Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Marta I. Sierra"'
1
Akademický článek
No genome-wide DNA methylation changes found associated with medium-term reduced graphene oxide exposure in human lung epithelial cells
Autor: Raúl F. Pérez, Anna Yunuen Soto Fernández, Pablo Bousquets Muñoz, Marta I. Sierra, Juan Ramón Tejedor, Paula Morales-Sánchez, Adolfo F. Valdés, Ricardo Santamaría, Clara Blanco, Ramón Torrecillas, Mario F. Fraga, Agustín F. Fernández
Publikováno v: Epigenetics, Vol 15, Iss 3, Pp 283-293 (2020)
The presence of nanomaterials in our everyday life is ever increasing, and so too are concerns about the possible health consequences of exposure to them. While evidence of their biological activity is growing, there is still scant knowledge of the e
Externí odkaz: https://doaj.org/article/b24f321532884c4494a7246eb25681b2
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2
Akademický článek
DNA methylation reprogramming of human cancer cells by expression of a plant 5-methylcytosine DNA glycosylase
Autor: Teresa Morales-Ruiz, María Victoria García-Ortiz, Iván Devesa-Guerra, Laura Raya-Ruiz, Juan R. Tejedor, Gustavo F. Bayón, Marta I. Sierra, Mario F. Fraga, Rafael R. Ariza, Teresa Roldán-Arjona
Publikováno v: Epigenetics, Vol 13, Iss 1, Pp 95-107 (2018)
Patterns of DNA methylation, an important epigenetic modification involved in gene silencing and development, are disrupted in cancer cells. Understanding the functional significance of aberrant methylation in tumors remains challenging, due in part
Externí odkaz: https://doaj.org/article/716ad87d66bd4c03897422f5f20273f6
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3
No genome-wide DNA methylation changes found associated with medium-term reduced graphene oxide exposure in human lung epithelial cells
Autor: Ricardo Santamaría, Mario F. Fraga, Ramón Torrecillas, Adolfo F. Valdes, Agustín F. Fernández, Raúl F. Pérez, Marta I. Sierra, Paula Morales-Sánchez, Anna Yunuen Soto Fernández, Clara Blanco, Juan Ramón Tejedor, Pablo Bousquets Muñoz
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Epigenetics
The presence of nanomaterials in our everyday life is ever increasing, and so too are concerns about the possible health consequences of exposure to them. While evidence of their biological activity is growing, there is still scant knowledge of the e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d4f1fd449c969596b74a88525df1f7
https://doi.org/10.1080/15592294.2019.1666650
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4
Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases
Autor: Pierre Savatier, Nuria Montserrat, Laia Richart-Ginés, Camille Stephan-Otto Attolini, Raquel Bernad, Susana Prieto, Marta I. Sierra, Joaquín Pastor, Magdalena Zernicka-Goetz, Sonia Sánchez Martínez, Daniel Fisher, Javier Munoz, Sandrina Nóbrega-Pereira, Noelia Alcazar, Ana Martinez-Val, Gonzalo Gómez-López, Mario F. Fraga, Marta N. Shahbazi, Elisabeth Simboeck, Carmen Blanco-Aparicio, Elena Garreta, Osvaldo Graña-Castro, Alain Camasses, Irène Aksoy, Sagrario Ortega, Cian J. Lynch, Maribel Muñoz-Martin, Isabel A. Calvo, Agustín F. Fernández, Manuel Serrano, Carolina Tarantino
Publikováno v: Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2020, 22 (10), pp.1223-1238. ⟨10.1038/s41556-020-0573-1⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Cell Biology, 2020, 22 (10), pp.1223-1238. ⟨10.1038/s41556-020-0573-1⟩
research@ua; Vol 11 (2020); 49
research@ua; vol. 11 (2020); 49
Digital.CSIC. Repositorio Institucional del CSIC
instname
Pluripotent stem cells (PSCs) transition between cell states in vitro, reflecting developmental changes in the early embryo. PSCs can be stabilized in the naive state by blocking extracellular differentiation stimuli, particularly FGF–MEK signallin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e6662dbd5d60ba17897bdaeae5b24d
https://hal.archives-ouvertes.fr/hal-03234133
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5
Epigenetic dysregulation ofTET2in human glioblastoma
Autor: María-Dolores Chiara, Marta I. Sierra, Rocío G. Urdinguio, Mario F. Fraga, Pablo Santamarina, Raúl F. Pérez, Inés Sáenz-de-Santa-María, Antonella Carella, Virginia Lopez, Agustín F. Fernández, Cristina Mangas, Aurora Astudillo, Gustavo F. Bayón, María Begoña González García, M Daniela Corte-Torres, Juan Ramón Tejedor, Estela García-Toraño
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
Ten-eleven translocation (TET) enzymes are frequently deregulated in cancer, but the underlying molecular mechanisms are still poorly understood. Here we report that TET2 shows frequent epigenetic alterations in human glioblastoma including DNA hyper
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9391cc8d62f99d0f37b4dd42c05a99f8
https://doi.org/10.18632/oncotarget.25406
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6
Epigenetic downregulation of TET3 reduces genome-wide 5hmC levels and promotes glioblastoma tumorigenesis
Autor: Raúl F. Pérez, Agustín F. Fernández, Cristina Mangas, Marta I. Sierra, Pablo Santamarina-Ojeda, Antonella Carella, Rocío G. Urdinguio, Estela García-Toraño, Aurora Astudillo, Mario F. Fraga, Juan Ramón Tejedor, Bárbara Meléndez, María Begoña González García, María D. Corte-Torres, Manuela Mollejo, Gustavo F. Bayón, Timothée Bigot, Inés Sáenz-de-Santa-María, María D. Chiara, Virginia Lopez
Publikováno v: Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Digital.CSIC. Repositorio Institucional del CSIC
Loss of 5‐hydroxymethylcytosine (5hmC) has been associated with mutations of the ten–eleven translocation (TET) enzymes in several types of cancer. However, tumors with wild‐type TET genes can also display low 5hmC levels, suggesting that other
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feba9c1163efa60342df80ccc5cf05a8
http://hdl.handle.net/10651/53069
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7
Epigenetic deregulation of protocadherin PCDHGC3 in pheochromocytomas/paragangliomas associated with SDHB mutations
Autor: Juan Carlos Rial, María-Dolores Chiara, Maribel Del Olmo, Nuria Valdés, Laura Cacho, María Tous, Inés Sáenz-de-Santa-María, Paula Jiménez-Fonseca, Estrella Turienzo, Carlos Suárez, María-José Molina-Garrido, Isabel Tena, Miguel Ángel Hevia, Andrés San José Martinez, Lucía Celada, Cristóbal Bernardo-Castiñeira, Ana Vallejo, Teresa Serrano, Bartolomé Scola, Marta I. Sierra, Carles Villabona, Shobana Athimulam, Elena Navarro, Carmen Luz Menéndez, Irina Bancos, Aurora Astudillo, Mario F. Fraga, Carmen Bernardo, Agustín F. Fernández, Lluis Forga, Gustavo F. Bayón, Isabel Chirivella
Publikováno v: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
r-FHPC. Repositorio Institucional de Producción Científica de la Fundación del Hospital Provincial de Castellón
Digital.CSIC. Repositorio Institucional del CSIC
[Context]: SDHB mutations are found in an increasing number of neoplasms, most notably in paragangliomas and pheochromocytomas (PPGLs). SDHB-PPGLs are slow-growing tumors, but ∼50% of them may develop metastasis. The molecular basis of metastasis i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d784bafe8bf154ae23d0804f5a556d4
http://hdl.handle.net/10261/210818
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8
Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment
Autor: Carlos López-Larrea, María Jesús Cañal, Marija Dmitrijeva, Jesús Vallejo-Díaz, Anne K. Voss, Patricia C Pruneda, Inmaculada Hernández-López, Beatriz Suarez-Alvarez, Núria Sima-Teruel, Tim Thomas, María Begoña González García, Raúl F. Pérez, Virginia Lopez, Rainer Deutzmann, Teresa Bernal, Ana Villar-Garea, Marta I. Sierra, Antonella Carella, Ana C. Carrera, Daniel Rico, Osvaldo Graña-Castro, Alejandra Sanjuan-Pla, Elena Diaconu, Cristina Mangas, Cecilia Ferrero, Mario F. Fraga, Ana Pando-Sandoval, Pablo Santamarina, Laura Santos, Luis Valledor, David G. Pisano, Clara Bueno, Cristina Prieto, Cristina Bravo, Alejandro Vaquero, Juan Luis Fernández-Morera, María-Dolores Chiara, Francisco Rodríguez, Gustavo F. Bayón, Estela García-Toraño, Agustín F. Fernández, Ana Salas, Thalia Belmonte, Rafael Diaz de la Guardia, Juan Ramón Tejedor, Edward Seto, Milagros Balbín, Enrique Colado, Inés Sáenz-de-Santa-María, Rocío G. Urdinguio, Amparo Vayá, Luis Rodrigo, Pablo Menendez, Olivia García-Suárez, José M Ricart, Ramon M. Rodriguez
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Scopus
Nucleic Acids Research
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
RUO. Repositorio Institucional de la Universidad de Oviedo
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
NUCLEIC ACIDS RESEARCH
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly unde
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee781ba1d7bf3975d5365c81edeecf72
http://hdl.handle.net/2445/174855
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9
Loss of 5hmC identifies a new type of aberrant DNA hypermethylation in glioma
Autor: Félix Bonilla, María Begoña González García, Pablo Rodríguez-González, Agustín F. Fernández, Manuela Mollejo, Pablo Menendez, Bárbara Meléndez, Mario F. Fraga, Antonella Carella, Isabel Cobo, Luis Rodrigo, J. Ignacio Garcia Alonso, Virginia Lopez, Ignacio Ortea, Pablo Santamarina, Sergio Cueto Díaz, Gemma Domínguez, Rocío G. Urdinguio, Gustavo F. Bayón, Raúl F. Pérez, Thalia Belmonte, Aurora Astudillo, Cristina Mangas, Marta I. Sierra, Cecilia Ferrero, Juan Ramón Tejedor, Estela G. Toraño
Publikováno v: WOS:000444202300008
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Human Molecular Genetics
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
This work has been financially supported by: the Plan Nacional de IþDþI 2013–2016/FEDER (PI15/00892 to M.F.F. and A.F.F.; RTC2015-3393-1 to A.F.F.); the ISCIII-Subdirección General de Evaluación y Fomento de la Investigación, and the Plan Naci
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee93a9a4970d210fc2eea868c1208c5
http://hdl.handle.net/10651/49843
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