Výsledky vyhledávání - "Marta Pajares"

Akademický článek

Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas

Autor: Maribel Escoll, Diego Lastra, Marta Pajares, Natalia Robledinos-Antón, Ana I. Rojo, Raquel Fernández-Ginés, Marta Mendiola, Virginia Martínez-Marín, Isabel Esteban, Pilar López-Larrubia, Ricardo Gargini, Antonio Cuadrado

Publikováno v: Redox Biology, Vol 30, Iss , Pp - (2020)

Transcription factor NRF2 orchestrates a cellular defense against oxidative stress and, so far, has been involved in tumor progression by providing a metabolic adaptation to tumorigenic demands and resistance to chemotherapeutics. In this study, we d

Externí odkaz: https://doaj.org/article/b8990445efe3436cb0fdd0576778f576

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Akademický článek

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy

Autor: Ana I. Rojo, Marta Pajares, Angel J. García-Yagüe, Izaskun Buendia, Fred Van Leuven, Masayuki Yamamoto, Manuela G. López, Antonio Cuadrado

Publikováno v: Redox Biology, Vol 18, Iss , Pp 173-180 (2018)

Chronic neuroinflammation is a hallmark of the onset and progression of brain proteinopathies such as Alzheimer disease (AD) and it is suspected to participate in the neurodegenerative process. Transcription factor NRF2, a master regulator of redox h

Externí odkaz: https://doaj.org/article/b2146730596b411ea0a1cdc33d1d8c9a

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Akademický článek

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

Autor: Ana I. Rojo, Marta Pajares, Patricia Rada, Angel Nuñez, Alejo J. Nevado-Holgado, Richard Killik, Fred Van Leuven, Elena Ribe, Simon Lovestone, Masayuki Yamamoto, Antonio Cuadrado

Publikováno v: Redox Biology, Vol 13, Iss C, Pp 444-451 (2017)

Failure to translate successful neuroprotective preclinical data to a clinical setting in Alzheimer's disease (AD) indicates that amyloidopathy and tauopathy alone provide an incomplete view of disease. We have tested here the relevance of additional

Externí odkaz: https://doaj.org/article/d68186949f744c309d22a00c4b5bae87

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Akademický článek

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

Autor: Marta Pajares, Antonio Cuadrado, Ana I. Rojo

Publikováno v: Redox Biology, Vol 11, Iss , Pp 543-553 (2017)

Neurodegenerative diseases are linked to the accumulation of specific protein aggregates, suggesting an intimate connection between injured brain and loss of proteostasis. Proteostasis refers to all the processes by which cells control the abundance

Externí odkaz: https://doaj.org/article/1d7c1d4f32be4a5bae6e68268d2d6c58

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Akademický článek

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

Autor: Marta Pajares, Ana I. Rojo, Gina Manda, Lisardo Boscá, Antonio Cuadrado

Publikováno v: Cells, Vol 9, Iss 7, p 1687 (2020)

Parkinson’s disease (PD) is a common neurodegenerative disorder primarily characterized by the death of dopaminergic neurons that project from the substantia nigra pars compacta. Although the molecular bases for PD development are still little defi

Externí odkaz: https://doaj.org/article/9a146ba23fd14520bb0dbf2b6ea81645

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Akademický článek

Repurposing Zileuton as a Depression Drug Using an AI and In Vitro Approach

Autor: Norwin Kubick, Marta Pajares, Ioana Enache, Gina Manda, Michel-Edwar Mickael

Publikováno v: Molecules, Vol 25, Iss 9, p 2155 (2020)

Repurposing drugs to target M1 macrophages inflammatory response in depression constitutes a bright alternative for commonly used antidepressants. Depression is a significant type of mood disorder, where patients suffer from pathological disturbances

Externí odkaz: https://doaj.org/article/4b79124037c24bd985fab3685f457d5d

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