Deregulation of secondary metabolism in a histone deacetylase mutant of Penicillium chrysogenum

Autor: Jeroen Kuipers, Roel A. L. Bovenberg, Marco Ries, Fernando Guzmán-Chávez, Oleksandr Salo, Rob J. Vreeken, Arnold J. M. Driessen, Marta M. Samol

Publikováno v: MicrobiologyOpen
MicrobiologyOpen, 7(5):e00598. Wiley

The Pc21 g14570 gene of Penicillium chrysogenum encodes an ortholog of a class 2 histone deacetylase termed HdaA which may play a role in epigenetic regulation of secondary metabolism. Deletion of the hdaA gene induces a significant pleiotropic effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d264605abc2b3e3aff7cba3c8fb3d97
https://hdl.handle.net/11370/c9dc80b8-e7af-42d1-a2ea-fc77a25c2b5c

Deregulation of secondary metabolism in a histone deacetylase mutant of Penicillium chrysogenum.

Autor: Guzman-Chavez F; Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.; Kluyver Centre for Genomics of Industrial Fermentations, Delft, The Netherlands., Salo O; Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.; Kluyver Centre for Genomics of Industrial Fermentations, Delft, The Netherlands., Samol M; Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.; Kluyver Centre for Genomics of Industrial Fermentations, Delft, The Netherlands., Ries M; Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Leiden, The Netherlands.; Netherlands Metabolomics Centre, Leiden University, Leiden, The Netherlands., Kuipers J; Department of Cell biology, University Medical Center Groningen, Groningen, The Netherlands., Bovenberg RAL; Synthetic Biology and Cell Engineering, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.; DSM Biotechnology Center, Delft, The Netherlands., Vreeken RJ; Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Leiden, The Netherlands.; Netherlands Metabolomics Centre, Leiden University, Leiden, The Netherlands., Driessen AJM; Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.; Kluyver Centre for Genomics of Industrial Fermentations, Delft, The Netherlands.

Publikováno v: MicrobiologyOpen [Microbiologyopen] 2018 Oct; Vol. 7 (5), pp. e00598. Date of Electronic Publication: 2018 Mar 24.