Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Marta Miaczynska"'
Autor:
Lidia Wolińska‐Nizioł, Karolina Romaniuk, Karolina Wojciechowska, Krzysztof Surga, Maciej Kamaszewski, Hubert Szudrowicz, Marta Miączyńska
Publikováno v:
FEBS Open Bio, Vol 12, Iss 8, Pp 1453-1464 (2022)
Tollip is a multifunctional adaptor protein implicated in innate immunity, lysosomal trafficking/autophagy of protein aggregates and various signaling processes in mammalian models. To verify evolutionary conservation of these functions, we used CRIS
Externí odkaz:
https://doaj.org/article/d362743235e744fe8cd41f56d412e672
Autor:
Marta Poźniak, Natalia Porębska, Kamil Jastrzębski, Mateusz Adam Krzyścik, Marika Kucińska, Weronika Zarzycka, Agnieszka Barbach, Małgorzata Zakrzewska, Jacek Otlewski, Marta Miączyńska, Łukasz Opaliński
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-21 (2021)
Abstract Background Overexpression of FGFR1 is observed in numerous tumors and therefore this receptor constitutes an attractive molecular target for selective cancer treatment with cytotoxic conjugates. The success of cancer therapy with cytotoxic c
Externí odkaz:
https://doaj.org/article/62043f3c34124fccac65d60cd456bc98
Autor:
Ewelina Szymańska, Paulina Nowak, Krzysztof Kolmus, Magdalena Cybulska, Krzysztof Goryca, Edyta Derezińska‐Wołek, Anna Szumera‐Ciećkiewicz, Marta Brewińska‐Olchowik, Aleksandra Grochowska, Katarzyna Piwocka, Monika Prochorec‐Sobieszek, Michał Mikula, Marta Miączyńska
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp 1-21 (2020)
Abstract Somatic copy number alterations play a critical role in oncogenesis. Loss of chromosomal regions containing tumor suppressors can lead to collateral deletion of passenger genes. This can be exploited therapeutically if synthetic lethal partn
Externí odkaz:
https://doaj.org/article/8cc5cfe1973f4294b821d6647809e978
Autor:
Magdalena Banach-Orłowska, Renata Wyszyńska, Beata Pyrzyńska, Małgorzata Maksymowicz, Jakub Gołąb, Marta Miączyńska
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-19 (2019)
Abstract Background Lymphotoxin β receptor (LTβR) plays important roles in the development of the immune system and immune response. At the cellular level, ligand-bound LTβR activates the pro-inflammatory NF-κB pathway but the detailed mechanisms
Externí odkaz:
https://doaj.org/article/24fc956adf8b4065bdfb525c623d93be
Autor:
Marta Pozniak, Aleksandra Sokolowska‐Wedzina, Kamil Jastrzebski, Jakub Szymczyk, Natalia Porebska, Mateusz Adam Krzyscik, Malgorzata Zakrzewska, Marta Miaczynska, Jacek Otlewski, Lukasz Opalinski
Publikováno v:
Molecular Oncology, Vol 14, Iss 9, Pp 1998-2021 (2020)
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitu
Externí odkaz:
https://doaj.org/article/41add822f32c4099b544103cf1062b2c
Autor:
Jaroslaw Cendrowski, Marta Kaczmarek, Michał Mazur, Katarzyna Kuzmicz-Kowalska, Kamil Jastrzebski, Marta Brewinska-Olchowik, Agata Kominek, Katarzyna Piwocka, Marta Miaczynska
Publikováno v:
eLife, Vol 9 (2020)
Intracellular transport undergoes remodeling upon cell differentiation, which involves cell type-specific regulators. Bone morphogenetic protein 2-inducible kinase (BMP2K) has been potentially implicated in endocytosis and cell differentiation but it
Externí odkaz:
https://doaj.org/article/c77b17a0a3e94ea190e786e56f36cb1b
Autor:
Anna Toruń, Ewelina Szymańska, Irinka Castanon, Lidia Wolińska-Nizioł, Anna Bartosik, Kamil Jastrzębski, Magdalena Miętkowska, Marcos González-Gaitán, Marta Miaczynska
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130818 (2015)
Many adaptor proteins involved in endocytic cargo transport exhibit additional functions in other cellular processes which may be either related to or independent from their trafficking roles. The endosomal adaptor protein Tollip is an example of suc
Externí odkaz:
https://doaj.org/article/f6c9fa9512524b37b9ca5224920819ac
Autor:
Surui Wang, Jaroslaw Cendrowski, Revathi Rekar, Karsten Motzler, Yun Kwon, Susanne Seitz, Michael Roden, Adriano Maida, Stephan Herzig, Marta Miaczynska, Anja Zeigerer
Publikováno v:
Zeitschrift für Gastroenterologie.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::399537f5890350eba92968d4bf055887
https://doi.org/10.1055/s-0041-1740751
https://doi.org/10.1055/s-0041-1740751
Autor:
Revathi Sekar, Karsten Motzler, Yun Kwon, Aaron Novikoff, Julia Jülg, Bahar Najafi, Surui Wang, Anna-Luisa Warnke, Susanne Seitz, Daniela Hass, Sofiya Gancheva, Sabine Kahl, Bin Yang, Brian Finan, Kathrin Schwarz, Juergen G. Okun, Michael Roden, Matthias Blüher, Timo D. Müller, Natalie Krahmer, Christian Behrends, Oliver Plettenburg, Marta Miaczynska, Stephan Herzig, Anja Zeigerer
Publikováno v:
Cell metabolism 34 (2022), Nr. 11
Cell metabolism
Cell Metab. 34, 1824-1842.e9 (2022)
Cell metabolism
Cell Metab. 34, 1824-1842.e9 (2022)
During mammalian energy homeostasis, the glucagon receptor (Gcgr) plays a key role in regulating both glucose and lipid metabolisms. However, the mechanisms by which these distinct signaling arms are differentially regulated remain poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f16941faa007e9843f2d5c89c05a11b
https://doi.org/10.1016/j.cmet.2022.10.013
https://doi.org/10.1016/j.cmet.2022.10.013
Publikováno v:
Cellular and molecular life sciences : CMLS. 79(6)
AXL, a TAM receptor tyrosine kinase (RTK), and its ligand growth arrest-specific 6 (GAS6) are implicated in cancer metastasis and drug resistance, and cellular entry of viruses. Given this, AXL is an attractive therapeutic target, and its inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae74921ff292de64b399c16edb862dd0
https://pubmed.ncbi.nlm.nih.gov/35622156
https://pubmed.ncbi.nlm.nih.gov/35622156