Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Marta Rodriguez-Garcia"'
Autor:
Siddharth Parthasarathy, Laura Moreno de Lara, Francisco J. Carrillo-Salinas, Alexandra Werner, Anna Borchers, Vidya Iyer, Alison Vogell, Jared M. Fortier, Charles R. Wira, Marta Rodriguez-Garcia
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Dendritic cells (DCs) play critical roles in HIV pathogenesis and require further investigation in the female genital tract, a main portal of entry for HIV infection. Here we characterized genital DC populations at the single cell level and how DC su
Externí odkaz:
https://doaj.org/article/45d3bed69bdf4046bcf04ea465e5eeee
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Since CD4+ T cells are essential for regulating adaptive immune responses and for long lasting mucosal protection, changes in CD4+ T cell numbers and function are likely to affect protective immunity. What remains unclear is whether CD4+ T cell compo
Externí odkaz:
https://doaj.org/article/d5ec72daeb384a47b9b3b5980534d739
Autor:
Siddharth Parthasarathy, Zheng Shen, Francisco J. Carrillo-Salinas, Vidya Iyer, Alison Vogell, Diego Illanes, Charles R. Wira, Marta Rodriguez-Garcia
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Background Immune function in the genital mucosa balances reproduction with protection against pathogens. As women age, genital infections, and gynecological cancer risk increase, however, the mechanisms that regulate cell-mediated immune pr
Externí odkaz:
https://doaj.org/article/d25da0d028f24592ae8c17ec49c50db6
Autor:
Laura Moreno de Lara, Alexandra Werner, Anna Borchers, Francisco J. Carrillo-Salinas, Wendelin Marmol, Siddharth Parthasarathy, Vidya Iyer, Alison Vogell, Diego Illanes, Ana C. Abadía-Molina, Christina Ochsenbauer, Charles R. Wira, Marta Rodriguez-Garcia
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Women acquire HIV through sexual transmission, with increasing incidence in women >50 years old. Identifying protective mechanisms in the female genital tract (FGT) is important to prevent HIV-acquisition in women as they age. Human genital and blood
Externí odkaz:
https://doaj.org/article/bcf0d77f0b8f4c719b221f359e90fbbe
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-16 (2022)
Abstract Background Regulation of endometrial (EM) CD8+ T cells, which provide protection through cell-mediated cytotoxicity, is essential for successful reproduction, and protection against sexually transmitted infections and potential tumors. We ha
Externí odkaz:
https://doaj.org/article/ad6695ba39ff40e998cc78d1e50cba18
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Mucosal integrity in the endometrium is essential for immune protection. Since breaches or injury to the epithelial barrier exposes underlying tissue and is hypothesized to increase infection risk, we determined whether endogenous progestero
Externí odkaz:
https://doaj.org/article/65ea56eff26841df98fc709e4c1582b2
Autor:
Francisco J. Carrillo-Salinas, Siddharth Parthasarathy, Laura Moreno de Lara, Anna Borchers, Christina Ochsenbauer, Alexander Panda, Marta Rodriguez-Garcia
Publikováno v:
Cells, Vol 11, Iss 16, p 2515 (2022)
Half of the people living with HIV are women. Younger women remain disproportionally affected in endemic areas, but infection rates in older women are rising worldwide. The vaginal microbiome influences genital inflammation and HIV infection risk. Mu
Externí odkaz:
https://doaj.org/article/85e930a9d929469abb9485076d729976
Autor:
Mickey V. Patel, Zheng Shen, Marta Rodriguez-Garcia, Edward J. Usherwood, Laura J. Tafe, Charles R. Wira
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Endometrial cancer is the most common gynecological cancer. To investigate how it suppresses host immune function, we isolated CD8+ T cells from endometrial endometroid carcinomas and adjacent non-cancerous endometrium and determined if the tumor env
Externí odkaz:
https://doaj.org/article/38b34eb8f1ec4b15ba123134b298b988
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The functional characterization and regulation of tissue resident and non-resident CD8+ T cells in the human female reproductive tract (FRT) as women age remains a gap in our knowledge. Here we characterized the cytotoxic activity and granular conten
Externí odkaz:
https://doaj.org/article/5a3742420dbd4b93b9218d5332877892
Autor:
Marta Rodriguez-Garcia
Publikováno v:
eLife, Vol 9 (2020)
Immune cells in the endometrium are targeted by HIV and re-programmed to allow them to survive and spread the virus throughout the body.
Externí odkaz:
https://doaj.org/article/c6a446a51a034fd689525c9af46ec9fd