Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine

Autor: Niels Hagenaars, Clemens W.G.M. Löwik, Jacco G. M. Heldens, Harrie L. Glansbeek, Han van den Bosch, Wim Jiskoot, Bram Slütter, Eric L. Kaijzel, Rob Nieuwland, Ivo Que, Enrico Mastrobattista, Pascal H.J.L.F. de Jong, Marta Mania

Publikováno v: Journal of Controlled Release, 144(1), 17-24
Journal of Controlled Release, 144(1), 17-24. Elsevier
Hagenaars, N, Mania, M, De Jong, P, Que, I, Nieuwland, R, Slütter, B, Glansbeek, H, Heldens, J, van den Bosch, H, Löwik, C, Kaijzel, E L, Mastrobattista, E & Jiskoot, W 2010, ' Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine ', Journal of Controlled Release, vol. 144, no. 1, pp. 17-24 . https://doi.org/10.1016/j.jconrel.2010.01.027

The nose is a promising immunization site and intranasal (in.) vaccination studies with whole inactivated influenza virus (WIV) adjuvanted with N,N,N-trimethylchitosan (TMC-WIV) have shown promising results. In this study, the influence of TMC on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7ec3d29fcc22c71e383d07c8b31d70
https://pubmed.ncbi.nlm.nih.gov/20100528