Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marta Soltesova-Prnova"'
Autor:
Monika Martiniakova, Veronika Kovacova, Vladimira Mondockova, Karol Svik, Piotr Londzin, Joanna Folwarczna, Marta Soltesova Prnova, Milan Stefek, Radoslav Omelka
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 628 (2023)
Cemtirestat, a bifunctional drug acting as an aldose reductase inhibitor with antioxidant ability, is considered a promising candidate for the treatment of diabetic neuropathy. Our study firstly examined the effects of prolonged cemtirestat treatment
Externí odkaz:
https://doaj.org/article/562fb352ee644edba4dc76e99de80d7a
Autor:
Lucia Kovacikova, Marta Soltesova Prnova, Magdalena Majekova, Andrej Bohac, Cimen Karasu, Milan Stefek
Publikováno v:
Molecules, Vol 26, Iss 10, p 2867 (2021)
Aldose reductase (AR, ALR2), the first enzyme of the polyol pathway, is implicated in the pathophysiology of diabetic complications. Aldose reductase inhibitors (ARIs) thus present a promising therapeutic approach to treat a wide array of diabetic co
Externí odkaz:
https://doaj.org/article/6c61c67ed6cc454da514cbd4def22db7
Autor:
Rudolf Dupak, Jana Hrnkova, Nikoleta Simonova, Jan Kovac, Eva Ivanisova, Anna Kalafova, Monika Schneidgenova, Marta Soltesova Prnova, Jan Brindza, Katarina Tokarova, Marcela Capcarova
Publikováno v:
Research in veterinary science. 152
Sea buckthorn (Hippophae rhamnoides L.) is described by various beneficial effects as it contains several bioactive substances characterized by antioxidant effects. These effects are closely related to the reduction of oxidative stress that is involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed2746a8dad136579cfc3132b3bf966
https://pubmed.ncbi.nlm.nih.gov/36063603
https://pubmed.ncbi.nlm.nih.gov/36063603
Autor:
Edgar Rangel-López, Zubeyir Elmazoglu, Çimen Karasu, Abel Santamaría, Milan Stefek, Asli F. Ceylan, Michael Aschner, Marta Soltesova Prnova
Publikováno v:
Neurotoxicity Research. 39:588-597
Aldose reductase (AR) catalyzes the conversion of glucose to sorbitol in a NADPH-dependent reaction, thereby increasing the production of reactive oxygen species (ROS). Since AR activation is linked to redox dysregulation and cell damage in neurodege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58ac3d744148ef1e39170d54334aa7b
https://doi.org/10.1007/s12640-021-00349-7
https://doi.org/10.1007/s12640-021-00349-7
Autor:
Marta Soltesova-Prnova, Lukas Slovak, Monika Martiniakova, Juraj Payer, Radoslav Omelka, Veronika Kovacova, Karol Svik, Ingrid Oppenbergerova, Martina Babikova
Publikováno v:
Journal of Animal Physiology and Animal Nutrition. 105:336-344
The purpose of this study was to investigate the impact of eggshell calcium (Biomin H® dietary supplement) and its combinations with alfacalcidol (1α-hydroxyvitamin D3 ) and menaquinone-7 (vitamin K2 ) on ovariectomy-induced bone loss in rats. Adul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dce4828c4e2816614c67d2990304fd21
https://doi.org/10.1111/jpn.13458
https://doi.org/10.1111/jpn.13458
Autor:
Martin, Kratky, Peter, Sramel, Pavol, Bodo, Marta Soltesova, Prnova, Lucia, Kovacikova, Magdalena, Majekova, Jarmila, Vinsova, Milan, Stefek
Publikováno v:
European Journal of Medicinal Chemistry. 246:114922
Aldose reductase, the first enzyme of the polyol pathway represents a key drug target in therapy of diabetic complications. In this study a series of six novel rhodanine based inhibitors of aldose reductase was designed, synthesized, and tested for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be01c5a45bb563154dd64e33c0a2744a
https://doi.org/10.1016/j.ejmech.2022.114922
https://doi.org/10.1016/j.ejmech.2022.114922
Autor:
Lukas Slovak, Marianna Schwarzova, Marta Soltesova Prnova, Marcela Capcarova, Ján Brindza, Monika Schneidgenová, Anton Kováčik, Anna Kalafova, Karol Svik, Peter Kisska
Publikováno v:
Biologia. 75:705-711
Bee products are used in therapy of various diseases many years. As diabetes mellitus type 2 (DM2T) became a pandemic disease the searching for its treatment is necessary. In the literature there is evidence about beneficial properties of bee product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faeedadac96a53aa42b0777a9672ebd6
https://doi.org/10.2478/s11756-019-00337-5
https://doi.org/10.2478/s11756-019-00337-5
Autor:
Çimen Karasu, Karol Svik, Lucia Kovacikova, Štefan Bezek, Marta Soltesova Prnova, Milan Stefek
Publikováno v:
Neurochemical Research. 44:1056-1064
Peripheral neuropathy is the most prevalent chronic complication of diabetes mellitus. Good glycemic control can delay the appearance of neuropathic symptoms in diabetic patients but it is not sufficient to prevent or cure the disease. Therefore ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de378e707975542044d988da748519b6
https://doi.org/10.1007/s11064-019-02736-1
https://doi.org/10.1007/s11064-019-02736-1
Autor:
Sabina Yasmin, Dominika Halakova, Venkatesan Jayaprakash, Susanta Kumar Mondal, Marta Soltesova Prnova, Gayathri Dasararaju, Orlando Acevedo, Deepak Shilkar, Abhishek Thakur, Mohd Usman Mohd Siddique, Lucia Kovacikova, Velmurugan Devadasan, Milan Stefek
Publikováno v:
European journal of medicinal chemistry. 223
In search of dually active PPAR-modulators/aldose reductase (ALR2) inhibitors, 16 benzylidene thiazolidinedione derivatives, previously reported as partial PPARγ agonists, together with additional 18 structural congeners, were studied for aldose red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7289f1e075262178b585b0a198de005a
https://pubmed.ncbi.nlm.nih.gov/34175538
https://pubmed.ncbi.nlm.nih.gov/34175538
Autor:
Gilles Hanquet, Gabriela Addová, Matúš Hlaváč, Marta Soltesova Prnova, Milan Stefek, Lucia Kovacikova, Andrej Boháč
Publikováno v:
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2020
Bioorganic and Medicinal Chemistry, Elsevier, 2021, 29, pp.115885. ⟨10.1016/j.bmc.2020.115885⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2020
Bioorganic and Medicinal Chemistry, Elsevier, 2021, 29, pp.115885. ⟨10.1016/j.bmc.2020.115885⟩
International audience; Recently we have developed novel oxotriazinoindole inhibitors (OTIs) of aldose reductase (ALR2), characterized by high efficacy and selectivity. Herein we describe novel OTI derivatives design of which is based on implementati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9864da0d8d175b47891ee35ec8f429
https://hal.archives-ouvertes.fr/hal-03070904/document
https://hal.archives-ouvertes.fr/hal-03070904/document
