Phagocytosis in the retina promotes local insulin production in the eye

Autor: J. Iker Etchegaray, Shannon Kelley, Kristen Penberthy, Laura Karvelyte, Yosuke Nagasaka, Sofia Gasperino, Soumen Paul, Vikram Seshadri, Michael Raymond, Ana Royo Marco, Jonathan Pinney, Marta Stremska, Brady Barron, Christopher Lucas, Nishikant Wase, Yong Fan, Emil Unanue, Bijoy Kundu, Tal Burstyn-Cohen, Justin Perry, Jayakrishna Ambati, Kodi S. Ravichandran

Publikováno v: Etchegaray, J I, Kelley, S, Penberthy, K K, Karvelyte, L, Nagasaka, Y, Gasperino, S, Paul, S, Seshadri, V, Raymond, M H, Marco, A R, Pinney, J, Stremska, M E, Barron, B, Lucas, C D, Wase, N, Fan, Y, Unanue, E, Kundu, B, Burstyn-Cohen, T, Perry, J S A, Jayakrishna, A & Ravichandran, K S 2023, ' Phagocytosis in the retina promotes local insulin production in the eye ', Nature Metabolism . https://doi.org/10.1038/s42255-022-00728-0

The retina is highly metabolically active, relying on glucose uptake and aerobic glycolysis. Situated in close contact to photoreceptors, a key function of cells in the retinal pigment epithelium (RPE) is phagocytosis of damaged photoreceptor outer s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e015ab2ee76d21aacd3289ac8c786341
https://doi.org/10.1038/s42255-022-00728-0

Regulation of organ-specific inflammation by CXCR5 during systemic autoimmunity (BA13P.131)

Autor: Rahul Sharma, Christian Abaya, Poonam Sharma, Marta Stremska, Sheethal Jose

Publikováno v: The Journal of Immunology. 192:177.17-177.17

Mice and humans deficient in the Foxp3+ T regulatory cells (Tregs) develop systemic autoimmunity affecting multiple organs and die prematurely. Mice deficient for interleukin (IL)-2 (IL2KO) have reduced Tregs and develop inflammation mainly in liver,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de8c43dcbcfd316ee3078416fcb5da51
https://doi.org/10.4049/jimmunol.192.supp.177.17