Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Marta Valle-León"'
Autor:
Marc López-Cano, Josep Argerich, Marta Valle-León, Alejandro Fernández-Solanas, Víctor Fernández-Dueñas
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S958- (2023)
Externí odkaz:
https://doaj.org/article/e09bf47a18bf4853bf025edf61985233
Autor:
Marta Valle-León, Nil Casajuana-Martin, Claudia Llinas del Torrent, Josep Argerich, Laura Gómez-Acero, Kristoffer Sahlholm, Sergi Ferré, Leonardo Pardo, Francisco Ciruela
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 160, Iss , Pp 114327- (2023)
The striatal dopamine D2 receptor (D2R) is generally accepted to be involved in positive symptoms of schizophrenia and is a main target for clinically used antipsychotics. D2R are highly expressed in the striatum, where they form heteromers with the
Externí odkaz:
https://doaj.org/article/719ba51101504107881ca2cf73a00e28
Autor:
Viktor Burström, Richard Ågren, Nibal Betari, Marta Valle-León, Emilio Garro-Martínez, Francisco Ciruela, Kristoffer Sahlholm
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The dopamine D4 receptor (D4R) is expressed in the retina, prefrontal cortex, and autonomic nervous system and has been implicated in attention deficit hyperactivity disorder (ADHD), substance use disorders, and erectile dysfunction. D4R has also bee
Externí odkaz:
https://doaj.org/article/e4ac71b4fef348f685b291cd35bd0afc
Autor:
René A. J. Crans, Elise Wouters, Marta Valle-León, Jaume Taura, Caio M. Massari, Víctor Fernández-Dueñas, Christophe P. Stove, Francisco Ciruela
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/137c8a0904b543838a2edd3f05da1ad5
Autor:
René A. J. Crans, Elise Wouters, Marta Valle-León, Jaume Taura, Caio M. Massari, Víctor Fernández-Dueñas, Christophe P. Stove, Francisco Ciruela
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor control deficits, which is associated with the loss of striatal dopaminergic neurons from the substantia nigra. In parallel to dopaminergic denervation, there is an inc
Externí odkaz:
https://doaj.org/article/d78fedc97b28444c849c62f284c7c02b
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Pridopidine is in clinical trials for Huntington's disease treatment. Originally developed as a dopamine D2 receptor (D2R) ligand, pridopidine displays about 100-fold higher affinity for the sigma-1 receptor (sigma-1R). Interestingly, pridopidine slo
Externí odkaz:
https://doaj.org/article/f4f1e74e03a74135872feee1cd020e42
Autor:
Xavier Morató, Víctor Fernández-Dueñas, Pilar Pérez-Villamor, Marta Valle-León, José Miguel Vela, Manuel Merlos, Javier Burgueño, Francisco Ciruela
Publikováno v:
ACS Chemical Neuroscience.
The σ1 receptor (S1R) is a ligand-regulated non-opioid intracellular receptor involved in several pathological conditions. The development of S1R-based drugs as therapeutic agents is a challenge due to the lack of simple functional assays to identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84df6b6cc475154e42ca53adaff2f0b
https://doi.org/10.1021/acschemneuro.3c00206
https://doi.org/10.1021/acschemneuro.3c00206
Autor:
Luisa Bandeira Binder, Caio M. Massari, Marc López-Cano, Francisco Ciruela, Leandra C. Constantino, Marta Valle-León, Víctor Fernández-Dueñas, Carla I. Tasca, Naiani Ferreira Marques
Publikováno v:
Purinergic Signalling. 16:379-387
Parkinson’s disease (PD) signs and symptoms regularly include tremor. Interestingly, the nucleoside guanosine (GUO) has already proven to be effective in reducing reserpine-induced tremulous jaw movements (TJMs) in rodent models, thus becoming a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4495734e3f13e3f4e84886b4a2360ce6
https://doi.org/10.1007/s11302-020-09716-z
https://doi.org/10.1007/s11302-020-09716-z
Publikováno v:
Neuromethods ISBN: 9781071615218
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::834458521155db6a362545c850783e79
https://doi.org/10.1007/978-1-0716-1522-5_10
https://doi.org/10.1007/978-1-0716-1522-5_10
Autor:
Marta, Valle-León, Luis F, Callado, Ester, Aso, María M, Cajiao-Manrique, Kristoffer, Sahlholm, Marc, López-Cano, Concepció, Soler, Xavier, Altafaj, Masahiko, Watanabe, Sergi, Ferré, Víctor, Fernández-Dueñas, José M, Menchón, Francisco, Ciruela
Publikováno v:
Neuropsychopharmacology
According to the adenosine hypothesis of schizophrenia, the classically associated hyperdopaminergic state may be secondary to a loss of function of the adenosinergic system. Such a hypoadenosinergic state might either be due to a reduction of the ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea3d90cf319eecd77beaceb345ace7d4
https://pubmed.ncbi.nlm.nih.gov/33010795
https://pubmed.ncbi.nlm.nih.gov/33010795