Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial

Autor: Alberto M Borobia, Antonio J Carcas, Mayte Pérez-Olmeda, Luis Castaño, María Jesús Bertran, Javier García-Pérez, Magdalena Campins, Antonio Portolés, María González-Pérez, María Teresa García Morales, Eunate Arana-Arri, Marta Aldea, Francisco Díez-Fuertes, Inmaculada Fuentes, Ana Ascaso, David Lora, Natale Imaz-Ayo, Lourdes E Barón-Mira, Antonia Agustí, Carla Pérez-Ingidua, Agustín Gómez de la Cámara, José Ramón Arribas, Jordi Ochando, José Alcamí, Cristóbal Belda-Iniesta, Jesús Frías, Lucía Martínez de Soto, Amelia Rodríguez Mariblanca, Lucía Díaz García, Elena Ramírez García, Enrique Seco Meseguer, Stefan Mark Stewart Balbás, Alicia Marín Candón, Irene García García, Mikel Urroz Elizalde, Jaime Monserrat Villatoro, Paula de la Rosa, Marta Sanz García, Cristina López Crespo, Vega Mauleón Martínez, Raquel de Madariaga Castell, Laura Vitón Vara, Julio García Rodríguez, Antonio Buño, Eduardo López Granados, Carmen Cámara, Esther Rey Cuevas, Pilar Ayllon García, María Jiménez González, Victoria Hernández Rubio, Paloma Moraga Alapont, Amparo Sánchez, Rocío Prieto, Silvia Llorente Gómez, Cristina Miragall Roig, Marina Aparicio Marlasca, Fernando de la Calle, Marta Arsuaga, Blanca Duque, Susana Meijide, Aitor García de Vicuña, Ana Santorcuato, Iraide Expósito, Sara de Benito, Joseba Andia, Cristina Castillo, Esther Irurzun, Jesús Camino, Mikel Temprano, Josune Goikoetxea, Alazne Bustinza, Maialen Larrea, Mikel Gallego, Dolores García-Vázquez, Ana Belén de la Hoz, Gustavo Pérez-Nanclares, Estíbaliz Pérez-Guzmán, Eneko Idoyaga, Adriana Lamela, Jesús Oteo, María Castillo de la Osa, Lourdes Hernández Gutiérrez, María Elena Andrés Galván, Esther Calonge, Mercedes Bermejo, Erick Humberto de la Torre-Tarazona, Almudena Cascajero, Giovanni Fedele, Concepción Perea, Isabel Cervera, Irene Bodega-Mayor, María Montes-Casado, Pilar Portolés, Jana Baranda, Laura Granés, Sulayman Lazaar, Sara Herranz, María Eugènia Mellado, Marta Tortajada, Montserrat Malet, Sebastiana Quesada, Anna Vilella, Anna Llupià, Victoria Olivé, Antoni Trilla, Begoña Gómez, Elisenda González, Sheila Romero, Francisco Javier Gámez, Cristina Casals, Laura Burunat, Juan José Castelló, Patricia Fernández, Josep Lluís Bedini, Jordi Vila, Carla Aguilar, Carmen Altadill, Lluis Armadans, Blanca Borras-Bermejo, Julia Calonge, Lina Camacho, Anna Feliu, Gisela Gili, Cesar Llorente, Xavier Martínez-Gómez, Susana Otero-Romero, Esther Palacio, Oleguer Parés, Laia Pinós, Aitana Plaza, Judit Riera-Arnau, José Angel Rodrigo-Pendás, Carla Sans, José Santos, Gloria Torres, Margarita Torrens, Sonia Uriona, Elena Ballarin Alins, Eulàlia Pérez Esquirol, Lourdes Vendrell Bosch, Leonor Laredo Velasco, Diana Uribe López, Esperanza González Rojano, Manuel Sánchez-Craviotto, Ana Belén Rivas Paterna, Teresa Iglesias Hernán-Gómez, Natalia Rodríguez Galán, José Antonio Gil Marín, Verónica Álvarez-Morales, Ana Belén Navalpotro, M Dolores Jiménez-Santamaría, M Carmen Cardós, Elena Hermoso, Mar García-Arenillas, Natalia Pérez Macías, Alexandra Domingo Fernández, Amanda López Picado, Jorge Mario Quiñones, Nicoletta Deidda, Ana García-Franco, José María Torvisco

Publikováno v: Lancet (London, England)
The Lancet

Background To date, no immunological data on COVID-19 heterologous vaccination schedules in humans have been reported. We assessed the immunogenicity and reactogenicity of BNT162b2 (Comirnaty, BioNTech, Mainz, Germany) administered as second dose in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c4faf65d198075b538d649718d0527
https://pubmed.ncbi.nlm.nih.gov/34724407

Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.

Autor: Sandra Blanco, Marta Sanz-García, Claudio R Santos, Pedro A Lazo

Publikováno v: PLoS ONE, Vol 3, Iss 2, p e1660 (2008)

BACKGROUND: Cellular biological responses to specific stimulation are determined by a balance among signaling pathways. Protein interactions are likely to modulate these pathways. Vaccinia-related kinase-2 (VRK2) is a novel human kinase that can modu

Externí odkaz: https://doaj.org/article/b2e0bfb1354248d0a0632474520c5ac3

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response

Autor: Marcella Salzano, Marta Sanz-García, Marta Vázquez-Cedeira, Sandra Blanco, Isabel F. Fernández, Pedro A. Lazo, Alberto Valbuena

Publikováno v: Oncotarget
Digital.CSIC. Repositorio Institucional del CSIC
instname

This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Vaccinia-related kinase 1 (VRK1) belongs to a group of sixteen kinases associated to a poorer prognosis in human breast carcinomas, particula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f2a473ad10a7578661df6c10b716f2
http://europepmc.org/articles/PMC4039124

Plk3 Interacts with and Specifically Phosphorylates VRK1 in Ser342, a Downstream Target in a Pathway That Induces Golgi Fragmentation

Autor: Inmaculada Lopez-Sanchez, Marta Sanz-García, Pedro A. Lazo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Golgi fragmentation is a process that is necessary to allow its redistribution into daughter cells during mitosis, a process controlled by serine-threonine kinases. This Golgi fragmentation is activated by MEK1 and Plk3. Plk3 is a kinase that is a do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12544ea904ab9ffac3c3dbcb0717efa7
https://doi.org/10.1128/mcb.01341-08

VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle

Autor: Ephrat Levy-Lahad, Paul Renbaum, Lara Cantarero, Marta Sanz-García, Pedro A. Lazo, Hadar Vinograd-Byk

Publikováno v: Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname

Cajal bodies (CBs) are nuclear organelles associated with ribonucleoprotein functions and RNA maturation. CBs are assembled on coilin, its main scaffold protein, in a cell cycle dependent manner. The Ser-Thr VRK1 (vaccinia-related kinase 1) kinase, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28417fbd36cc885d761c9f1ded188e59
https://pubmed.ncbi.nlm.nih.gov/26068304