Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Marta Kučerová-Chlupáčová"'
Autor:
Klára Konečná, Adéla Diepoltová, Pavlína Holmanová, Ondřej Jand’ourek, Marcela Vejsová, Barbora Voxová, Pavel Bárta, Jana Maixnerová, František Trejtnar, Marta Kučerová-Chlupáčová
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The greatest threat and medicinal impact within gram-positive pathogens are posed by two bacterial genera, Staphylococcus and Enterococcus. Chalcones have a wide range of biological activities and are recognized as effective templates in medicinal ch
Externí odkaz:
https://doaj.org/article/4da402bc3a974b44916136f26d267479
Autor:
Petr Šlechta, Adam Anthony Needle, Ondřej Jand’ourek, Pavla Paterová, Klára Konečná, Pavel Bárta, Jiří Kuneš, Vladimír Kubíček, Martin Doležal, Marta Kučerová-Chlupáčová
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2951 (2023)
Tuberculosis remains a serious killer among infectious diseases due to its incidence, mortality, and occurrence of resistant mycobacterial strains. The challenge to discover new antimycobacterial agents forced us to prepare a series of N-(1-hydroxy-1
Externí odkaz:
https://doaj.org/article/4fa4428dfe1442afbe0a7f273e8e7758
Publikováno v:
Molecules, Vol 28, Iss 3, p 1485 (2023)
Cancer is one of the leading causes of death worldwide, with nearly 10 million deaths in 2020 [...]
Externí odkaz:
https://doaj.org/article/6533c76884954c68a749ba518fb183e9
Review and Chemoinformatic Analysis of Ferroptosis Modulators with a Focus on Natural Plant Products
Publikováno v:
Molecules, Vol 28, Iss 2, p 475 (2023)
Ferroptosis is a regular cell death pathway that has been proposed as a suitable therapeutic target in cancer and neurodegenerative diseases. Since its definition in 2012, a few hundred ferroptosis modulators have been reported. Based on a literature
Externí odkaz:
https://doaj.org/article/10866afa6a0440588936e88f0e279f5b
Autor:
Petr Šlechta, Ondřej Jand’ourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Vladimír Kubíček, Martin Doležal, Marta Kučerová-Chlupáčová
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 133 (2022)
The current study is focused on the combination of pyrazinamide with 6-aminobenzo[c][1,2]oxaborol-1(3H)-ol, which is a crucial pharmacophore of several antimicrobial agents. The use of benzoxaborole moiety could afford the formation of a spiro adduct
Externí odkaz:
https://doaj.org/article/e25ce61262bb44ff81190f948987b53c
Autor:
Weronika Ambrożkiewicz, Marta Kučerová-Chlupáčová, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Jarmila Vinšová, Martin Doležal, Jan Zitko
Publikováno v:
Molecules, Vol 25, Iss 7, p 1561 (2020)
According to the World Health Organization, tuberculosis is still in the top ten causes of death from a single infectious agent, killing more than 1.7 million people worldwide each year. The rising resistance developed by Mycobacterium tuberculosis a
Externí odkaz:
https://doaj.org/article/cbb2f0eea373485fbfbe31ebb479da48
Autor:
Višnja Stepanić, Mario Matijašić, Tea Horvat, Donatella Verbanac, Marta Kučerová-Chlupáčová, Luciano Saso, Neven Žarković
Publikováno v:
Antioxidants, Vol 8, Iss 4, p 90 (2019)
Chalcones are polyphenolic secondary metabolites of plants, many of which have antioxidant activity. Herein, a set of 26 synthetic chalcone derivatives with alkyl substituted pyrazine heterocycle A and four types of the monophenolic ring B, were eval
Externí odkaz:
https://doaj.org/article/20cff78f2b1c4223b2309b6670fcca07
Autor:
Weronika, Ambrożkiewicz, Marta, Kučerová-Chlupáčová, Ondřej, Janďourek, Klára, Konečná, Pavla, Paterová, Pavel, Bárta, Jarmila, Vinšová, Martin, Doležal, Jan, Zitko
Publikováno v:
Molecules
According to the World Health Organization, tuberculosis is still in the top ten causes of death from a single infectious agent, killing more than 1.7 million people worldwide each year. The rising resistance developed by Mycobacterium tuberculosis a
Publikováno v:
Molecules, Vol 20, Iss 1, Pp 1104-1117 (2015)
Infectious diseases, such as tuberculosis and invasive mycoses, represent serious health problems. As a part of our long-term efforts to find new agents for the treatment of these diseases, a new series of pyrazine analogs of chalcones bearing an iso
Externí odkaz:
https://doaj.org/article/c5358592ab314d22993aebb52347b90e
Autor:
Petra Hirsova, Jan Dolezel, Marta Kucerova-Chlupacova, Jiri Kunes, Veronika Pilarova, Lucie Novakova, Veronika Opletalova
Publikováno v:
Molbank, Vol 2015, Iss 4, p M872 (2015)
3-Aminorhodanine reacts with aldehydes to form either 5-[(aryl)alkylidene]-substituted products or Schiff bases or derivatives substituted at both the 3-amino group and the 5-methylene group, depending on the reaction conditions. In this note, synthe
Externí odkaz:
https://doaj.org/article/a429f8d788bd45bb9a00e051e5cf8b11