Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Marta Paez‐Ribes"'
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp 1-19 (2019)
Abstract Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest occurring in response to damage and stress and is consid
Externí odkaz:
https://doaj.org/article/f1552ee743934e8493ca70abe9e11fb1
Autor:
Daniel Muñoz‐Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano‐Torres, Marta Paez‐Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz‐Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez‐Máñez, Manuel Serrano
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 9, Pp 1-18 (2018)
Abstract Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β‐galactosidase activity of senescent
Externí odkaz:
https://doaj.org/article/d67df62499c14123a2c81e830cc433e4
Autor:
Michela Borghesan, Juan Fafián-Labora, Olga Eleftheriadou, Paula Carpintero-Fernández, Marta Paez-Ribes, Gema Vizcay-Barrena, Avital Swisa, Dror Kolodkin-Gal, Pilar Ximénez-Embún, Robert Lowe, Belen Martín-Martín, Hector Peinado, Javier Muñoz, Roland A. Fleck, Yuval Dor, Ittai Ben-Porath, Anna Vossenkamper, Daniel Muñoz-Espin, Ana O’Loghlen
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3956-3971.e6 (2019)
Summary: Senescence is a cellular phenotype present in health and disease, characterized by a stable cell-cycle arrest and an inflammatory response called senescence-associated secretory phenotype (SASP). The SASP is important in influencing the beha
Externí odkaz:
https://doaj.org/article/b729ed53c3154141a7268dbbac8c71b2
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158034 (2016)
Several approaches are being evaluated to improve the historically limited value of studying transplanted primary tumors derived by injection of cells from established cell lines for predicting subsequent cancer therapy outcomes in patients and clini
Externí odkaz:
https://doaj.org/article/ba1c2a9cd7224106be427e0af88c80fd
Autor:
Robert S. Kerbel, Urban Emmenegger, Steven R. Pirie-Shepherd, Christina R. Lee, Marta Paez-Ribes, Annabelle Chow, Ping Xu, Shan Man, Florence T.H. Wu
Supplemental Figure S1. Primary LM2-4luc16 breast tumors treated with CVX-2000, vehicle only, sunitinib, CVX-060, or sunitinib plus CVX-060. Supplemental Figure S2. Direct inhibitory effects of sunitinib and regorafenib on endothelial Tie2 vs. VEGFR2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50965c341b66780611b413169ae8ef80
https://doi.org/10.1158/0008-5472.22413203
https://doi.org/10.1158/0008-5472.22413203
Supplemental figures 1-3. Supplemental figure 1. Addition of chemotherapy enhances tumor growth inhibition and blocks local tumor invasion. Supplemental figure 2. Cyclophosphamide, when added to antiangiogenic therapy, inhibits tumor growth and block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408eb968766487d25f5d45d07666610a
https://doi.org/10.1158/1078-0432.22459910
https://doi.org/10.1158/1078-0432.22459910
Autor:
Robert S. Kerbel, Urban Emmenegger, Steven R. Pirie-Shepherd, Christina R. Lee, Marta Paez-Ribes, Annabelle Chow, Ping Xu, Shan Man, Florence T.H. Wu
Supplemental Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d421541d9d62570585bc502b242b19
https://doi.org/10.1158/0008-5472.22413200.v1
https://doi.org/10.1158/0008-5472.22413200.v1
Purpose: To resolve a controversy involving the therapeutic impact of antiangiogenic drugs and particularly antibodies targeting the VEGF pathway, namely, a body of preclinical mouse therapy studies showing such drugs can promote invasion and/or dist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d09a431a527eb9071a82ae67474c7a
https://doi.org/10.1158/1078-0432.c.6524336.v1
https://doi.org/10.1158/1078-0432.c.6524336.v1
Autor:
Robert S. Kerbel, Urban Emmenegger, Steven R. Pirie-Shepherd, Christina R. Lee, Marta Paez-Ribes, Annabelle Chow, Ping Xu, Shan Man, Florence T.H. Wu
Antiangiogenic tyrosine kinase inhibitors (TKI) that target VEGF receptor-2 (VEGFR2) have not been effective as adjuvant treatments for micrometastatic disease in phase III clinical trials. Angiopoietin-2 (Ang2) is a proangiogenic and proinflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3586642fb245bbd1cf1ac36483fd2784
https://doi.org/10.1158/0008-5472.c.6508646.v1
https://doi.org/10.1158/0008-5472.c.6508646.v1
Autor:
Beatriz, Lozano-Torres, Juan F, Blandez, Irene, Galiana, José A, Lopez-Dominguez, Miguel, Rovira, Marta, Paez-Ribes, Estela, González-Gualda, Daniel, Muñoz-Espín, Manuel, Serrano, Félix, Sancenón, Ramón, Martínez-Máñez
Publikováno v:
Analytical Chemistry
Cellular senescence is a state of stable cell cycle arrest that can negatively affect the regenerative capacities of tissues and can contribute to inflammation and the progression of various aging-related diseases. Advances in the in vivo detection o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d8bc6a5add68290a66a8f0c3ee311a39
https://pubmed.ncbi.nlm.nih.gov/33502178
https://pubmed.ncbi.nlm.nih.gov/33502178