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pro vyhledávání: '"Marta Rúbies Bedós"'
Autor:
Irineos Papakyriacou, Ginte Kutkaite, Marta Rúbies Bedós, Divya Nagarajan, Liam P. Alford, Michael P. Menden, Yumeng Mao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Immune checkpoint blockade therapy aims to activate the immune system to eliminate cancer cells. However, clinical benefits are only recorded in a subset of patients. Here, we leverage genome-wide CRISPR/Cas9 screens in a Tumor-Immune co-Cul
Externí odkaz:
https://doaj.org/article/b4b21ac099f0476298aa50b1eda1257e
Autor:
Gürcan Tunalı, Marta Rúbies Bedós, Divya Nagarajan, Patrik Fridh, Irineos Papakyriacou, Yumeng Mao
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
Inflammatory mediators released by cancer cells promote the induction of immune suppression and tolerance in myeloid cells. IL-1 receptor–associated kinase-3 (IRAK3) is a pseudokinase that inhibits IL-1/TLR signaling, but its role in patients treat
Externí odkaz:
https://doaj.org/article/051fd3097dde4c799d18a39953014f50