Výsledky vyhledávání - "Marta Lopes Lima"

Akademický článek

Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria

Autor: Tatiana Rodrigues Alexandre, Marta Lopes Lima, Mariana Kolos Galuppo, Juliana Tonini Mesquita, Matilia Ana do Nascimento, Augusto Leonardo dos Santos, Patricia Sartorelli, Daniel Carvalho Pimenta, Andre Gustavo Tempone

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 23, Iss 1, Pp 1-10 (2017)

Abstract Background Major drawbacks of the available treatment against Chagas disease (American trypanosomiasis) include its toxicity and therapeutic inefficiency in the chronic phase of the infection, which makes it a concern among neglected disease

Externí odkaz: https://doaj.org/article/217baf611d2145858a80082097335587

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Antileishmanial Activities of (

Autor: Latifeh, Navidpour, Marta Lopes, Lima, Rachel, Milne, Susan, Wyllie, Narges, Hadj-Esfandiari, Muhammad Iqbal, Choudhary, Samreen, Khan, Sammer, Yousuf

Publikováno v: Antimicrob Agents Chemother

The antileishmanial activity of a series of (Z)-2-(heteroarylmethylene)-3(2H)-benzofuranone derivatives, possessing 5-nitroimidazole or 4-nitroimidazole moieties, was investigated against Leishmania major promastigotes and some analogues exhibited pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::351175d825cd1a2d350b08052bca4da8
https://pubmed.ncbi.nlm.nih.gov/36286539

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Antileishmanial Activities of ( Z )-2-(Nitroimidazolylmethylene)-3( 2H )-Benzofuranones: Synthesis, In Vitro Assessment, and Bioactivation by NTR 1 and 2

Autor: Latifeh Navidpour, Marta Lopes Lima, Rachel Milne, Susan Wyllie, Narges Hadj-esfandiari, Muhammad Iqbal Choudhary, Samreen Khan, Sammer Yousuf

Publikováno v: Antimicrobial Agents and Chemotherapy. 66

The antileishmanial activity of a series of ( Z )-2-(heteroarylmethylene)-3(2 H )-benzofuranone derivatives, possessing 5-nitroimidazole or 4-nitroimidazole moieties, was investigated against Leishmania major promastigotes and some analogues exhibite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::774e8caef935bb05cab281146b9ed2dd
https://doi.org/10.1128/aac.00583-22

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Akademický článek

Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice.

Autor: Edézio Ferreira Cunha-Júnior, Valter Viana Andrade-Neto, Marta Lopes Lima, Thais Alves da Costa-Silva, Andres J Galisteo Junior, Maria A Abengózar, Coral Barbas, Luis Rivas, Elmo Eduardo Almeida-Amaral, Andre Gustavo Tempone, Eduardo Caio Torres-Santos

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 1, p e0005281 (2017)

The leishmanicidal action of tricyclic antidepressants has been studied and evidences have pointed that their action is linked to inhibition of trypanothione reductase, a key enzyme in the redox metabolism of pathogenic trypanosomes. Cyclobenzaprine

Externí odkaz: https://doaj.org/article/28c6132da48d4a5bbb3836defb2f027e

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Energy metabolism as a target for cyclobenzaprine: A drug candidate against Visceral Leishmaniasis

Autor: Marta Lopes Lima, Maria A. Abengózar, Eduardo Caio Torres-Santos, Samanta Etel Treiger Borborema, Joanna Godzien, Ángeles López-Gonzálvez, Coral Barbas, Luis Rivas, Andre Gustavo Tempone

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Leishmaniases have a broad spectrum of clinical manifestations, ranging from a cutaneous to a progressive and fatal visceral disease. Chemotherapy is nowadays the almost exclusive way to fight the disease but limited by its scarce therapeutic arsenal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e0fd6aebb407b5bf88fcb2c64787d1
https://pubmed.ncbi.nlm.nih.gov/35841672

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Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease

Autor: Stephen Patterson, Marta Lopes Lima, Lorna MacLean, Susan Wyllie, David Horn, Lindsay B. Tulloch, Sonia Moniz, Ian H. Gilbert, Richard J. Wall, Victoriano Corpas-López, Fabio Zuccotto, Rachel Milne, Eva Rico, Carmine Marco Morgillo, Leah S. Torrie, Sandra Carvalho

Publikováno v: Antimicrobial Agents and Chemotherapy

Phenotypic screening identified an arylsulfonamide compound with activity against Trypanosoma cruzi, the causative agent of Chagas’ disease. Comprehensive mode of action studies revealed that this compound primarily targets the T. cruzi proteasome,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f49c0c376d173d0316cb726b4e7b804
https://pubmed.ncbi.nlm.nih.gov/34606338

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Evaluation of antileishmanial potential of the antidepressant escitalopram in Leishmania infantum

Autor: Marta Lopes Lima, Samanta Etel Treiger Borborema, Maiara Amaral, Andre G. Tempone

Publikováno v: Journal of pharmaceutical and biomedical analysis. 209

Neglected tropical diseases (NTDs) such as visceral leishmaniasis (VL) present a limited and toxic therapeutic arsenal, and drug repositioning represents a safe and cost-effective approach. In this work, we investigated the antileishmanial potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc548f7f5c8925f3876342e62e18c60b
https://pubmed.ncbi.nlm.nih.gov/34838348

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Estudo do mecanismo de ação de fármacos em Leishmania: uma abordagem metabolômica não dirigida

Autor: André Gustavo Tempone Cardoso, Marta Lopes Lima

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

A quimioterapia disponível para o tratamento das leishmanioses conta com um número reduzido de fármacos, com efeitos adversos severos e progressivo aumento de resistência. O reposicionamento de fármacos oferece uma grande oportunidade para intro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb14b3a4ed84d2e99f55413268ae132
https://doi.org/10.11606/t.99.2017.tde-13112017-090743

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Dissertation/ Thesis

Estudo do mecanismo de ação de fármacos em Leishmania: uma abordagem metabolômica não dirigida

Autor: Marta Lopes Lima

Publikováno v: Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/99/99131/tde-13112017-090743/

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Avaliação do potencial carcinogênico do Megazol, agente anti-chagásico, e obtenção de nanopartículas de poli(e-caprolactona) contendo Megazol

Autor: Marta Lopes Lima

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

Megazol (1-metil-2-(5-amino-1,3,4-tiadiazolil)-5-nitroimidazol) (MZ) tem sido descrito como um composto efetivo contra Tripanossoma cruzi, agente causador da Doença de Chagas. Contudo, este composto mostrou efeitos mutagênicos e baixa solubilidade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29063e173b78b802470279ced2ffec6
https://doi.org/10.11606/d.87.2011.tde-09022012-101718

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