Metabolic Modelling as a Framework for Metabolomics Data Integration and Analysis

Autor: Svetlana Volkova, Marta R. A. Matos, Matthias Mattanovich, Igor Marín de Mas

Publikováno v: Metabolites, Vol 10, Iss 8, p 303 (2020)

Metabolic networks are regulated to ensure the dynamic adaptation of biochemical reaction fluxes to maintain cell homeostasis and optimal metabolic fitness in response to endogenous and exogenous perturbations. To this end, metabolism is tightly cont

Externí odkaz: https://doaj.org/article/4c6d3d77cdc04195b5d56e63537a7731

Model-guided dynamic control of essential metabolic nodes boosts acetyl-coenzyme A-dependent bioproduction in rewired Pseudomonas putida

Autor: Mariela P. Mezzina, Marta R. A. Matos, Ekaterina Kozaeva, Lars K. Nielsen, Daniel C. Volke, Svetlana Volkova, Pablo I. Nikel, Tune Wulff

Publikováno v: Kozaeva, E, Volkova, S, Matos, M R A, Mezzina, M P, Wulff, T, Volke, D C, Nielsen, L K & Nikel, P I 2021, ' Model-guided dynamic control of essential metabolic nodes boosts acetyl-coenzyme A–dependent bioproduction in rewired Pseudomonas putida ', Metabolic Engineering, vol. 67, pp. 373-386 . https://doi.org/10.1016/j.ymben.2021.07.014

Pseudomonas putida is evolutionarily endowed with features relevant for bioproduction, especially under harsh operating conditions. The rich metabolic versatility of this species, however, comes at the price of limited formation of acetyl-coenzyme A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922c8ef8764441e40554210ca107c868
https://pubmed.ncbi.nlm.nih.gov/34343699

Combined In-Cell NMR and Simulation Approach to Probe Redox-Dependent Pathway Control

Autor: Marta R. A. Matos, Pernille Rose Jensen, Nikolaus Sonnenschein, Sebastian Meier

Publikováno v: Analytical chemistry. 91(8)

Dynamic response of intracellular reaction cascades to changing environments is a hallmark of living systems. As metabolism is complex, mechanistic models have gained popularity for describing the dynamic response of cellular metabolism and for ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c2c106ccf9f6d82d5a59a15f230d53
https://pubmed.ncbi.nlm.nih.gov/30896922