Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Marta Nevalainen"'
Autor:
Bin Ma, Claire M. Metrick, Chungang Gu, Marc Hoemberger, Bekim Bajrami, Eris Bame, Jiansheng Huang, Michael Mingueneau, Paramasivam Murugan, Marta Nevalainen, Joseph C. Santoro, Hao Tang, Ti Wang, Brian T. Hopkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 72:128856
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2269328ef74fb6f1cdf55f7c5dd90de
https://doi.org/10.1016/j.bmcl.2022.128856
https://doi.org/10.1016/j.bmcl.2022.128856
Autor:
Kristopher W King, Brenda Amaral, Eli Schuman, LaiYee Wong, Michael Rooney, Marta Nevalainen, Jun Feng, Paramasivam Murugan, Jayanth V. Chodaparambil, Thomas A. Patterson, Hannah Certo, Martin K Himmelbauer, Rab Gilfillan, Tamara Halkina, Sarah Lamore, J Howard Jones, Douglas Marcotte, Gregory M Dillon, Jaclyn L. Henderson, Thomas Hesson, P Rajesh Kumar, Edward Yin-Shiang Lin, Channa Bao, Felix Gonzalez-Lopez de Turiso, Joshua L Johnson, Michael Calhoun
Publikováno v:
Journal of medicinal chemistry. 64(9)
Structural analysis of the known NIK inhibitor 3 bound to the kinase domain of TTBK1 led to the design and synthesis of a novel class of azaindazole TTBK1 inhibitors exemplified by 8 (cell IC50: 571 nM). Systematic optimization of this series of anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24de7147f81434a735de9781d30290ec
https://pubmed.ncbi.nlm.nih.gov/33944571
https://pubmed.ncbi.nlm.nih.gov/33944571
Autor:
Huiming Zhang, Linda Lee, Sudeep Prajapati, Betty Chan, Kazunobu Kira, Mingde Shan, Laura Corson, Ming-Hong Hao, Kuo-Ming Wu, O'shea Morgan Welzel, Yoshiharu Mizui, Samantha Perino, John Wang, Eun Sun Park, Lisa A. Marcaurelle, Marta Nevalainen, Arai Kenzo, Guo-Zhu Zheng, Markus Warmuth, Lihua Yu, Atsushi Endo, Jason T. Lowe, Xiang Liu, Baudouin Gerard, Pete Smith, Tivitmahaisoon Parcharee, Craig Karr, Silvia Buonamici, Keaney Gregg F, Tuoping Luo
Publikováno v:
Organic Letters. 16:5560-5563
A total synthesis of the natural product 6-deoxypladienolide D (1) has been achieved. Two noteworthy attributes of the synthesis are (1) a late-stage allylic oxidation which proceeds with full chemo-, regio-, and diastereoselectivity and (2) the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60a255bfd7796bff2bb3d4c8b6a0b4b
https://doi.org/10.1021/ol502556c
https://doi.org/10.1021/ol502556c
Autor:
Matthew Campbell, Caroline N. Woodward, Jens Sydor, Alfredo C. Castro, James R. Porter, Margaret A. Read, Kerrie Faia, Kerry White, Martin R. Tremblay, Jill Cushing, Julian Adams, Lin-Chen Yu, Mark L. Behnke, Jennifer Hoyt, Vito J. Palombella, Karen McGovern, Somarajan J. Nair, Jeffrey K. Tong, Margit Hagel, Marta Nevalainen, Louis Grenier, Michael Foley
Publikováno v:
Journal of Medicinal Chemistry. 51:6646-6649
Herein is reported the synthesis of a novel class of hedgehog antagonists derived from cyclopamine. The acid sensitive D-ring of cyclopamine was homologated utilizing a sequence of chemoselective cyclopropanation and stereoselective acid-catalyzed re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d0752adc424ed0f2bb4f871b70a4f4
https://doi.org/10.1021/jm8008508
https://doi.org/10.1021/jm8008508
Autor:
Anthony Estrada, Brian Safina, Marta Nevalainen, Kyriacos C. Nicolaou, Sang Hyup Lee, Mark Zak
Publikováno v:
Journal of the American Chemical Society. 127:11176-11183
The completion of the total synthesis of thiostrepton (1) is described. The synthesis proceeded from key building blocks 2-5, which were assembled into a growing substrate that finally led to the target molecule. Thus, the dehydropiperidine peptide c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda1e7e17009f40255f01396b8a50a7a
https://doi.org/10.1021/ja052934z
https://doi.org/10.1021/ja052934z
Publikováno v:
Tetrahedron. 60:9199-9204
A new short strategy to prepare the spiroketal fragment of calyculins is presented. A novel Seyferth–Gilbert type homologation of hindered lactols to the corresponding alkynes has been achieved for the first time. The spirocyclization was achieved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08ce4cb56cd84ef622ebad513b2410ff
https://doi.org/10.1016/j.tet.2004.07.059
https://doi.org/10.1016/j.tet.2004.07.059
Autor:
Ari M. P. Koskinen, Marta Nevalainen
Publikováno v:
The Journal of Organic Chemistry. 67:1554-1560
The first total synthesis of (+/-)-nor-1,6-germacradien-5-ols is described. The synthetic route involves the RCM methodology for the ring formation and a selective 1,2 addition of MeLi to cyclodecenone. By altering the order of the last synthetic ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359d9426727ba09f3e0848c7c762d153
https://doi.org/10.1021/jo016110l
https://doi.org/10.1021/jo016110l
Autor:
Marta Nevalainen, Vesa Nevalainen
Publikováno v:
Tetrahedron: Asymmetry. 12:1771-1777
1,7,7-Trimethyl-3-(pyrid-2-ylmethyl)bicyclo[2.2.1]heptan-2-ol 4 and its 2-phenyl, 2-methyl and 2-butyl analogs 5 – 7 were synthesized, characterized and used as ligands for the addition of diethylzinc to benzaldehydes. Best results were attained wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6d2bb809b7c5cd2c54a94e8344a0986
https://doi.org/10.1016/s0957-4166(01)00295-6
https://doi.org/10.1016/s0957-4166(01)00295-6
Publikováno v:
The Journal of Organic Chemistry. 66:2061-2066
Fmoc-protected trans-4-methylproline was synthesized starting from D-serine. The chiral scaffold of serine in the form of olefinated Garner's aldehyde 3 was used to control the diastereoselective formation of the new stereocenter on the hydrogenation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617562d3a9006a6c4f0a9d4bc4b42aad
https://doi.org/10.1021/jo005726s
https://doi.org/10.1021/jo005726s
Autor:
Marta Nevalainen, Ari M. P. Koskinen
Publikováno v:
Synlett. 2001:0640-0642
(4R)-4[(tert-Butoxycarbonyl)amino]-2-methyl-2-penten-5-olide was synthesized and hydrogenated under various catalyst/solvent systems. The best cis/trans ratio was obtained with Rh/C in diethyl ether (dr = 90 : 10). After one recrystallization, (2S,4R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c988c9b7981d16376db08dcfc457cbf3
https://doi.org/10.1055/s-2001-13380
https://doi.org/10.1055/s-2001-13380