Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Marta Lopez-Pelaez"'
Autor:
Marta Lopez-Pelaez, Lucy Young, Mercedes Vazquez-Chantada, Nadine Nelson, Steve Durant, Robert W. Wilkinson, Edmund Poon, Miguel Gaspar, Viia Valge-Archer, Paul Smith, Simon J. Dovedi
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The concept of exploiting tumor intrinsic deficiencies in DNA damage repair mechanisms by inhibiting compensatory DNA repair pathways is well established. For example, ATM-deficient cells show increased sensitivity to the ATR inhibitor ceralasertib.
Externí odkaz:
https://doaj.org/article/9d2d450388024f9abe63eda60fc9f35d
Autor:
Nadine Nelson, Marta Lopez-Pelaez, Asis Palazon, Edmund Poon, Maike De La Roche, Simon Barry, Viia Valge-Archer, Robert W. Wilkinson, Simon J. Dovedi, Paul D. Smith
Publikováno v:
OncoImmunology, Vol 8, Iss 8, Pp 1-10 (2019)
In vitro assays that evaluate CD8+ T cell-mediated cytotoxicity are important to aid in the development of novel therapeutic approaches to enhance anti-tumor immune responses. Here, we describe a novel cytotoxicity co-culture assay that circumvents t
Externí odkaz:
https://doaj.org/article/bef43dac3ea74350878e6dc63b21d270
Publikováno v:
The Journal of Immunology Author Choice
Polymorphisms in the TNIP1 gene encoding A20-binding inhibitor of NF-κB1 (ABIN1) predispose to lupus and other autoimmune diseases in at least eight human populations. We found previously that knock-in mice expressing a ubiquitin-binding–defective
Autor:
Nadine, Nelson, Marta, Lopez-Pelaez, Asis, Palazon, Edmund, Poon, Maike, De La Roche, Simon, Barry, Viia, Valge-Archer, Robert W, Wilkinson, Simon J, Dovedi, Paul D, Smith
Publikováno v:
Oncoimmunology
In vitro assays that evaluate CD8+ T cell-mediated cytotoxicity are important to aid in the development of novel therapeutic approaches to enhance anti-tumor immune responses. Here, we describe a novel cytotoxicity co-culture assay that circumvents t
Autor:
Irene Soria-Castro, Gema Ferrer, Rosario Rodríguez-Ramos, Susana Alemany, Javier Regadera, Agnieszka Krzyzanowska, Lluis Montoliu, Marta Lopez Pelaez, Margarita Fernández
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Cot/tpl2 (also known as MAP3K8) has emerged as a new and potentially interesting therapeutic anti-inflammatory target. Here, we report the first study of Cot/tpl2 involvement in acute peripheral inflammation in vivo. Six hours after an intraplantar i