Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marta Novais"'
Autor:
Cecília Monteiro, Jaleh S. Mesgarzadeh, João Anselmo, Joana Fernandes, Marta Novais, Carla Rodrigues, David L. Powers, Evan T. Powers, Teresa Coelho, Jeffery W. Kelly
Publikováno v:
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
TTR aggregation causes hereditary transthyretin (TTR) polyneuropathy (ATTRv-PN) in individuals with destabilised TTR variants. ATTRv-PN can be treated with ligands that bind TTR and prevent aggregation. One such ligand, tafamidis, is widely approved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40e1ef030e12950e6c10b8f42c45520
https://pubmed.ncbi.nlm.nih.gov/36178172
https://pubmed.ncbi.nlm.nih.gov/36178172
Autor:
Messias, Gladistone Correia1, Rocha, Ana Marta Novais1, Santos, Beatriz Manuela Silva1, Botelho, Ana Marques1, Silva, Dhaísa Cristhina Alves1, Porto, Erika Santos1, dos Anjos, Marina Lima1, Sousa, Rayra Almeida1, Silva, Mara Viana1, da Rocha, Thainara Barros1, de Melo, Aracely Vieira1, Carneiro, Manoela Rios Trindade1, Aguiar, Nayonara Santana1, Santos, Patrícia Prado1, de Souza, Erika Pereira1, Cruz, Mariluze Peixoto1, Marques, Lucas Miranda1, Yatsuda, Regiane1, Rezende, Raquel Passos1,2, Romano, Carla Cristina1,2
Publikováno v:
European Journal of Nutrition. Apr2019, Vol. 58 Issue 3, p1137-1146. 10p. 3 Charts, 2 Graphs.
Autor:
Cecília Monteiro, Xin Jiang, Marta Novais, Richard Labaudinière, Jeffery W. Kelly, Teresa Coelho, Joel N. Buxbaum
Publikováno v:
Proc Natl Acad Sci U S A
The transthyretin (TTR) amyloidoses (ATTR) are progressive, degenerative diseases resulting from dissociation of the TTR tetramer to monomers, which subsequently misfold and aggregate, forming a spectrum of aggregate structures including oligomers an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746f1965f25148899da4e0ff2fbb2b09
https://doi.org/10.1073/pnas.2016072118
https://doi.org/10.1073/pnas.2016072118
Autor:
Marta Novais, Ana Martins da Silva, Jeffery W. Kelly, Cecília Monteiro, Jaleh Mesgarzadeh, Natália Ferreira, Teresa Coelho
Publikováno v:
Amyloid. 25:120-128
Hereditary transthyretin (TTR) amyloidosis associated with the TTRV30M (p.TTRV50M) mutation presents predominantly as an axonal polyneuropathy, with variable involvement of other organs. Serious central nervous system (CNS) and eye manifestations, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531f357b1f65d62c62c7dd9c26e37515
https://doi.org/10.1080/13506129.2018.1479249
https://doi.org/10.1080/13506129.2018.1479249
Autor:
Érika Pereira De Souza, Mariluze Peixoto Cruz, Raquel Passos Rezende, Ana Paula Trovatti Uetanabaro, Marina Lima dos Anjos, Thainara Barros da Rocha, Aracely Vieira de Melo, Dhaísa Cristhina Alves Silva, Mara Viana Silva, Regiane Yatsuda, Ana Marques Botelho, Beatriz Manuela Silva Santos, Gabriel Vinderola, Patrícia Prado Santos, Carla Cristina Romano, Nayonara Santana Aguiar, Gladistone Correia Messias, Erika Santos Porto, Manoela Rios Trindade Carneiro, Ana Marta Novais Rocha, Rayra Almeida Sousa, Lucas Miranda Marques
Purpose: Lactobacillus plantarum Lp62 is a lactic acid bacteria strain that has been isolated from cocoa beans and exhibited probiotic potential. The influence of oral administration of L. plantarum Lp62 on the growth of rat’s pups; on yield, cytok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682328f5e6e9c367a993b921b9a1d9dd
http://link.springer.com/10.1007/s00394-018-1628-y
http://link.springer.com/10.1007/s00394-018-1628-y
Autor:
Sunil M. Kurian, Terri Gelbart, Thomas Whisenant, Teresa Coelho, Jeffery W. Kelly, Marta Novais, Joel N. Buxbaum, Daniel R. Salomon
Publikováno v:
Theranostics
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
BACKGROUND: Early diagnosis of familial transthyretin (TTR) amyloid diseases remains challenging because of variable disease penetrance. Currently, patients must have an amyloid positive tissue biopsy to be eligible for disease-modifying therapies. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed713396af067ed98206beb8b35fabb
http://europepmc.org/articles/PMC4997237
http://europepmc.org/articles/PMC4997237
Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients
Autor:
Joseph D. Schonhoft, Cecília Monteiro, Christopher G. Parker, Lars Plate, Marta Novais, Benjamin F. Cravatt, Teresa Coelho, John L. Berk, Daniel Boland, John M. Kelly, Jeffery W. Kelly, Mathew S. Maurer, Evan T. Powers, Sergio Teruya, Yvonne S. Eisele, Stephen Helmke, Yoshiki Sekijima
Publikováno v:
Science Translational Medicine. 9
Increasing evidence supports the hypothesis that soluble misfolded protein assemblies contribute to the degeneration of post-mitotic tissue in amyloid diseases. However, there is a dearth of reliable non-antibody based probes for selectively detectin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f5b6521932ca3cd217b77e65c1ffce
https://doi.org/10.1126/scitranslmed.aam7621
https://doi.org/10.1126/scitranslmed.aam7621
Autor:
Irit Rappley, R. Luke Wiseman, Mathew S. Maurer, Teresa Coelho, Gregory M. Solis, Evan T. Powers, Marta Novais, Jeffery W. Kelly, Aleksandra Baranczak, Cecília Monteiro, Stephen Helmke
Publikováno v:
Biochemistry
The transthyretin (TTR) amyloidoses are a group of degenerative diseases caused by TTR aggregation, requiring rate-limiting tetramer dissociation. Kinetic stabilization of TTR, by preferential binding of a drug to the native tetramer over the dissoci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980fbd673f13c1080928504312f0caf5
https://doi.org/10.1021/bi500171j
https://doi.org/10.1021/bi500171j
Autor:
Elena Maria Ghibaudi, António Amorim, Luísa Azevedo, Gianpaolo Suriano, Raquel Seruca, Marta Novais, Barbara Boscolo
Publikováno v:
Human molecular genetics. 16(18)
Ornithine transcarbamylase deficiency (OTCD) is an X-linked inborn defect of metabolism of the urea cycle, which causes hyperamonemia. Mutations of the OTC gene have been recognized as the genetic cause underlying the OTC deficiency. The severity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b11b28445744e2ca2fdc48d125f0d5
https://pubmed.ncbi.nlm.nih.gov/17613537
https://pubmed.ncbi.nlm.nih.gov/17613537
Autor:
J. Correia, Carla Oliveira, Daniele Marrelli, F. Roviello, Luis Cirnes, Corrado Pedrazzani, G. Corso, Joana Paredes, Gianpaolo Suriano, Raquel Seruca, Marta Novais
Aim: Hereditary diffuse gastric cancer (HDGC) is a cancer susceptibility syndrome caused by E-cadherin germline mutations. One-third of these mutations are of the missense type, representing a burden in genetic counselling. A new germline missense mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91aa58282723394c9c78e080889dced
http://hdl.handle.net/11365/28588
http://hdl.handle.net/11365/28588