Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Marta Spodzieja"'
Autor:
Karolina Wojciechowicz, Katarzyna Kuncewicz, Jacek Rutkowski, Jacek Jassem, Sylwia Rodziewicz-Motowidło, Anna Wardowska, Marta Spodzieja
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116675- (2024)
The complex of B- and T-lymphocyte attenuator (BTLA) and herpes virus entry mediator (HVEM) plays a critical role in immune regulation and has emerged as a promising therapeutic target for cancer treatment. In this study, we investigated the potentia
Externí odkaz:
https://doaj.org/article/5dfae8d23e55421994ded3eab209b991
Autor:
Karolina Wojciechowicz, Katarzyna Kuncewicz, Jacek Rutkowski, Jacek Jassem, Anna Wardowska, Marta Spodzieja
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe effector function of T cells is regulated via immune checkpoints, activating or inhibiting the immune response. The BTLA-HVEM complex, the inhibitory immune checkpoint, may act as one of the tumor immune escape mechanisms. Therefore,
Externí odkaz:
https://doaj.org/article/95f6d24fdd1141448d7f04dd8fa0a2e0
Autor:
Magdalena Bojko, Katarzyna Węgrzyn, Emilia Sikorska, Piotr Ciura, Claire Battin, Peter Steinberger, Katarzyna Magiera-Mularz, Grzegorz Dubin, Adam Kulesza, Adam K. Sieradzan, Marta Spodzieja, Sylwia Rodziewicz-Motowidło
Publikováno v:
Translational Oncology, Vol 42, Iss , Pp 101892- (2024)
The PD-1/PD-L1 complex belongs to the group of inhibitory immune checkpoints and plays a critical role in immune regulation. The PD-1/PD-L1 axis is also responsible for immune evasion of cancer cells, and this complex is one of the main targets of im
Externí odkaz:
https://doaj.org/article/f56500fd70e44f229e66c4fb54d021eb
Autor:
Paula Roszczenko-Jasińska, Artur Giełdoń, Dominika Mazur, Marta Spodzieja, Maciej Plichta, Cezary Czaplewski, Wojciech Bal, Elzbieta K. Jagusztyn-Krynicka, Dariusz Bartosik
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2024)
Introduction:Helicobacter pylori is a bacterium that colonizes the gastric epithelium, which affects millions of people worldwide. H. pylori infection can lead to various gastrointestinal diseases, including gastric adenocarcinoma and mucosa-associat
Externí odkaz:
https://doaj.org/article/1b628f976fc34003815c9fe63d50ded5
Autor:
Katarzyna Kuncewicz, Magdalena Bojko, Claire Battin, Agnieszka Karczyńska, Adam Sieradzan, Emilia Sikorska, Katarzyna Węgrzyn, Karolina Wojciechowicz, Anna Wardowska, Peter Steinberger, Sylwia Rodziewicz-Motowidło, Marta Spodzieja
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115161- (2023)
Immune checkpoints can be divided into co-stimulatory and co-inhibitory molecules that regulate the activation and effector functions of T cells. The co-inhibitory pathways mediated by ICPs are used by cancer cells to escape from immune surveillance,
Externí odkaz:
https://doaj.org/article/871470036cfc451ab2904d5eaa053c2c
Autor:
Anna M. Banaś, Katarzyna M. Bocian-Ostrzycka, Stanisław Dunin-Horkawicz, Jan Ludwiczak, Piotr Wilk, Marta Orlikowska, Agnieszka Wyszyńska, Maria Dąbrowska, Maciej Plichta, Marta Spodzieja, Marta A. Polańska, Agata Malinowska, Elżbieta Katarzyna Jagusztyn-Krynicka
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13451 (2021)
The bacterial proteins of the Dsb family catalyze the formation of disulfide bridges between cysteine residues that stabilize protein structures and ensure their proper functioning. Here, we report the detailed analysis of the Dsb pathway of Campylob
Externí odkaz:
https://doaj.org/article/547c04ddddb8441fb0979aae7e45e095
Autor:
Katarzyna Kuncewicz, Claire Battin, Adam Sieradzan, Agnieszka Karczyńska, Marta Orlikowska, Anna Wardowska, Michał Pikuła, Peter Steinberger, Sylwia Rodziewicz-Motowidło, Marta Spodzieja
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8876 (2020)
One of the major current trends in cancer immunotherapy is the blockade of immune checkpoint proteins that negatively regulate the immune response. This has been achieved through antibodies blocking PD-1/PD-L1 and CTLA-4/CD80/CD86 interactions. Such
Externí odkaz:
https://doaj.org/article/6e9517922c3747c6bac83518fc6a62e5
Autor:
Marta Spodzieja, Katarzyna Kuncewicz, Adam Sieradzan, Agnieszka Karczyńska, Justyna Iwaszkiewicz, Valérie Cesson, Katarzyna Węgrzyn, Igor Zhukov, Martyna Maszota-Zieleniak, Olivier Michielin, Daniel E. Speiser, Vincent Zoete, Laurent Derré, Sylwia Rodziewicz-Motowidło
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 636 (2020)
Immune checkpoints are crucial in the maintenance of antitumor immune responses. The activation or blockade of immune checkpoints is dependent on the interactions between receptors and ligands; such interactions can provide inhibitory or stimulatory
Externí odkaz:
https://doaj.org/article/98637b024d7447fc829829c631ab6ec8
Autor:
Marta Spodzieja, Sławomir Lach, Justyna Iwaszkiewicz, Valérie Cesson, Katarzyna Kalejta, Daniel Olive, Olivier Michielin, Daniel E Speiser, Vincent Zoete, Laurent Derré, Sylwia Rodziewicz-Motowidło
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179201 (2017)
Antibody based immune-checkpoint blockade therapy is a major breakthrough in oncology, leading to clinical benefit for cancer patients. Among the growing family of inhibitory receptors, the B and T lymphocyte attenuator (BTLA), which interacts with h
Externí odkaz:
https://doaj.org/article/0046835261884b61849fa0574be8c961
Autor:
Magdalena Bojko, Katarzyna Węgrzyn, Emilia Sikorska, Mikołaj Kocikowski, Maciej Parys, Claire Battin, Peter Steinberger, Małgorzata M. Kogut, Michał Winnicki, Adam K. Sieradzan, Marta Spodzieja, Sylwia Rodziewicz-Motowidło
Publikováno v:
Bojko, M, Węgrzyn, K, Sikorska, E, Kocikowski, M, Parys, M, Battin, C, Steinberger, P, Kogut, M M, Winnicki, M, Sieradzan, A K, Spodzieja, M & Rodziewicz-Motowidło, S 2022, ' Design, synthesis and biological evaluation of PD-1 derived peptides as inhibitors of PD-1/PD-L1 complex formation for cancer therapy ', Bioorganic Chemistry, vol. 128, 106047, pp. 1-15 . https://doi.org/10.1016/j.bioorg.2022.106047
Over the past few years, many molecules such as monoclonal antibodies, affibodies, nanobodies, and small compounds have been designed and tested as inhibitors of PD-1/PD-L1 complex formation. Some of them have been successfully implemented into clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9790c9134f309a5f8bd988d48eb72b6f
https://doi.org/10.1016/j.bioorg.2022.106047
https://doi.org/10.1016/j.bioorg.2022.106047