No genome-wide DNA methylation changes found associated with medium-term reduced graphene oxide exposure in human lung epithelial cells

Autor: Raúl F. Pérez, Anna Yunuen Soto Fernández, Pablo Bousquets Muñoz, Marta I. Sierra, Juan Ramón Tejedor, Paula Morales-Sánchez, Adolfo F. Valdés, Ricardo Santamaría, Clara Blanco, Ramón Torrecillas, Mario F. Fraga, Agustín F. Fernández

Publikováno v: Epigenetics, Vol 15, Iss 3, Pp 283-293 (2020)

The presence of nanomaterials in our everyday life is ever increasing, and so too are concerns about the possible health consequences of exposure to them. While evidence of their biological activity is growing, there is still scant knowledge of the e

Externí odkaz: https://doaj.org/article/b24f321532884c4494a7246eb25681b2

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

Autor: Pierre Savatier, Nuria Montserrat, Laia Richart-Ginés, Camille Stephan-Otto Attolini, Raquel Bernad, Susana Prieto, Marta I. Sierra, Joaquín Pastor, Magdalena Zernicka-Goetz, Sonia Sánchez Martínez, Daniel Fisher, Javier Munoz, Sandrina Nóbrega-Pereira, Noelia Alcazar, Ana Martinez-Val, Gonzalo Gómez-López, Mario F. Fraga, Marta N. Shahbazi, Elisabeth Simboeck, Carmen Blanco-Aparicio, Elena Garreta, Osvaldo Graña-Castro, Alain Camasses, Irène Aksoy, Sagrario Ortega, Cian J. Lynch, Maribel Muñoz-Martin, Isabel A. Calvo, Agustín F. Fernández, Manuel Serrano, Carolina Tarantino

Publikováno v: Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2020, 22 (10), pp.1223-1238. ⟨10.1038/s41556-020-0573-1⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Cell Biology, 2020, 22 (10), pp.1223-1238. ⟨10.1038/s41556-020-0573-1⟩
research@ua; Vol 11 (2020); 49
research@ua; vol. 11 (2020); 49
Digital.CSIC. Repositorio Institucional del CSIC
instname

Pluripotent stem cells (PSCs) transition between cell states in vitro, reflecting developmental changes in the early embryo. PSCs can be stabilized in the naive state by blocking extracellular differentiation stimuli, particularly FGF–MEK signallin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e6662dbd5d60ba17897bdaeae5b24d
https://hal.archives-ouvertes.fr/hal-03234133

Epigenetic downregulation of TET3 reduces genome-wide 5hmC levels and promotes glioblastoma tumorigenesis

Autor: Raúl F. Pérez, Agustín F. Fernández, Cristina Mangas, Marta I. Sierra, Pablo Santamarina-Ojeda, Antonella Carella, Rocío G. Urdinguio, Estela García-Toraño, Aurora Astudillo, Mario F. Fraga, Juan Ramón Tejedor, Bárbara Meléndez, María Begoña González García, María D. Corte-Torres, Manuela Mollejo, Gustavo F. Bayón, Timothée Bigot, Inés Sáenz-de-Santa-María, María D. Chiara, Virginia Lopez

Publikováno v: Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Digital.CSIC. Repositorio Institucional del CSIC

Loss of 5‐hydroxymethylcytosine (5hmC) has been associated with mutations of the ten–eleven translocation (TET) enzymes in several types of cancer. However, tumors with wild‐type TET genes can also display low 5hmC levels, suggesting that other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feba9c1163efa60342df80ccc5cf05a8
http://hdl.handle.net/10651/53069

Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment

Autor: Carlos López-Larrea, María Jesús Cañal, Marija Dmitrijeva, Jesús Vallejo-Díaz, Anne K. Voss, Patricia C Pruneda, Inmaculada Hernández-López, Beatriz Suarez-Alvarez, Núria Sima-Teruel, Tim Thomas, María Begoña González García, Raúl F. Pérez, Virginia Lopez, Rainer Deutzmann, Teresa Bernal, Ana Villar-Garea, Marta I. Sierra, Antonella Carella, Ana C. Carrera, Daniel Rico, Osvaldo Graña-Castro, Alejandra Sanjuan-Pla, Elena Diaconu, Cristina Mangas, Cecilia Ferrero, Mario F. Fraga, Ana Pando-Sandoval, Pablo Santamarina, Laura Santos, Luis Valledor, David G. Pisano, Clara Bueno, Cristina Prieto, Cristina Bravo, Alejandro Vaquero, Juan Luis Fernández-Morera, María-Dolores Chiara, Francisco Rodríguez, Gustavo F. Bayón, Estela García-Toraño, Agustín F. Fernández, Ana Salas, Thalia Belmonte, Rafael Diaz de la Guardia, Juan Ramón Tejedor, Edward Seto, Milagros Balbín, Enrique Colado, Inés Sáenz-de-Santa-María, Rocío G. Urdinguio, Amparo Vayá, Luis Rodrigo, Pablo Menendez, Olivia García-Suárez, José M Ricart, Ramon M. Rodriguez

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Scopus
Nucleic Acids Research
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
RUO. Repositorio Institucional de la Universidad de Oviedo
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
NUCLEIC ACIDS RESEARCH
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee781ba1d7bf3975d5365c81edeecf72
http://hdl.handle.net/2445/174855

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

Autor: Beiyuan Fu, Dieter Saur, Christian Veltkamp, Thomas Engleitner, Alex Strong, Wolfgang Enard, Sebastian Mueller, Sebastian Lange, Magdalena Zukowska, Nina Schönhuber, Thorsten Kaltenbacher, Mathias J Friedrich, Ruby Banerjee, Maxim Barenboim, Hsi-Yu Yen, Julia Hess, Pentao Liu, Barbara Seidler, Swati Parekh, Björn Konukiewitz, Sabine Klein, Maximilian Zwiebel, Jorge de la Rosa, Lena Rad, Roman Maresch, Stefan Eser, Allan Bradley, Kathleen Schuck, Fernando Constantino-Casas, Roland Rad, Juliana Götzfried, Sandra Louzada, Fengtang Yang, Günter Klöppel, Christoph Ziegenhain, Mario F. Fraga, Marta I. Sierra, Ignacio Varela, Juan Cadiñanos, Rupert Öllinger, Wilko Weichert, Zonera Hassan, Katja Steiger, Günter Schneider, Oliver M. Dovey, Julia Mayerle, Kristian Unger, George S. Vassiliou, Andreas Arbeiter, Roland M. Schmid

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature 554, 62-68 (2018)
Nature

The poor correlation of mutational landscapes with phenotypes limits our understanding of the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we show that oncogenic dosage-variation has a critical role in PDAC biology and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e231b6da1f1430a840ea2a8fe3e3f859
http://hdl.handle.net/10261/173621