Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Marta Miączyńska"'
Autor:
Lidia Wolińska‐Nizioł, Karolina Romaniuk, Karolina Wojciechowska, Krzysztof Surga, Maciej Kamaszewski, Hubert Szudrowicz, Marta Miączyńska
Publikováno v:
FEBS Open Bio, Vol 12, Iss 8, Pp 1453-1464 (2022)
Tollip is a multifunctional adaptor protein implicated in innate immunity, lysosomal trafficking/autophagy of protein aggregates and various signaling processes in mammalian models. To verify evolutionary conservation of these functions, we used CRIS
Externí odkaz:
https://doaj.org/article/d362743235e744fe8cd41f56d412e672
Autor:
Marta Poźniak, Natalia Porębska, Kamil Jastrzębski, Mateusz Adam Krzyścik, Marika Kucińska, Weronika Zarzycka, Agnieszka Barbach, Małgorzata Zakrzewska, Jacek Otlewski, Marta Miączyńska, Łukasz Opaliński
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-21 (2021)
Abstract Background Overexpression of FGFR1 is observed in numerous tumors and therefore this receptor constitutes an attractive molecular target for selective cancer treatment with cytotoxic conjugates. The success of cancer therapy with cytotoxic c
Externí odkaz:
https://doaj.org/article/62043f3c34124fccac65d60cd456bc98
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-21 (2020)
Abstract Background Lymphotoxin β receptor (LTβR) is a member of tumor necrosis factor receptor (TNFR) superfamily which regulates the immune response. At the cellular level, upon ligand binding, the receptor activates the pro-inflammatory NF-κB a
Externí odkaz:
https://doaj.org/article/eeb13008f5bf4823a800efa82177285d
Autor:
Magdalena Banach-Orłowska, Renata Wyszyńska, Beata Pyrzyńska, Małgorzata Maksymowicz, Jakub Gołąb, Marta Miączyńska
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-19 (2019)
Abstract Background Lymphotoxin β receptor (LTβR) plays important roles in the development of the immune system and immune response. At the cellular level, ligand-bound LTβR activates the pro-inflammatory NF-κB pathway but the detailed mechanisms
Externí odkaz:
https://doaj.org/article/24fc956adf8b4065bdfb525c623d93be
Autor:
Ewelina Szymańska, Paulina Nowak, Krzysztof Kolmus, Magdalena Cybulska, Krzysztof Goryca, Edyta Derezińska‐Wołek, Anna Szumera‐Ciećkiewicz, Marta Brewińska‐Olchowik, Aleksandra Grochowska, Katarzyna Piwocka, Monika Prochorec‐Sobieszek, Michał Mikula, Marta Miączyńska
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)
Abstract Somatic copy number alterations play a critical role in oncogenesis. Loss of chromosomal regions containing tumor suppressors can lead to collateral deletion of passenger genes. This can be exploited therapeutically if synthetic lethal partn
Externí odkaz:
https://doaj.org/article/8cc5cfe1973f4294b821d6647809e978
Autor:
Marta Miączyńska, Marta Jakubik, Kamil Jastrzębski, Agata Poświata, Kamila Kozik, Daria Zdżalik-Bielecka
Supplementary Data from Bemcentinib and Gilteritinib Inhibit Cell Growth and Impair the Endo-Lysosomal and Autophagy Systems in an AXL-Independent Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb233856f2788ac9472ae06689dafca4
https://doi.org/10.1158/1541-7786.22527815
https://doi.org/10.1158/1541-7786.22527815
Autor:
Magdalena Oroń, Marcin Grochowski, Akanksha Jaiswar, Justyna Legierska, Kamil Jastrzębski, Magdalena Nowak-Niezgoda, Małgorzata Kołos, Wojciech Kaźmierczak, Tomasz Olesiński, Małgorzata Lenarcik, Magdalena Cybulska, Michał Mikuła, Alicja Żylicz, Marta Miączyńska, Katherina Zettl, Jacek R. Wiśniewski, Dawid Walerych
Human neoplasias are often addicted to the cellular proteasome machinery. This has led to the development of bortezomib and carfilzomib proteasome inhibitors, approved for the treatment of multiple myeloma. Cancers, however, were found resistant to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8a11310af7ca41fda95f391d3338035
https://doi.org/10.1101/2021.11.16.468807
https://doi.org/10.1101/2021.11.16.468807
Autor:
Mateusz Adam Krzyścik, Marta Poźniak, Agnieszka Barbach, Marika Kucińska, Malgorzata Zakrzewska, Kamil Jastrzębski, Weronika Zarzycka, Marta Miączyńska, Natalia Porębska, Jacek Otlewski, Łukasz Opaliński
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-21 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-21 (2021)
Background Overexpression of FGFR1 is observed in numerous tumors and therefore this receptor constitutes an attractive molecular target for selective cancer treatment with cytotoxic conjugates. The success of cancer therapy with cytotoxic conjugates
Autor:
Magdalena Oroń, Marcin Grochowski, Akanksha Jaiswar, Justyna Legierska, Kamil Jastrzębski, Magdalena Nowak-Niezgoda, Małgorzata Kołos, Wojciech Kaźmierczak, Tomasz Olesiński, Małgorzata Lenarcik, Magdalena Cybulska, Michał Mikula, Alicja Żylicz, Marta Miączyńska, Katharina Zettl, Jacek R. Wiśniewski, Dawid Walerych
Publikováno v:
Cell Reports. 40:111428
Proteasome machinery is a major proteostasis control system in human cells, actively compensated upon its inhibition. To understand this compensation, we compared global protein landscapes upon the proteasome inhibition with carfilzomib, in normal fi
Autor:
Marta Wróbel, Jarosław Cendrowski, Ewelina Szymańska, Malwina Grębowicz-Maciukiewicz, Noga Budick-Harmelin, Matylda Macias, Aleksandra Szybińska, Michał Mazur, Krzysztof Kolmus, Krzysztof Goryca, Michalina Dąbrowska, Agnieszka Paziewska, Michał Mikula, Marta Miączyńska
Publikováno v:
Life Science Alliance. 5:e202101239
Within the endolysosomal pathway in mammalian cells, ESCRT complexes facilitate degradation of proteins residing in endosomal membranes. Here, we show that mammalian ESCRT-I restricts the size of lysosomes and promotes degradation of proteins from ly