C/EBPβ-dependent autophagy inhibition hinders NK cell function in cancer

Autor: Federica Portale, Roberta Carriero, Marta Iovino, Paolo Kunderfranco, Marta Pandini, Giulia Marelli, Nicolò Morina, Massimo Lazzeri, Paolo Casale, Piergiuseppe Colombo, Gabriele De Simone, Chiara Camisaschi, Enrico Lugli, Gianluca Basso, Javier Cibella, Sergio Marchini, Matteo Bordi, Greta Meregalli, Anna Garbin, Monica Dambra, Elena Magrini, Wiebke Rackwitz, Francesco Cecconi, Alessandro Corbelli, Fabio Fiordaliso, Jiri Eitler, Torsten Tonn, Diletta Di Mitri

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Abstract NK cells are endowed with tumor killing ability, nevertheless most cancers impair NK cell functionality, and cell-based therapies have limited efficacy in solid tumors. How cancers render NK cell dysfunctional is unclear, and overcoming resi

Externí odkaz: https://doaj.org/article/d96fe7cd9b7847dea66f22912cd5bddc

MP14-11 SINGLE CELL-BASED IMMUNE PROFILING OF THE TUMOR AND ITS IMMUNE MICROENVIRONMENT REVEALED DIFFERENCES BETWEEN NMIBC AND MIBC: IMPLICATION FOR IMMUNO-THERAPY

Autor: Massimo Lazzeri, NicolòMaria Buffi, Giovanni Lughezzani, Paolo Casale, Roberto Hurle, Alberto Saita, Vittorio Fasulo, Marco Paciotti, Marta Pandini, Roberta Carriero, Mattia Carvetta, Marta Iovino, Piergiuseppe Colombo, Grazia Elefante, Gianluca Basso, Sergio Marchini, Paolo Kunderfranco, Diletta Di Mitri

Publikováno v: Journal of Urology. 209

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::887aedff281a8764accdfde506be85d0
https://doi.org/10.1097/ju.0000000000003234.11

Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer

Autor: Michela Masetti, Roberta Carriero, Federica Portale, Giulia Marelli, Nicolò Morina, Marta Pandini, Marta Iovino, Bianca Partini, Marco Erreni, Andrea Ponzetta, Elena Magrini, Piergiuseppe Colombo, Grazia Elefante, Federico Simone Colombo, Joke M.M. den Haan, Clelia Peano, Javier Cibella, Alberto Termanini, Paolo Kunderfranco, Jolanda Brummelman, Matthew Wai Heng Chung, Massimo Lazzeri, Rodolfo Hurle, Paolo Casale, Enrico Lugli, Ronald A. DePinho, Subhankar Mukhopadhyay, Siamon Gordon, Diletta Di Mitri

Publikováno v: Journal of Experimental Medicine, 219(2):e20210564. Rockefeller University Press
Masetti, M, Carriero, R, Portale, F, Marelli, G, Morina, N, Pandini, M, Iovino, M, Partini, B, Erreni, M, Ponzetta, A, Magrini, E, Colombo, P, Elefante, G, Simone Colombo, F, den Haan, J M M, Peano, C, Cibella, J, Termanini, A, Kunderfranco, P, Brummelman, J, Chung, M W H, Lazzeri, M, Hurle, R, Casale, P, Lugli, E, DePinho, R A, Mukhopadhyay, S, Gordon, S & Di Mitri, D 2021, ' Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer ', Journal of Experimental Medicine, vol. 219, no. 2, e20210564 . https://doi.org/10.1084/jem.20210564

Tumor-associated macrophages (TAMs) are correlated with the progression of prostatic adenocarcinoma (PCa). The mechanistic basis of this correlation and therapeutic strategies to target TAMs in PCa remain poorly defined. Here, single-cell RNA sequenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037a35db79fb52deedf5e3a94f8ad206
https://doi.org/10.1084/jem.20210564