TMEM219 regulates the transcription factor expression and proliferation of beta cells

Autor: Francesca D’Addio, Emma Assi, Anna Maestroni, Giada Rossi, Vera Usuelli, Adriana Petrazzuolo, Marta Nardini, Cristian Loretelli, Moufida Ben Nasr, Paolo Fiorina

Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)

Pancreatic beta cells replenishment is considered the next therapeutic option for type 1 diabetes; while stimulating endogenous beta cells proliferation is the “holy grail” for those patients with exhausted beta cell mass. Here we are demonstrati

Externí odkaz: https://doaj.org/article/3c19f5f129a14d3dadfdbfbfd1eeb6c7

Growth Factors Delivery System for Skin Regeneration: An Advanced Wound Dressing

Autor: Marta Nardini, Sara Perteghella, Luca Mastracci, Federica Grillo, Giorgio Marrubini, Elia Bari, Matteo Formica, Chiara Gentili, Ranieri Cancedda, Maria Luisa Torre, Maddalena Mastrogiacomo

Publikováno v: Pharmaceutics, Vol 12, Iss 2, p 120 (2020)

Standard treatments of chronic skin ulcers based on the direct application of dressings still present several limits with regard to a complete tissue regeneration. Innovative strategies in tissue engineering offer materials that can tune cell behavio

Externí odkaz: https://doaj.org/article/bbc1bda60864402a85b2442a528b774b

Platelet Lysate Inhibits NF-κB Activation and Induces Proliferation and an Alert State in Quiescent Human Umbilical Vein Endothelial Cells Retaining Their Differentiation Capability

Autor: Alessio Romaldini, Valentina Ulivi, Marta Nardini, Maddalena Mastrogiacomo, Ranieri Cancedda, Fiorella Descalzi

Publikováno v: Cells, Vol 8, Iss 4, p 331 (2019)

Injured blood vessel repair and blood circulation re-establishment are crucial events for tissue repair. We investigated in primary cultures of human umbilical vein endothelial cells (HUVEC), the effects of platelet lysate (PL), a cocktail of factors

Externí odkaz: https://doaj.org/article/637090481e124802a838e4f3a767b3ea

Platelet lysate induces in human osteoblasts resumption of cell proliferation and activation of pathways relevant for revascularization and regeneration of damaged bone

Autor: Van Thi Nguyen, Fiorella Descalzi, Maddalena Mastrogiacomo, Alessandra Ruggiu, Ranieri Cancedda, Marta Nardini

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 5123, p 5123 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences (Int J Mol Sci)
Volume 21
Issue 14

To understand the regenerative effect of platelet-released molecules in bone repair one should investigate the cascade of events involving the resident osteoblast population during the reconstructive process. Here the in vitro response of human osteo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b89bfdd0a023cb6341bb0e712e40291
http://hdl.handle.net/11567/1076312

Electrospun silk fibroin fibers for storage and controlled release of human platelet lysate

Autor: Cataldo Pignatelli, Marta Nardini, Ranieri Cancedda, Athanassia Athanassiou, Giovanni Perotto, Maddalena Mastrogiacomo

Publikováno v: Acta Biomaterialia. 73:365-376

Human platelet lysate (hPL) is a pool of growth factors and cytokines able to induce regeneration of different tissues. Despite its good potentiality as therapeutic tool for regenerative medicine applications, hPL has been only moderately exploited i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093a3f7fcf97af60fa8fb5e268a9c456
https://doi.org/10.1016/j.actbio.2018.04.025