Granulovacuolar degeneration bodies are independently induced by tau and α-synuclein pathology

Autor: Marta Jorge-Oliva, Jasper F. M. Smits, Vera I. Wiersma, Jeroen J. M. Hoozemans, Wiep Scheper

Publikováno v: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-21 (2022)

Abstract Background Granulovacuolar degeneration bodies (GVBs) are intracellular vesicular structures that commonly accompany pathological tau accumulations in neurons of patients with tauopathies. Recently, we developed the first model for GVBs in p

Externí odkaz: https://doaj.org/article/fe261881414643b7a659164fcb0891a1

Protein disulfide isomerases as CSF biomarkers for the neuronal response to tau pathology

Autor: Kimberly Wolzak, Lisa Vermunt, Marta del Campo, Marta Jorge‐Oliva, Anna Maria van Ziel, Ka Wan Li, August B. Smit, Alice Chen‐Ploktkin, David J. Irwin, Afina W. Lemstra, Yolande Pijnenburg, Wiesje van der Flier, Henrik Zetterberg, Johan Gobom, Kaj Blennow, Pieter Jelle Visser, Charlotte E. Teunissen, Betty M. Tijms, Wiep Scheper

Publikováno v: Alzheimer's and Dementia. Elsevier
Wolzak, K, Vermunt, L, Campo, M D, Jorge-Oliva, M, van Ziel, A M, Li, K W, Smit, A B, Chen-Ploktkin, A, Irwin, D J, Lemstra, A W, Pijnenburg, Y, van der Flier, W, Zetterberg, H, Gobom, J, Blennow, K, Visser, P J, Teunissen, C E, Tijms, B M & Scheper, W 2023, ' Protein disulfide isomerases as CSF biomarkers for the neuronal response to tau pathology ', Alzheimer's and Dementia . https://doi.org/10.1002/alz.12978
Alzheimer's & Dementia. Elsevier Science

Introduction: Cerebrospinal fluid (CSF) biomarkers for specific cellular disease processes are lacking for tauopathies. In this translational study we aimed to identify CSF biomarkers reflecting early tau pathology-associated unfolded protein respons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94faff12f82b5ed26620ab9eeef0c7f
http://www.scopus.com/inward/record.url?scp=85148657643&partnerID=8YFLogxK