Výsledky vyhledávání - "Marta Orsenigo"

Unusual Myogenic and Melanocytic Differentiation of Soft Tissue pPNETs

Autor: Carlo Terenzio Paties, Antonella Aiello, Paola Collini, Palma Dileo, Marta Orsenigo, Marta Barisella, Silvana Pilotti

Publikováno v: American Journal of Surgical Pathology. 34:1002-1006

All of the members of the peripheral primitive neuroectodermal tumor family (Ewing sarcomas, neuroectodermal tumors of bone, peripheral neuroepitheliomas, and Askin tumors) have similar morphologic and immunophenotypical features (ie, the proliferati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999df531b2fe4e7c314c4fecf99bf8b8
https://doi.org/10.1097/pas.0b013e3181e03b81

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Polymorphisms of Metabolizing Enzymes and Susceptibility to Ethmoid Intestinal-type Adenocarcinoma in Professionally Exposed Patients

Autor: Giulio Cantù, Stefano Riccio, Sarah Colombo, Clara Millefanti, Marco A. Pierotti, Federica Perrone, Marta Orsenigo, Silvana Pilotti, Luigi Mariani, Elisa Pastore

Publikováno v: Translational Oncology. 2(2):84-88

Intestinal-type adenocarcinoma (ITAC) of ethmoid is a rare tumor associated with occupational exposure to wood and leather dusts. Polymorphisms in xenobiotic metabolizing enzymes play an important role in gene-environment interactions and may contrib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4a4f80ca9cef72a0f10b6bb5216281

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Response to Sunitinib Malate in Advanced Alveolar Soft Part Sarcoma

Autor: Sara Arisi Rota, Flavio Crippa, Silvia Brich, Paolo G. Casali, Andrea Marrari, Carlo Morosi, Marta Orsenigo, Elena Tamborini, Alessandro Gronchi, Silvana Pilotti, Silvia Stacchiotti, Marco A. Pierotti

Publikováno v: Clinical Cancer Research. 15:1096-1104

Purpose: Alveolar soft part sarcoma (ASPS) is a rare, chemoresistant soft tissue sarcoma. ASPS harbors the t(17-X) (p11.2;q25) translocation, resulting in the ASPACR1-TFE3 fusion protein, causing MET autophosphorylation and activation of downstream s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53130d4aa53492d0328e0fd54853b853
https://doi.org/10.1158/1078-0432.ccr-08-2050

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c-Kit/PDGFRA Gene Status Alterations Possibly Related to Primary Imatinib Resistance in Gastrointestinal Stromal Tumors

Autor: Marta Orsenigo, Francesca Miselli, Marco Fiore, Alessandro Gronchi, Silvana Pilotti, Antonino Carbone, Paola Casieri, M. Stefania Lagonigro, Elena Tamborini, Tiziana Negri, Paolo G. Casali, Rossella Bertulli, Marco A. Pierotti

Publikováno v: Clinical Cancer Research. 13:2369-2377

Purpose: To correlate morphologic changes with molecular, biochemical, and cytogenetic profiles in gastrointestinal stromal tumor (GIST) patients before and after imatinib treatment. Experimental Design: We investigated 132 tumor samples obtained fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711760e7d03fd1ecb06a0558d5c1b8dc
https://doi.org/10.1158/1078-0432.ccr-06-1745

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Receptor tyrosine kinase pathway analysis sheds light on similarities between clear-cell sarcoma and metastatic melanoma

Autor: Piero Picci, Marco Alberghini, Alessandro Gronchi, Silvana Pilotti, Valentina Mauro, Silvia Brich, Giuseppina F. Dusio, Marta Orsenigo, Marco A. Pierotti, Fabio Bozzi, Silvia Stacchiotti, Elena Conca, Giuseppe Pelosi, Tiziana Negri, Paolo G. Casali

To highlight possible similarities and differences in receptor tyrosine kinase (RTK) and downstream signalling activation profiles between clear-cell sarcomas (CCS) and metastatic melanomas (MM), frozen, and paired-matched fixed samples of six CCS wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55bcd7b9567f2262602fa892893997c9
https://hdl.handle.net/11368/2904184

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Fluorescence in situ hybridization analysis and immunophenotyping of c-Kit/PDGFRA and Bcl-2 expression in gastrointestinal stromal tumors

Autor: Marta, Orsenigo, Silvia, Brich, Carla, Riva, Elena, Conca, Rossella, Bertulli, Palma, Dileo, Alessandro, Gronchi, Paolo G, Casali, Marco A, Pierotti, Elena, Tamborini, Silvana, Pilotti

Publikováno v: Analytical and quantitative cytology and histology. 32(4)

To investigate c-Kit/PDGFRA genomic alterations, KIT-PDGFRA coexpression in gastrointestinal stromal tumors (GISTs) and the role of Bcl-2.We analyzed 70 primary tumors, 6 recurrences, 4 metastases and 1 recurrence plus metastasis, all molecularly cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c89186896f0fc8c71064c80cfdb1887c
https://pubmed.ncbi.nlm.nih.gov/21434524

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Chromosome band 17q21 in breast cancer: significant association between beclin 1 loss and HER2/NEU amplification

Autor: Manuela Gariboldi, Milvia Zambetti, James F. Reid, Silvana Pilotti, Tiziana Negri, Eva Tarantino, Marta Orsenigo, Marco A. Pierotti

Publikováno v: Genes, chromosomescancer. 49(10)

Treatment success of breast cancer patients with trastuzumab alone or in combination depends not only on HER2/NEU amplification but also on PTEN and PI3K status and efficient cell death programs. In this pilot study, we found a significant associatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7bf735d820c6ad1f28e4b9b633b488
https://pubmed.ncbi.nlm.nih.gov/21319263

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Receptor tyrosine kinase and downstream signalling analysis in diffuse malignant peritoneal mesothelioma

Autor: Marcello Deraco, Marta Orsenigo, Rossella Bertulli, Eva Tarantino, Claudia Bertan, Nadia Zaffaroni, Genny Jocollè, Antonello Domenico Cabras, Silvia Brich, Cinzia De Marco, Dario Baratti, Silvana Pilotti, Marco A. Pierotti, Federica Perrone, Marzia Pennati

Publikováno v: European journal of cancer (Oxford, England : 1990). 46(15)

Our aim was to assess the activation profile of EGFR, PDGFRB and PDGFRA receptor tyrosine kinases (RTK) and their downstream effectors in a series of cryopreserved diffuse malignant peritoneal mesothelioma (DMPM) surgical specimens to discover the ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762e3cf8f445eaffe1ebcfcdc50c5af6
https://pubmed.ncbi.nlm.nih.gov/20692828

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Analysis of receptor tyrosine kinases (RTKs) and downstream pathways in chordomas

Autor: Giacomo Manenti, Emanuela Virdis, Paolo G. Casali, Elena Tamborini, Tiziana Negri, Alessandro Gronchi, Silvia Brich, Marta Orsenigo, Silvia Stacchiotti, Silvana Pilotti, Elena Conca, Marco A. Pierotti

Publikováno v: Neuro-oncology. 12(8)

We have previously demonstrated that chordomas express activated platelet-derived growth factor receptor (PDGFRB) and that treatment with imatinib, which is capable of switching off the activation of various receptor tyrosine kinases (RTKs) including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e1f7cec744122c2add353a5c6581bc
https://pubmed.ncbi.nlm.nih.gov/20164240

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Treatment relevant target immunophenotyping of 139 salivary gland carcinomas (SGCs)

Autor: Marta Orsenigo, Paola Casieri, Cecilia Liberatoscioli, Lisa Licitra, Tiziana Negri, Cristiana Bergamini, Paolo Bossi, Marco Losa, Laura D. Locati, Rosa Gioia Calderone, Elena Tamborini, Pasquale Quattrone, Barbara Cortelazzi, Federica Perrone, G. Rinaldi, Micol Mela

Publikováno v: Oral oncology. 45(11)

Salivary gland carcinomas (SGCs) are rare tumors encompassing a wide spectrum of histologic/biologic entities. Standard non-surgical treatments are ineffective in case of advanced disease. Our aim was to analyze SGCs deregulation gene profiles that c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800f37cc62edeb39eb88930e61821f97
https://pubmed.ncbi.nlm.nih.gov/19574086

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