Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Marta Martinez‐Vicente"'
Autor:
Sunny Malhotra, Nicolas Fissolo, Carmen Rodríguez‐Rivera, Enric Monreal, Marta Montpeyo, Elena Urcelay, Juan Carlos Triviño, María José Pérez‐García, Miguel F. Segura, Agustín Pappolla, Jordi Río, Andreu Vilaseca, José Ignacio Fernández Velasco, Andrés Miguez, Carlos Goicoechea, Marta Martinez‐Vicente, Luisa M Villar, Xavier Montalban, Manuel Comabella
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 4, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/c4c6c2fc280e4866a272562127ef32f3
Autor:
Alba Navarro-Romero, Irene Fernandez-Gonzalez, Jordi Riera, Marta Montpeyo, Merce Albert-Bayo, Tresa Lopez-Royo, Pablo Castillo-Sanchez, Clara Carnicer-Caceres, Jose Antonio Arranz-Amo, Laura Castillo-Ribelles, Eddie Pradas, Josefina Casas, Miquel Vila, Marta Martinez-Vicente
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-15 (2022)
Abstract Mutations in the GBA gene that encodes the lysosomal enzyme β-glucocerebrosidase (GCase) are a major genetic risk factor for Parkinson’s disease (PD). In this study, we generated a set of differentiated and stable human dopaminergic cell
Externí odkaz:
https://doaj.org/article/7468460f4b9543b4905ae2accc258d51
Autor:
Rut Valdor, Marta Martinez-Vicente
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 257 (2024)
Chaperone-mediated autophagy (CMA) is a selective proteolytic pathway in the lysosomes. Proteins are recognized one by one through the detection of a KFERQ motif or, at least, a KFERQ-like motif, by a heat shock cognate protein 70 (Hsc70), a molecula
Externí odkaz:
https://doaj.org/article/29a110fbf85b47aa8bc3777d10b59ab6
Autor:
Marta Correa‐Vela, Vincenzo Lupo, Marta Montpeyó, Paula Sancho, Anna Marcé‐Grau, Jorge Hernández‐Vara, Alejandra Darling, Alison Jenkins, Sandra Fernández‐Rodríguez, Cristina Tello, Laura Ramírez‐Jiménez, Belén Pérez, Ángel Sánchez‐Montáñez, Alfons Macaya, María J. Sobrido, Marta Martinez‐Vicente, Belén Pérez‐Dueñas, Carmen Espinós
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 8, Pp 1436-1442 (2020)
Abstact FBXO7 is implicated in the ubiquitin–proteasome system and parkin‐mediated mitophagy. FBXO7defects cause a levodopa‐responsive parkinsonian‐pyramidal syndrome(PPS). Methods: We investigated the disease molecular bases in a child with
Externí odkaz:
https://doaj.org/article/5962ad217fd2467d95a29552c3e8210a
Autor:
Raquel Larramona-Arcas, Candela González-Arias, Gertrudis Perea, Antonia Gutiérrez, Javier Vitorica, Tamara García-Barrera, José Luis Gómez-Ariza, Raquel Pascua-Maestro, María Dolores Ganfornina, Eleanna Kara, Eloise Hudry, Marta Martinez-Vicente, Miquel Vila, Elena Galea, Roser Masgrau
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-23 (2020)
Abstract Background The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes structural and functional alterations in normal brains, and is the strongest genetic risk factor of the sporadic form of Alz
Externí odkaz:
https://doaj.org/article/d54845f1ed0141cba4bad31da880a522
Autor:
Eddie Pradas, Marta Martinez-Vicente
Publikováno v:
Cells, Vol 12, Iss 1, p 191 (2023)
GBA gene variants were the first genetic risk factor for Parkinson’s disease. GBA encodes the lysosomal enzyme glucocerebrosidase (GBA), which is involved in sphingolipid metabolism. GBA exhibits a complex physiological function that includes not o
Externí odkaz:
https://doaj.org/article/699395ddd62441518913e9982af52761
Autor:
Iria Carballo-Carbajal, Ariadna Laguna, Jordi Romero-Giménez, Thais Cuadros, Jordi Bové, Marta Martinez-Vicente, Annabelle Parent, Marta Gonzalez-Sepulveda, Núria Peñuelas, Albert Torra, Beatriz Rodríguez-Galván, Andrea Ballabio, Takafumi Hasegawa, Analía Bortolozzi, Ellen Gelpi, Miquel Vila
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent
Externí odkaz:
https://doaj.org/article/0fbc1ef6e5e046b1873667d6a11b3aa6
Publikováno v:
Cells, Vol 9, Iss 11, p 2399 (2020)
Lysosomal function has a central role in maintaining neuronal homeostasis, and, accordingly, lysosomal dysfunction has been linked to neurodegeneration and particularly to Parkinson’s disease (PD). Lysosomes are the converging step where the substr
Externí odkaz:
https://doaj.org/article/f00f10a0147e479b9582e2cca8ef53bc
Autor:
Marta Martinez-Vicente
Publikováno v:
Cells, Vol 9, Iss 2, p 495 (2020)
Autophagy induction is an attractive therapeutic approach to ameliorate aggregate accumulation in many neurodegenerative diseases [...]
Externí odkaz:
https://doaj.org/article/17d4d7752410436394a7cc60dc250479
Autor:
Stefanie Lerche, Isabel Wurster, Enza Maria Valente, Micol Avenali, Daniela Samaniego, Marta Martínez-Vicente, Jorge Hernández-Vara, Ariadna Laguna, Andrea Sturchio, Per Svenningsson, Nicholas P. France, Carrolee Barlow, Sethu Sankaranarayanan, Kathrin Brockmann
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-6 (2024)
Abstract Variants in GBA1 result in dysregulated sphingolipids. We investigated five CSF d18:1 sphingolipid species in a longitudinal multicenter cohort comprising people with Parkinson’s Disease and Dementia with Lewy bodies with and without GBA1
Externí odkaz:
https://doaj.org/article/0432f15037794f51a76f397dcdb3ce10