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Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
Autor:
Noel P. Fusté, Rita Fernández-Hernández, Tània Cemeli, Cristina Mirantes, Neus Pedraza, Marta Rafel, Jordi Torres-Rosell, Neus Colomina, Francisco Ferrezuelo, Xavier Dolcet, Eloi Garí
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Previous studies suggest that Cyclin D1 may regulate cell adhesion and migration but the mechanisms underlying such regulation and the relevance to cancer development are unknown. Here, Fusté et al. show that Cyclin D1/Cdk4 phosphorylates paxillin a
Externí odkaz:
https://doaj.org/article/c0e1a19ad0024a3ea991a7fbf199db91
Autor:
Marta Rafel, Ramon Martí, Samuel Bru, Eva Quandt, Joan M. Martínez-Láinez, Bàrbara Samper-Martín, Josep Clotet, Eloi Garí, Sara Hernández-Ortega, Javier Jiménez, Javier Torres-Torronteras, Mariana P.C. Ribeiro
Publikováno v:
Repositorio Abierto de la UdL
Universitad de Lleida
Universitad de Lleida
Cells require extra amounts of dNTPs to repair DNA after damage. Polyphosphate (polyP) is an evolutionary conserved linear polymer of up to several hundred inorganic phosphate (Pi) residues that is involved in many functions, including Pi storage. In
Publikováno v:
Dermatologic Surgery. 41:677-684
BACKGROUND Constitutive activation of the Erk pathway can lead to oncogenic transformation. However, the Erk pathway is not activated in human basal cell carcinomas (BCCs); although in animal models, this seems to be important. OBJECTIVE To help unde
Publikováno v:
Journal of Biological Chemistry. 284:32980-32988
E47 is a basic helix-loop-helix transcription factor involved in neuronal differentiation and survival. We had previously shown that the basic helix-loop-helix protein E47 binds to E-box sequences within the promoter of the TrkB gene and activates it
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
Autor:
Marta Rafel, Neus Colomina, Cristina Mirantes, Xavier Dolcet, Eloi Garí, Rita Fernández-Hernández, Noel P. Fusté, Tània Cemeli, Jordi Torres-Rosell, Francisco Ferrezuelo, Neus Pedraza
Publikováno v:
Nature Communications
Repositorio Abierto de la UdL
Universitad de Lleida
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Repositorio Abierto de la UdL
Universitad de Lleida
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Cyclin D1 (Ccnd1) together with its binding partner Cdk4 act as a transcriptional regulator to control cell proliferation and migration, and abnormal Ccnd1·Cdk4 expression promotes tumour growth and metastasis. While different nuclear Ccnd1·Cdk4 ta
Autor:
Josep Manel Casanova, Rafael S. Aguayo, Rita M. H. Fernández, Verónica Sanmartín, Eloi Garí, Marta Rafel, Maria Santacana
Publikováno v:
European journal of dermatology : EJD. 23(5)
ejd.2013.2130 Auteur(s) : Rafael S. Aguayo1,3 raguayo@comll.cat rafalleida@hotmail.com, Marta Rafel1,2, Maria Santacana1, Rita MH. Fernandez1,2, Veronica Sanmartin4, Josep M. Casanova1,3,4, Eloi Gari1,2 1 Institut de Recerca Biomedica de Lleida, 2 De
Autor:
Rafael S. Aguayo, Eloi Garí, Marta Rafel, Josep Manel Casanova, Joaquim Egea, Rita Fernández-Hernández, Francisco Ferrezuelo, Noel P. Fusté
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
instname
The function of Cyclin D1 (CycD1) has been widely studied in the cell nucleus as a regulatory subunit of the cyclin-dependent kinases Cdk4/6 involved in the control of proliferation and development in mammals. CycD1 has been also localized in the cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed0034339de6143ef9028e7c8216354
https://europepmc.org/articles/PMC3841329/
https://europepmc.org/articles/PMC3841329/
Publikováno v:
Repositorio Abierto de la UdL
Universitad de Lleida
Recercat. Dipósit de la Recerca de Catalunya
instname
Universitad de Lleida
Recercat. Dipósit de la Recerca de Catalunya
instname
The regulation of mRNA transport is a fundamental process for cytoplasmic sorting of transcripts and spatially controlled translational derepression once properly localized. There is growing evidence that translation is locally modulated as a result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531a60d6a098d04849a5c7c28964ea16
https://hdl.handle.net/10459.1/48183
https://hdl.handle.net/10459.1/48183
Autor:
Pieter B. F. Ouwerkerk, Paul Christou, Marta Rafel, L.J.G. van Enckevort, Gaëtan Droc, Andy Pereira, Stefano Berri, Emmanuel Guiderdoni, Pere Cabot, Pietro Piffanelli, Annemarie H. Meijer, Raffaella Greco, Víctor M. González, Lucia Colombo, Teresa Capell, Enrico Pè, Berta Miro, Fabio Fornara, Pere Puigdomènech, Ping Lan, Cyril Gagneur, Christele Weber
Publikováno v:
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Plant Molecular Biology
Plant Molecular Biology, Springer Verlag (Germany), 2005, 59 (1), pp.99-110. ⟨10.1007/s11103-005-8532-6⟩
Plant Molecular Biology, 59(1), 99-110
Plant Molecular Biology 59 (2005) 1
Digital.CSIC. Repositorio Institucional del CSIC
instname
Consejo Superior de Investigaciones Científicas (CSIC)
Plant Molecular Biology
Plant Molecular Biology, Springer Verlag (Germany), 2005, 59 (1), pp.99-110. ⟨10.1007/s11103-005-8532-6⟩
Plant Molecular Biology, 59(1), 99-110
Plant Molecular Biology 59 (2005) 1
Digital.CSIC. Repositorio Institucional del CSIC
instname
A collection of 1373 unique flanking sequence tags (FSTs), generated from Ac/Ds and Ac transposon lines for reverse genetics studies, were produced in japonica and indica rice, respectively. The Ds and Ac FSTs together with the original T-DNAs were a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6d92768605a5d6de0b618db0bf4148