Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk

Autor: Ye Lu, Manuel Gentiluomo, Angelica Macauda, Domenica Gioffreda, Maria Gazouli, Maria C. Petrone, Dezső Kelemen, Laura Ginocchi, Luca Morelli, Konstantinos Papiris, William Greenhalf, Jakob R. Izbicki, Vytautas Kiudelis, Beatrice Mohelníková-Duchoňová, Bas Bueno-de-Mesquita, Pavel Vodicka, Hermann Brenner, Markus K. Diener, Raffaele Pezzilli, Audrius Ivanauskas, Roberto Salvia, Andrea Szentesi, Mateus Nóbrega Aoki, Balázs C. Németh, Cosimo Sperti, Krzysztof Jamroziak, Roger Chammas, Martin Oliverius, Livia Archibugi, Stefano Ermini, János Novák, Juozas Kupcinskas, Ondřej Strouhal, Pavel Souček, Giulia M. Cavestro, Anna C. Milanetto, Giuseppe Vanella, John P. Neoptolemos, George E. Theodoropoulos, Hanneke W. M. van Laarhoven, Andrea Mambrini, Stefania Moz, Zdenek Kala, Martin Loveček, Daniela Basso, Faik G. Uzunoglu, Thilo Hackert, Sabrina G. G. Testoni, Viktor Hlaváč, Angelo Andriulli, Maurizio Lucchesi, Francesca Tavano, Silvia Carrara, Péter Hegyi, Paolo G. Arcidiacono, Olivier R. Busch, Rita T. Lawlor, Marta Puzzono, Ugo Boggi, Feng Guo, Ewa Małecka-Panas, Gabriele Capurso, Stefano Landi, Renata Talar-Wojnarowska, Oliver Strobel, Xin Gao, Yogesh Vashist, Daniele Campa, Federico Canzian

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Although 21 pancreatic cancer susceptibility loci have been identified in individuals of European ancestry through genome-wide association studies (GWASs), much of the heritability of pancreatic cancer risk remains unidentified. A recessive genetic m

Externí odkaz: https://doaj.org/article/03eb0137b83d4b1689c42abdfe892baa

Genetic and non-genetic risk factors for early-onset pancreatic cancer

Autor: Ylenia Nodari, Manuel Gentiluomo, Beatrice Mohelnikova-Duchonova, Edita Kreivenaite, Anna Caterina Milanetto, Jurgita Skieceviciene, Stefano Landi, Rita T Lawlor, Maria Chiara Petrone, Paolo Giorgio Arcidiacono, Martin Lovecek, Maria Gazouli, Maarten F. Bijlsma, Luca Morelli, Vytautas Kiudelis, Matteo Tacelli, Dalila Lucíola Zanette, Pavel Soucek, Faik Uzunoglu, Rudolf Kaaks, Jakob Izbicki, Ugo Boggi, Raffaele Pezzilli, Andrea Mambrini, Claudio Pasquali, Hanneke W. van Laarhoven, Verena Katzke, Giulia Martina Cavestro, Cosimo Sperti, Martin Loos, Anna Latiano, Bálint Erőss, Martin Oliverius, Theron Johnson, Daniela Basso, John P. Neoptolemos, Mateus Nóbrega Aoki, William Greenhalf, Pavel Vodicka, Livia Archibugi, Giuseppe Vanella, Maurizio Lucchesi, Renata Talar-Wojnarowska, Krzysztof Jamroziak, Mohammed Al Saeedi, Casper H.J. van Eijck, Juozas Kupcinskas, Tamás Hussein, Marta Puzzono, Stefania Bunduc, Mara Götz, Silvia Carrara, Andrea Szentesi, Francesca Tavano, Stefania Moz, Péter Hegyi, Claudio Luchini, Gabriele Capurso, Francesco Perri, Stefano Ermini, George Theodoropoulos, Giovanni Capretti, Orazio Palmieri, Laura Ginocchi, Niccolò Furbetta, Federico Canzian, Daniele Campa

Publikováno v: Digestive and Liver Disease. Elsevier
Nodari, Y, Gentiluomo, M, Mohelnikova-Duchonova, B, Kreivenaite, E, Milanetto, A C, Skieceviciene, J, Landi, S, Lawlor, R T, Petrone, M C, Arcidiacono, P G, Lovecek, M, Gazouli, M, Bijlsma, M F, Morelli, L, Kiudelis, V, Tacelli, M, Zanette, D L, Soucek, P, Uzunoglu, F, Kaaks, R, Izbicki, J, Boggi, U, Pezzilli, R, Mambrini, A, Pasquali, C, van Laarhoven, H W, Katzke, V, Cavestro, G M, Sperti, C, Loos, M, Latiano, A, Erőss, B L, Oliverius, M, Johnson, T, Basso, D, Neoptolemos, J P, Aoki, M N B, Greenhalf, W, Vodicka, P, Archibugi, L, Vanella, G, Lucchesi, M, Talar-Wojnarowska, R, Jamroziak, K, Saeedi, M A, van Eijck, C H J, Kupcinskas, J, Hussein, T, Puzzono, M, Bunduc, S, Götz, M, Carrara, S, Szentesi, A, Tavano, F, Moz, S, Hegyi, P T, Luchini, C, Capurso, G, Perri, F, Ermini, S, Theodoropoulos, G, Capretti, G, Palmieri, O, Ginocchi, L, Furbetta, N, Canzian, F & Campa, D 2023, ' Genetic and non-genetic risk factors for early-onset pancreatic cancer ', Digestive and Liver Disease . https://doi.org/10.1016/j.dld.2023.02.023
Digestive and liver disease. Elsevier

Background: Early-onset pancreatic cancer (EOPC) represents 5–10% of all pancreatic ductal adenocarcinoma (PDAC) cases, and the etiology of this form is poorly understood. It is not clear if established PDAC risk factors have the same relevance for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908b302f31600ad0c324d0be7a47532d
https://pure.eur.nl/en/publications/a96c0fc0-eb08-405f-bf2a-f59d50640a72

The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer

Autor: Daniele Campa, Manuel Gentiluomo, Angelika Stein, Mateus Nóbrega Aoki, Martin Oliverius, Ludmila Vodičková, Krzysztof Jamroziak, George Theodoropoulos, Claudio Pasquali, William Greenhalf, Paolo Giorgio Arcidiacono, Faik Uzunoglu, Raffaele Pezzilli, Claudio Luchini, Marta Puzzono, Martin Loos, Matteo Giaccherini, Verena Katzke, Andrea Mambrini, Edita Kiudeliene, Kauffmann Emanuele Federico, Julia Johansen, Tamás Hussein, Beatrice Mohelnikova-Duchonova, Casper H.J. van Eijck, Hermann Brenner, Riccardo Farinella, Juan Sainz Pérez, Martin Lovecek, Markus W. Büchler, Viktor Hlavac, Jakob R. Izbicki, Thilo Hackert, Roger Chammas, Alessandro Zerbi, Rita Lawlor, Alessio Felici, Mara Götz, Gabriele Capurso, Laura Ginocchi, Maria Gazouli, Juozas Kupcinskas, Giulia Martina Cavestro, Pavel Vodicka, Stefania Moz, John P. Neoptolemos, Lumir Kunovsky, Stig E. Bojesen, Silvia Carrara, Domenica Gioffreda, Egidijus Morkunas, Olga Abian, Stefania Bunduc, Daniela Basso, Ugo Boggi, Barbara Wlodarczyk, Andrea Szentesi, Giuseppe Vanella, Inna Chen, Maarten F. Bijlsma, Vytautas Kiudelis, Stefano Landi, Ben Schöttker, Chiara Corradi, Nathalia Giese, Rudolf Kaaks, Giulia Peduzzi, Péter Hegyi, Luca Morelli, Niccolò Furbetta, Pavel Soucek, Anna Latiano, Renata Talar-Wojnarowska, Sidsel C. Lindgaard, Frederike Dijk, Anna Caterina Milanetto, Francesca Tavano, Klara Cervena, Bálint Erőss, Sabrina G. Testoni, Judith H.E. Verhagen-Oldenampsen, Ewa Małecka-Wojciesko, Eithne Costello, Roberto Salvia, Evaristo Maiello, Stefano Ermini, Cosimo Sperti, Bernd Holleczek, Francesco Perri, Jurgita Skieceviciene, Livia Archibugi, Maurizio Lucchesi, Cosmeri Rizzato, Federico Canzian

Publikováno v: Critical reviews in oncology/hematology
Campa, D, Gentiluomo, M, Stein, A, Aoki, M N B, Oliverius, M, Vodičková, L, Jamroziak, K, Theodoropoulos, G, Pasquali, C, Greenhalf, W, Arcidiacono, P G, Uzunoglu, F, Pezzilli, R, Luchini, C, Puzzono, M, Loos, M, Giaccherini, M, Katzke, V, Mambrini, A, Kiudeliene, E, Federico, K E, Johansen, J, Hussein, T, Mohelnikova-Duchonova, B, van Eijck, C H J, Brenner, H, Farinella, R, Pérez, J S, Lovecek, M, Büchler, M W, Hlavac, V, Izbicki, J R, Hackert, T, Chammas, R, Zerbi, A, Lawlor, R, Felici, A, Götz, M, Capurso, G, Ginocchi, L, Gazouli, M, Kupcinskas, J, Cavestro, G M, Vodicka, P, Moz, S, Neoptolemos, J P, Kunovsky, L, Bojesen, S E, Carrara, S, Gioffreda, D, Morkunas, E, Abian, O, Bunduc, S, Basso, D, Boggi, U, Wlodarczyk, B, Szentesi, A, Vanella, G, Chen, I, Bijlsma, M F, Kiudelis, V, Landi, S, Schöttker, B, Corradi, C, Giese, N, Kaaks, R, Peduzzi, G, Hegyi, P T, Morelli, L, Furbetta, N, Soucek, P, Latiano, A, Talar-Wojnarowska, R, Lindgaard, S C, Dijk, F, Milanetto, A C, Tavano, F, Cervena, K, Erőss, B L, Testoni, S G, Verhagen-Oldenampsen, J H E, Małecka-Wojciesko, E, Costello, E, Salvia, R, Maiello, E, Ermini, S, Sperti, C, Holleczek, B, Perri, F, Skieceviciene, J, Archibugi, L, Lucchesi, M, Rizzato, C & Canzian, F 2023, ' The PANcreatic Disease ReseArch (PANDoRA) consortium : Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer ', Critical Reviews in Oncology/Hematology, vol. 186, 104020 . https://doi.org/10.1016/j.critrevonc.2023.104020

Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e2b865a80bd50161d13cfdbcf249c7
https://is.muni.cz/publication/2297219

Early Diagnosis of Colorectal Cancer by Biannual Fecal Immunochemical Tests: Is That Your Final Answer?

Autor: Alessandro, Mannucci, Marta, Puzzono, Silvio, Danese

Publikováno v: Gastroenterology. 162:2102-2104

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c690e2096251eb4e20a29135b90fe8
https://doi.org/10.1053/j.gastro.2022.01.036

Low-frequency of RABL3 pathogenetic variants in hereditary and familial pancreatic cancer

Autor: Stefano Crippa, Marta Puzzono, Giulia Martina Cavestro, Massimo Falconi, Ettore Zapparoli, Raffaella Alessia Zuppardo

Publikováno v: Digestive and Liver Disease. 53:519-521

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4712a30f74551c22af82b58c6416111
https://doi.org/10.1016/j.dld.2020.11.024