Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Marta Klejnot"'
Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity
Autor:
Karen H. Vousden, Marta Klejnot, Gary J. Sibbet, Dominika Kowalczyk, Danny T. Huang, Andreas K. Hock, Koji Nomura
Publikováno v:
Nature Structural & Molecular Biology
MDM2-MDMX complexes bind the p53 tumor suppressor protein, inhibiting p53’s transcriptional activity and targeting p53 for proteasomal degradation. Inhibitors that disrupt binding between p53 and MDM2 efficiently activate a p53 response although th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf8af8370f62e87a2153f9af3db7e59
Autor:
Frank Kozielski, Peter W. Baas, Robert A. Cross, Venkatasubramanian Ulaganathan, Marta Klejnot, Aditi Falnikar
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
'Acta Crystallographica D ', vol: 70, pages: 123-133 (2014)
'Acta Crystallographica D ', vol: 70, pages: 123-133 (2014)
The structural and biochemical study of Kif15 provides insight into this potential drug target and allows comparison with Eg5, a kinesin that partially shares the functions of Kif15.
Kinesins constitute a superfamily of microtubule-based motor p
Kinesins constitute a superfamily of microtubule-based motor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0445885ed40beb27b4e657021b3e55a
https://doi.org/10.1107/s1399004713028721
https://doi.org/10.1107/s1399004713028721
Autor:
Jorge Cuéllar, Patricia A.J. Muller, Karen H. Vousden, José M. Valpuesta, Marta Klejnot, Max Nobis, Antonio García Trinidad
Publikováno v:
Molecular Cell
Summary p53 is a transcription factor that mediates tumor suppressor responses. Correct folding of the p53 protein is essential for these activities, and point mutations that induce conformational instability of p53 are frequently found in cancers. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c208ad11630b5934a7b2f4915fd855
Autor:
Marta Klejnot, Frank Kozielski
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
The human Kif7 motor domain structure provides insights into a kinesin of medical significance.
Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It i
Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda29aceef134b781bce7d76904f8f15
http://europepmc.org/articles/PMC3266853
http://europepmc.org/articles/PMC3266853
Autor:
Gary J. Sibbet, Danny T. Huang, Marta Klejnot, Andreas K. Hock, Koji Nomura, Karen H. Vousden, Dominika Kowalczyk
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 73:a352-a352
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ccdcb324ee9d71c43f18c889dfe5579
https://doi.org/10.1107/s0108767317096568
https://doi.org/10.1107/s0108767317096568
Autor:
Andrew Pannifer, Mads Gabrielsen, Frank Kozielski, Andrzej Mleczak, Michael F. Olson, Sandeep K. Talapatra, Jenifer M. Cameron, Marta Klejnot
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 69(Pt 9)
The actin cytoskeleton is the chassis that gives a cell its shape and structure, and supplies the power for numerous dynamic processes including motility, endocytosis, intracellular transport and division. To perform these activities, the cytoskeleto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144cf34f5cc010fd12ab8f9faebbb8aa
https://pubmed.ncbi.nlm.nih.gov/23999301
https://pubmed.ncbi.nlm.nih.gov/23999301