Determination of the Global Pattern of Gene Expression in Yeast Cells by Intracellular Levels of Guanine Nucleotides

Autor: Andy Hesketh, Marta Vergnano, Stephen G. Oliver

Publikováno v: mBio, Vol 10, Iss 1 (2019)

ABSTRACT Correlations between gene transcription and the abundance of high-energy purine nucleotides in Saccharomyces cerevisiae have often been noted. However, there has been no systematic investigation of this phenomenon in the absence of confoundi

Externí odkaz: https://doaj.org/article/4251ae1fe01b4de7838458d6ecbdcaf5

IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis

Autor: Siew Eng Choon, Jonathan Barker, Marika Catapano, Francesca Capon, Satveer K. Mahil, Marco Romano, Marta Vergnano, Francesca D. Ciccarelli, Catherine H. Smith, Helen S. Young, Ian M. Carr, Helen J. Lachmann, Giovanna Lombardi, A. David Burden

Publikováno v: Catapano, M, Vergnano, M, Romano, M, Mahil, S K, Choon, S-E, Burden, A D, Young, H S, Carr, I M, Lachmann, H J, Lombardi, G, Smith, C H, Ciccarelli, F D, Barker, J N & Capon, F 2020, ' IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis ', Journal of Investigative Dermatology, vol. 140, no. 4, pp. 816-826.e3 . https://doi.org/10.1016/j.jid.2019.08.444
Catapano, M, Vergnano, M, Romano, M, Mahil, S K, Choon, S, Burden, A D, Young, H S, Carr, I M, Lachmann, H J, Lombardi, G, Smith, C H, Ciccarelli, F D, Barker, J N & Capon, F 2019, ' IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis ', Journal of Investigative Dermatology . https://doi.org/10.1016/j.jid.2019.08.444
The Journal of Investigative Dermatology

Psoriasis is an immune-mediated skin disorder associated with severe systemic co-morbidities. While IL-36 is a key disease driver, the pathogenic role of this cytokine has mainly been investigated in skin. Thus, its effects on systemic immunity and e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0094e8743762a15d4130d9678753bbf6
https://kclpure.kcl.ac.uk/ws/files/120745846/Interleukin_36_promotes_systemic_Acc6Aug2019Epub17Sept2019_GREEN_AAM.pdf

Loss-of-function myeloperoxidase mutations are associated with increased neutrophil counts and pustular skin disease

Autor: Marta Vergnano, Maja Mockenhaupt, Natashia Benzian-Olsson, Maren Paulmann, Katarzyna Grys, Satveer K. Mahil, Charlotte Chaloner, Ines A. Barbosa, Suzannah August, A. David Burden, Siew-Eng Choon, Hywel Cooper, Alex A. Navarini, Nick J. Reynolds, Shyamal Wahie, Richard B. Warren, Andrew Wright, Ulrike Huffmeier, Patrick Baum, Sudha Visvanathan, Jonathan N. Barker, Catherine H. Smith, Francesca Capon, Thamir Abraham, Mahmud Ali, David Baudry, Anthony Bewley, Christopher E.M. Griffiths, John Ingram, Susan Kelly, Mohsen Korshid, Effie Ladoyanni, John McKenna, Freya Meynell, Richard Parslew, Prakash Patel, Angela Pushparajah, Nick Reynolds, Catherine Smith, Richard Warren

Publikováno v: Hueffmeier, U, Baum, P, Visvanathan, S & Barker, J N & Smith, C H 2020, ' Loss-of-function myeloperoxidase mutations are associated with increased neutrophil counts and pustular skin disease ', American Journal of Human Genetics, vol. 107, no. 3, pp. 539-543 . https://doi.org/10.1016/j.ajhg.2020.06.020
APRICOT and PLUM study team 2020, ' Loss-of-Function Myeloperoxidase Mutations Are Associated with Increased Neutrophil Counts and Pustular Skin Disease ', American Journal of Human Genetics . https://doi.org/10.1016/j.ajhg.2020.06.020
American Journal of Human Genetics

The identification of disease alleles underlying human autoinflammatory diseases can provide important insights into the mechanisms that maintain neutrophil homeostasis. Here, we focused our attention on generalized pustular psoriasis (GPP), a potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393991be26bba806e91f9482c1f48e5f
https://doi.org/10.1016/j.ajhg.2021.03.001