could represent a new chemoprophylactic approach for COVID-19 that complements vaccination2,3. However, the mechanisms that control t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d1f48c490c312e0492b836b250c36f
https://doi.org/10.1038/s41586-022-05594-0

FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome

Autor: Olivia C. Tysoe, Andrew M. Moon, Paul Gibbs, Sally Forrest, Sanjay Sinha, Johannes Bargehr, Daniele Muraro, Sidney A Barritt, William Gelson, Gwilym J. Webb, Eleanor Barnes, Mailis Maes, Stephen Baker, Gareth Corbett, Thomas L Williams, Gordon Dougan, Vasileios Galanakis, Ravindra K. Gupta, Fotios Sampaziotis, Scott Dillon, Ludovic Vallier, Lisa Swift, Teresa Brevini, Andrew J. Butler, Mahnaz Darvish-Damavandi, Sara Upponi, Ansgar W. Lohse, George F. Mells, Kourosh Saeb-Parsy, Simon J.A. Buczacki, Marta Vila-Gonzalez, Victoria L. Mulcahy, Susan E. Davies, Sagar Varankar, Thomas Marjot, Petra Mlcochova, Christopher J.E. Watson, Anthony P. Davenport, Joo-Hyeon Lee, Thomas W M Crozier, Rhoda E. Kuc

Prevention of SARS-CoV-2 entry in cells through the modulation of viral host receptors, such as ACE2, could represent a new therapeutic approach complementing vaccination. However, the mechanisms controlling ACE2 expression remain elusive. Here, we i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67bbf5a5471abdb9a98cd836cdc4ceac
https://doi.org/10.1101/2021.06.06.446781

The RNA-binding protein QKI controls alternative splicing in vascular cells, producing an effective model for therapy

Autor: Rachel, Caines, Amy, Cochrane, Sophia, Kelaini, Marta, Vila-Gonzalez, Chunbo, Yang, Magdalini, Eleftheriadou, Arya, Moez, Alan W, Stitt, Lingfang, Zeng, David J, Grieve, Andriana, Margariti

Publikováno v: Journal of cell science. 132(16)

Dysfunction of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) leads to ischaemia, the central pathology of cardiovascular disease. Stem cell technology will revolutionise regenerative medicine, but a need remains to understand key m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::488e25c526d408b30e70dee2096ba87b
https://pubmed.ncbi.nlm.nih.gov/31331967

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions

Autor: Amelie V, Guitart, Theano I, Panagopoulou, Arnaud, Villacreces, Milica, Vukovic, Catarina, Sepulveda, Lewis, Allen, Roderick N, Carter, Louie N, van de Lagemaat, Marcos, Morgan, Peter, Giles, Zuzanna, Sas, Marta Vila, Gonzalez, Hannah, Lawson, Jasmin, Paris, Joy, Edwards-Hicks, Katrin, Schaak, Chithra, Subramani, Deniz, Gezer, Alejandro, Armesilla-Diaz, Jimi, Wills, Aaron, Easterbrook, David, Coman, Chi Wai Eric, So, Donal, O'Carroll, Douglas, Vernimmen, Neil P, Rodrigues, Patrick J, Pollard, Nicholas M, Morton, Andrew, Finch, Kamil R, Kranc

Publikováno v: Guitart, A V, Panagopoulou, T I, Villacreces, A, Vukovic, M, Sepulveda, C, Allen, L, Carter, R N, van de Lagemaat, L N, Morgan, M, Giles, P, Sas, Z, Gonzalez, M V, Lawson, H, Paris, J, Edwards-Hicks, J, Schaak, K, Subramani, C, Gezer, D, Armesilla-Diaz, A, Wills, J, Easterbrook, A, Coman, D, So, C W E, O'Carroll, D, Vernimmen, D, Rodrigues, N P, Pollard, P J, Morton, N M, Finch, A & Kranc, K R 2017, ' Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions ', The Journal of experimental medicine, vol. 214, no. 3, pp. 719-735 . https://doi.org/10.1084/jem.20161087
The Journal of Experimental Medicine

Guitart et al. performed an in vivo genetic dissection of the Krebs cycle enzyme fumarate hydratase (Fh1) in the hematopoietic system. Their investigations revealed multifaceted functions of Fh1 in the regulation of hematopoietic stem cell biology an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b414ecb67ecfd079f28382a9e58a2a5b
https://kclpure.kcl.ac.uk/en/publications/606e0f65-93b1-4f5f-9846-41292a145066